Semax

FDA APPROVAL PENDING

Well Studied

Cognitive

Longevity

Cognitive

Semax

Longevity

Amino acid sequence

7

Amino acids

813.9da

Molecular weight

Peptide

Type

Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10, originally developed in Russia for stroke recovery. It achieves enhanced CNS penetration through direct transport via olfactory epithelium and trigeminal nerves, bypassing the blood-brain barrier.

Top researched benefits

Overview of Semax

Rapidly increases BDNF levels, modulates dopaminergic and serotonergic systems, and achieves direct brain delivery through olfactory transport with 0.093% blood-brain barrier penetration (vs 0.01% IV).

Cognitive

  • Improved short-term and working memory performance in fatigued individuals (71% vs 41% accuracy).
  • Enhanced sustained attention during demanding cognitive tasks.
  • Faster acquisition of new information and improved retention.

Neuroprotection

  • Accelerated rehabilitation with increased BDNF levels in stroke patients.
  • Supports recovery from traumatic brain injury.
  • Shows anti-amyloid properties in Alzheimer's models.

Neuroplasticity

  • Supports neurogenesis through increased brain-derived neurotrophic factor.
  • Enhanced neural connections and brain network activity.
  • Improved ability to cope with cognitive stress.

Storage

Reconstituted: 2-8°C, use within recommended timeframe

Frequency

1-2x daily (morning recommended for cognitive boost)

Typical Dose

300-600mcg per dose (up to 1000mcg for intensive use)

Cycle Duration

2-4 weeks on

Chemical Makeup

Key benefits

Rapid brain delivery via intranasal route

Rapidly increases BDNF levels

Extensive clinical research in Russia

Easy self-administration

Modulates dopamine and serotonin systems

Neuroprotective effects

Community interest

This peptide is still gaining traction in the community.

Synthetic ACTH Analog | Nootropic & Neuroprotective Peptide

This overview is informational and based on aggregated descriptions from studies and user reports.

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Semax Molecular Information

View the scientifc details of Semax.

7

Amino Acids

Semax

Met

Met

Position 1

Glu

Glu

Position 2

His

His

Position 3

Phe

Phe

Position 4

Pro

Pro

Position 5

Gly

Gly

Position 6

Pro

Pro

Position 7

Amino acid sequence
MethioninePosition 1
Glutamic acidPosition 2
HistidinePosition 3
PhenylalaninePosition 4
ProlinePosition 5
GlycinePosition 6
ProlinePosition 7

Molecular Weight

813.9Da

Chain Length

7Amino Acids

Type

Peptide

Semax Protocols

Intranasal is the primary and most effective route, providing direct brain delivery through olfactory transport. Onset 15-30 minutes, peak 1-2 hours, duration 4-6 hours.

GoalDosageFrequencyRoute
Cognitive enhancement3001 week rangeIntranasal spray/drops
Intensive cognitive support6002 week rangeIntranasal
Brain injury recovery9002 week rangeIntranasal

Reconstitution Instructions

Materials needed:

Semax solution (0.1% or 1%)Nasal spray bottlePreservative-free saline (if reconstituting)

Steps to reconstitute

  1. Pre-mixed solutions available as 0.1% or 1%
  2. For research: reconstitute powder with sterile saline
  3. Use preservative-free saline for nasal administration
  4. Calculate concentration per spray/drop desired
  5. Refrigerate and use within recommended timeframe
  6. Alternate nostrils when administering

Semax Cycle

The Semax Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.

Taking breaks between cycles may help maintain effectiveness and support better overall results.

Day 1-3
Initial cognitive clarity and focus enhancement, possible mild nasal sensation
Week 0-0
Improved attention span during demanding tasks
Week 2-3
Enhanced memory consolidation, stable mood
Week 0-0
Peak cognitive benefits with improved stress resilience and mental flexibility
Week 0-0
Gradual baseline return over 3-7 days; some benefits persist

Dosing tools

Semax Peptide Dosage Calculator

Calculate peptide doses with our visual syringe guide.

0.3mL / 30 units

5 units

0.050 mL

1 mL

2 mL

3 mL

5 mL

Custom

Conversion: 1,000 mcg = 1 mg

Injection Results

Based on your vial and dilution inputs.

Safe concentration range

Semax

SINGLE COMPOUND

Volume per injection

0.05

mL

Concentration

10.00

mg/mL

Doses per vial

20

doses

Total injections per vial

20 injections

How it works

Based on a 10 mg Semax vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.

Research Purposes Only

These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.

Reference Guide

Dosing Cycle

Peptide
Semax
Dosing
300-600mcg per dose (up to 1000mcg for intensive use)
Dosing Frequency
1-2x daily (morning recommended for cognitive boost)
Cycle Duration
2-4 weeks on
Storage
Reconstituted: 2-8°C, use within recommended timeframe

Note: Triple agonist; microdose for fewer side effects

Reconstitution Tips

  • Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
  • Inject water slowly — aim down the vial wall, not directly onto powder
  • Never shake — gently swirl or roll the vial until dissolved
  • Store properly — refrigerate at 2-8°C after reconstitution
  • Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
  • Keep sterile — always clean vial tops with alcohol before drawing

Peptide Interactions

Research suggestions of Semax interactions with other common peptides and substances.

Healing

bpc

Longevity

BPC-157

COMPATIBLE

Both support neuroplasticity through different mechanisms.

COMPATIBLE

Cognitive

sel

Longevity

Selank

SYNERGISTIC

Complementary anxiolytic effects; popular combination.

SYNERGISTIC

Healing

tb5

Longevity

TB-500

COMPATIBLE

Comprehensive neuroprotection when combined.

COMPATIBLE

Side effects

Contraindications

Pregnancy or breastfeeding

Known peptide allergies

Do not exceed 4-week continuous use without medical supervision

Stop signs

Severe nasal irritation, bleeding, or persistent congestion

Unusual anxiety, agitation, or sleep disturbances

Headaches worsening with use

Signs of allergic reaction (rash, breathing difficulty)

Significant blood pressure changes or heart palpitations

Bad signs

Crystallization or precipitation indicates degradationCloudy or colored solutionsAny visible particles
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Frequently asked questions

What benefits can peptides offer in research?

Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.

What are some exciting applications of peptides in modern science?

Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.

How do peptides influence health and wellness?

Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.

Where can I find the latest studies on peptide applications?

Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.

Are there any guidelines for using peptides in research?

Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.

What is the difference between peptides and proteins?

Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.

How should peptides be stored?

Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.

Can peptides be taken orally?

Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.

SemaxResearch References

Semax is a well studied compound

4Research references

Semax

Semax is a well studied compound

Cognitive Enhancement in Fatigued Workers

Human study with 250-1000mcg intranasal single dose showed 71% accuracy on memory tests vs 41% in controls.

1996

Stroke Recovery Clinical Trial

110 patients with ischemic stroke showed increased BDNF levels correlated with early rehabilitation when using Semax with conventional therapy.

2018

fMRI Default Mode Network Study

24 healthy middle-aged participants showed increased fMRI default mode network activity relative to placebo.

2018

Neuroprotective Effects in Brain Ischemia

Rat focal ischemia model showed Semax affected expression of 96 genes related to immune and vascular systems.

2014