Melanotan I
FDA APPROVED
Fda Approved
Skin
Melanotan I
7
Amino acids
Molecular weight
Peptide
Type
Synthetic analog of α-MSH that selectively targets MC1 receptors for melanin stimulation. FDA-approved as SCENESSE implant for erythropoietic protoporphyria (EPP). Research-grade injectable form enables flexible dosing versus the implant version.
Top researched benefits
Overview of Melanotan I
Subcutaneous injection delivers peptide directly into systemic circulation. Selectively activates MC1R receptors to stimulate melanin production. Short half-life of approximately 30 minutes necessitates multiple daily dosing for sustained effect.
Skin Health
- Stimulates melanin for deeper, longer-lasting tans with reduced UV requirements
- Increased melanin density provides natural UV protection and reduces sunburn
- Promotes uniform melanin distribution minimizing patchy tanning
Medical Applications
- FDA-approved indication for SCENESSE implant
Storage
Refrigerate reconstituted solution at 2-8°C, use within 4 weeks
Frequency
Loading phase: 1-2x daily for 1-2 weeks, then maintenance 2-3x weekly
Typical Dose
Loading: 0.25-0.5mg daily; Maintenance: 0.25-0.5mg 2-3x weekly
Cycle Duration
2-4 week loading phase, then ongoing maintenance as needed
Chemical Makeup
Key benefits
Precise dosing control with rapid tanning onset
Flexible home administration unlike implant version
Visible tanning within 1-2 weeks with UV exposure
Enhanced photoprotection through increased melanin
More selective for MC1R than Melanotan II
Community interest
This peptide is still gaining traction in the community.
Melanocortin Receptor Agonist
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesMelanotan I Molecular Information
View the scientifc details of Melanotan I.
7
Amino Acids
Melanotan I
?
?
Position 1
Asp
Asp
Position 2
His
His
Position 3
Phe
Phe
Position 4
Arg
Arg
Position 5
Trp
Trp
Position 6
Lys
Lys
Position 7
Molecular Weight
1024.2DaChain Length
7Amino AcidsType
PeptideMelanotan I Protocols
Subcutaneous injection with rotation between abdomen, thigh, and upper arm.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Loading phase | 0.25 | 1 week range | Subcutaneous |
| Maintenance | 0.25 | 2 week range | Subcutaneous |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clean vial top with alcohol pad
- Add 2mL bacteriostatic water for 5mg/mL concentration
- Gently swirl - do not shake
- Solution should be clear and colorless
- Store refrigerated for up to 4 weeks
Melanotan I Cycle
The Melanotan I Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- Possible mild nausea, facial flushing, reduced appetite
- Day 3-7
- Initial skin darkening, increased mole/freckle pigmentation
- Week 1-2
- Noticeable tanning with minimal UV exposure
- Week 2-4
- Peak effects, maintained pigmentation with reduced frequency
Dosing tools
Melanotan I Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
Melanotan I
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Melanotan I vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- Melanotan I
- Dosing
- Loading: 0.25-0.5mg daily; Maintenance: 0.25-0.5mg 2-3x weekly
- Dosing Frequency
- Loading phase: 1-2x daily for 1-2 weeks, then maintenance 2-3x weekly
- Cycle Duration
- 2-4 week loading phase, then ongoing maintenance as needed
- Storage
- Refrigerate reconstituted solution at 2-8°C, use within 4 weeks
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Melanotan I interactions with other common peptides and substances.
Side effects
Avoid: Do not take Melanotan I with Melanotan II.
Contraindications
Stop signs
Severe nausea/vomiting lasting >24 hours
Rapid concerning mole/freckle changes
Injection site infection signs
Unusual skin reactions
Allergic reaction symptoms
Bad signs
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Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
Melanotan IResearch References
Melanotan I is a fda approved compound
Melanotan I
Melanotan I is a fda approved compound
MT-I Photoprotection Study
Demonstrated significant photoprotection effects
n.d.
Melanocortin Receptor Binding Study
Characterized MC1R selectivity
n.d.
Pharmacokinetics Injectable MT-I
Established half-life and bioavailability parameters
n.d.