Longevity Peptide Cheat Sheet

Selank is a synthetic heptapeptide derived from tuftsin with anxiolytic, nootropic, and immunomodulatory properties; it is most commonly administered as a nasal spray and is noted for reducing anxiety while enhancing focus and memory without sedation or dependence.

P21 is a synthetic peptide derived from CNTF (Ciliary Neurotrophic Factor) that promotes neurogenesis, BDNF expression, and cognitive function without the side effects associated with full-length CNTF. It is commonly used intranasally or via subcutaneous injection for memory enhancement and neuroprotection.

Thymulin is a thymic nonapeptide hormone that promotes T-cell differentiation and immune regulation, with research suggesting anti-inflammatory and anti-aging properties. It requires zinc as a cofactor for biological activity and is studied for immune restoration, particularly in age-related immune decline.

Pre-made solution at ~215 mg/mL (~1 g total); no reconstitution needed. Administer IM or slow IV. Cerebrolysin is a porcine brain-derived peptide mixture with neurotrophic and neuroprotective properties, clinically used for stroke, dementia, and TBI recovery. Biohackers use it for cognitive enhancement, neuroplasticity, and neuroprotection.

Crystagen is a short peptide bioregulator (tripeptide) derived from the cerebellum, primarily used to support brain and nervous system function, cognitive performance, and neuroprotection. It is commonly cycled in the Khavinson bioregulator protocol and may support neuronal health and age-related cognitive decline.

Cortagen is a short-chain peptide (Ala-Glu-Asp-Pro) developed by the St. Petersburg Institute of Bioregulation and Gerontology, designed to support brain and nervous system function by promoting neuronal protein synthesis and cognitive health. It is typically used in short courses to support memory, focus, and neuroprotection, and is part of the Khavinson peptide bioregulator class.

Blend of Selank, Semax, Pinealon, and PE-22-28 targeting mood, memory, focus, and neurogenesis. Nasal spray formulations need no BAC water; injectable versions use 1–2 mL. Frequency: daily or 5 on/2 off. Dose is product-dependent.

NA Semax Amidate is a modified, more potent and stable form of Semax featuring an N-acetyl group and C-terminal amidation, which increase bioavailability and resistance to enzymatic degradation. It is used primarily for cognitive enhancement, neuroprotection, BDNF upregulation, focus, and anxiety reduction, and is commonly administered subcutaneously or intranasally.

Ovagen is a peptide bioregulator (cytomax) derived from liver and pancreas tissue, developed by the Khavinson Institute in Russia, primarily used to support liver function, hepatocyte regeneration, and digestive health. It is often cycled 2–3 times per year and is noted for its ability to normalize liver enzyme activity and support gut tissue repair.

Pinealon is a tripeptide (Glu-Asp-Arg) derived from pineal gland tissue, studied for its neuroprotective and cognitive-enhancing effects. It is reported to improve memory, reduce oxidative stress in brain tissue, and support circadian rhythm regulation, often used in short cyclical courses.

Thymogen (Glu-Trp) is a synthetic dipeptide derived from the thymus gland that modulates immune function by stimulating T-cell maturation and enhancing cellular immunity. It is used to support immune restoration, particularly in immunodeficient states, and has been researched for its anti-aging and immunomodulatory properties.

Nasal spray; 0.1% or 1% solution — 2–3 drops per nostril per dose. Frequency: daily or 5 on/2 off. Semax is a synthetic heptapeptide derived from ACTH that increases BDNF and NGF expression, supporting memory, focus, and neuroprotection. Widely used in Russia as a prescription nootropic.

Experimental senolytic; rare and costly

Testagen (Lys-Glu-Asp-Gly) is a short tetrapeptide bioregulator developed by the Khavinson Institute in Russia, originally derived from the testes, believed to support testicular function, hormonal balance, and male reproductive health. It is used in peptide bioregulator protocols for restoring organ-specific function and is often cycled alongside other bioregulators as part of longevity and anti-aging regimens.

NA-Selank Amidate is a synthetic analog of the endogenous tetrapeptide tuftsin, modified with an N-acetyl group and amidated C-terminus to enhance stability and bioavailability; it is primarily used for anxiolytic effects, cognitive enhancement, and mood stabilization without sedation or dependence. It modulates the GABAergic and serotonergic systems and is popular among biohackers for reducing anxiety while improving focus and mental clarity.

PNC-27 is a synthetic peptide derived from the p53 tumor suppressor protein that selectively induces necrosis in cancer cells by inserting into their membranes, which over-express HDM-2, while leaving normal cells unharmed. It remains largely experimental with use confined to research settings; human dosing protocols are not well established.

Thymosin Beta-4 (TB-500) is a naturally occurring peptide that promotes tissue repair, reduces inflammation, and accelerates healing of muscles, tendons, ligaments, and skin. It works by upregulating actin and promoting cell migration and angiogenesis, making it popular for injury recovery and wound healing.

PE-22-28 is a synthetic truncated analog of spadin, a peptide derived from the TREK-1 potassium channel antagonist, studied for its rapid antidepressant and neuroprotective effects. It is believed to work by blocking TREK-1 channels, promoting serotonin signaling and neurogenesis, making it of interest for depression, anxiety, and cognitive support.

Dihexa is a potent nootropic peptide derived from angiotensin IV that promotes synaptogenesis and enhances cognitive function, particularly memory and learning. It is typically administered orally or transdermally and is reported to be significantly more potent than BDNF at promoting new neural connections.

Livagen is a short tetrapeptide (Lys-Glu-Asp-Ala) developed by the St. Petersburg Institute of Bioregulation, primarily studied for its ability to activate chromatin and restore gene expression in immune and cardiac cells, supporting longevity and cardiovascular health. It is used in peptide bioregulator protocols alongside other Khavinson peptides to support immune function and slow age-related cellular decline.

Vesilute is a short-chain peptide bioregulator (cytomax class) developed to support bladder tissue function and urological health, promoting cellular regeneration in the urinary bladder epithelium. It is typically used in short course protocols similar to other Russian peptide bioregulators and may support recovery from urological conditions.

Metabolic regulator, mimics exercise

Mitochondrial support

Accelerates tissue healing

Joint health, repair and regeneration

Telomerase activator, used in cycles

Enhances skin regeneration

Detox, inflammation, skin

Cell energy coenzyme

Restores immune balance (subQ)

Supports vascular health

Mild immunomodulator (subQ)

Blend of BPC-157 (5 mg) and TB-500 (5 mg) for accelerated tissue recovery. Can be used daily or 2×/week depending on injury severity.

Regenerates tissue, reduces inflammation

The BPC-157 of immunity. Great for immune system

Cell protective mitochondrial peptide

Skin and repair blend. Dose is based on GHK-Cu content in the specific blend formulation.

Skin and repair blend. Dose is based on GHK-Cu content in the specific blend formulation.

Mitochondrial function; fat loss support

Reduces fat, increases endurance

Fragment variant of TB-500; regenerates tissue, reduces inflammation

Blend of BPC-157, KPV, and TB-500 for gut and systemic tissue repair. Can be used daily or 2×/week.