Longevity
NAD+
Metabolic
5
Amino acids
Molecular weight
Peptide
Type
NAD+ is a crucial coenzyme found in every cell, involved in energy generation and cellular maintenance that naturally declines with age. Supplementation may support cellular health, boost energy, enhance cognitive function, and promote longevity through multiple delivery methods.
Top researched benefits
Overview of NAD+
Direct delivery to bloodstream ensures maximum cellular availability for energy production via ATP synthesis, DNA repair through PARP activation, and sirtuin-mediated longevity pathways. Supports mitochondrial function and metabolic homeostasis.
energy and metabolism
- Restores NAD+ levels for optimal ATP synthesis
- Enhances glucose and fat metabolism
- Improves oxygen utilization and endurance
antiaging
- Activates PARP enzymes for genomic stability
- Supports longevity pathways
- May help clear senescent cells
neurological
- Improves mental clarity and focus
- Supports neuronal health and function
Typical Dose
IV: 250-1000mg; IM/SubQ: 100-500mg; Intranasal: 25-50mg; Oral precursors: 100-500mg NMN/NR
Frequency
IV: 1-2x weekly; IM/SubQ: 2-3x weekly; Intranasal: 1-2x daily; Oral: daily
Cycle Duration
4-12 weeks; IV therapy requires medical supervision
Storage
Refrigerate at 2-8°C; protect from light
Chemical Makeup
Key benefits
Restores mitochondrial function and ATP synthesis
Enhances glucose and fat metabolism
Improves oxygen utilization and endurance
Activates DNA repair mechanisms
Supports longevity pathways via sirtuins
Improves mental clarity and focus
Community interest
This peptide is still gaining traction in the community.
Essential Cellular Coenzyme & Anti-Aging Therapy
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoNAD+ Molecular Information
View the scientifc details of NAD+.
5
Amino Acids
NAD+
Cys
Cys
Position 1
His
His
Position 2
Asn
Asn
Position 3
Pyl
Pyl
Position 4
Pro
Pro
Position 5
Molecular Weight
663.43DaChain Length
5Amino AcidsType
PeptideNAD+ Protocols
Highest bioavailability (100%) via IV, IM, or subcutaneous injection.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| IV Infusion | 250 | 1 week range | Intravenous |
| IM/SubQ | 100 | 2 week range | Intramuscular or Subcutaneous |
NAD+ Cycle
The NAD+ Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Initial energy improvements and mental clarity
- Week 3-4
- Enhanced physical performance and recovery
- Week 5-8
- Sustained energy levels and improved sleep quality
- Week 9-12
- Optimized metabolic function and cognitive benefits
Dosing tools
NAD+ Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
NAD+
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg NAD+ vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- NAD+
- Dosing
- IV: 250-1000mg; IM/SubQ: 100-500mg; Intranasal: 25-50mg; Oral precursors: 100-500mg NMN/NR
- Dosing Frequency
- IV: 1-2x weekly; IM/SubQ: 2-3x weekly; Intranasal: 1-2x daily; Oral: daily
- Cycle Duration
- 4-12 weeks; IV therapy requires medical supervision
- Storage
- Refrigerate at 2-8°C; protect from light
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of NAD+ interactions with other common peptides and substances.
Weight
ipa
Growth
Ipamorelin
SYNERGISTIC
Growth hormone pathways benefit from improved energy metabolism
Side effects
Contraindications
IV administration requires medical supervision
Avoid alcohol during treatment
Maintain consistent dosing schedule
Stop signs
Severe injection site reactions or infection signs
Persistent nausea or gastrointestinal distress
Unusual fatigue or weakness
Allergic reactions (rash, swelling, breathing difficulty)
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
NAD+Research References
NAD+ is an extensively studied compound
NAD+
NAD+ is an extensively studied compound
NAD+ Restoration Strategies in Clinical Practice
Review of clinical applications and restoration strategies
n.d.
Clinical Evidence for NAD+ Therapeutic Applications
Evidence for anti-aging and therapeutic applications
n.d.
NAD+ Precursor Safety and Efficacy Meta-Analysis
Meta-analysis of safety and efficacy data
n.d.
Intranasal NAD+ Delivery for Neurological Applications
Demonstrated efficacy of intranasal delivery for brain access
n.d.