PT-141
FDA APPROVED
Fda Approved
Sexual
PT-141
7
Amino acids
Molecular weight
Peptide
Type
FDA-approved melanocortin receptor agonist for treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. Works centrally in the nervous system to trigger sexual arousal pathways independent of vascular mechanisms, unlike traditional ED medications.
Top researched benefits
Overview of PT-141
Selectively activates melanocortin receptors (MC3R/MC4R) in the central nervous system, triggering sexual arousal pathways independent of peripheral vascular mechanisms. Works within 45 minutes with effects lasting 6-12 hours.
Sexual Health
- FDA-approved for treatment of HSDD in premenopausal women.
- Effective in men including PDE5 inhibitor-resistant cases via CNS pathways.
- Enhances sexual arousal and desire in women.
Quality Of Life
- Reduces distress related to low sexual desire.
- Enhanced satisfaction reported in clinical trials.
Storage
Refrigerate at 2-8°C, use reconstituted solution within 30 days
Frequency
As needed before sexual activity; max 1 dose per 24 hours
Typical Dose
Women: 1.75mg (FDA-approved); Men: 1-2mg; Start 0.5mg test dose for tolerance
Cycle Duration
Use as needed for sexual enhancement
Chemical Makeup
Key benefits
FDA-approved pharmaceutical route
Predictable absorption profile
Effective for both male and female sexual dysfunction
Works within 45 minutes
Effective in PDE5 inhibitor-resistant cases
Central mechanism (not dependent on blood flow)
Community interest
This peptide is still gaining traction in the community.
Melanocortin Receptor Agonist | Sexual Dysfunction Treatment
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesPT-141 Molecular Information
View the scientifc details of PT-141.
7
Amino Acids
PT-141
?
?
Position 1
Asp
Asp
Position 2
His
His
Position 3
Phe
Phe
Position 4
Arg
Arg
Position 5
Trp
Trp
Position 6
Lys
Lys
Position 7
Molecular Weight
1025.2DaChain Length
7Amino AcidsType
PeptidePT-141 Protocols
Subcutaneous injection is the FDA-approved route. Administered 45-60 minutes before anticipated sexual activity.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Female HSDD (FDA-approved) | 1.75 | 1 week range | SubQ |
| Male Erectile Dysfunction | 1 | 45 week range | SubQ |
| Female Arousal Disorder | 0.75 | 1 week range | SubQ |
| Low Starting Dose | 0.5 | — | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Allow vial to reach room temperature (15-20 minutes)
- Clean vial tops with alcohol swabs
- Draw 1-2mL bacteriostatic water
- Inject BAC water slowly down vial side
- Gently swirl until fully dissolved (do not shake)
- Solution should appear clear and colorless
- Store reconstituted solution refrigerated
- Use within 30 days of reconstitution
PT-141 Cycle
The PT-141 Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Mild nausea or facial flushing possible
- Week 0-0
- Onset of effects - increased arousal and desire
- Week 0-0
- Peak effects - enhanced sexual response
- Week 0-0
- Gradual diminishment of effects
Dosing tools
PT-141 Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
PT-141
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg PT-141 vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- PT-141
- Dosing
- Women: 1.75mg (FDA-approved); Men: 1-2mg; Start 0.5mg test dose for tolerance
- Dosing Frequency
- As needed before sexual activity; max 1 dose per 24 hours
- Cycle Duration
- Use as needed for sexual enhancement
- Storage
- Refrigerate at 2-8°C, use reconstituted solution within 30 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of PT-141 interactions with other common peptides and substances.
Side effects
Monitor: Be careful when combining PT-141 with Kisspeptin, Melanotan II.
Contraindications
Uncontrolled hypertension
Cardiovascular disease
Use of nitrate medications
Pregnancy or breastfeeding
Stop signs
Severe or persistent nausea/vomiting
Significant blood pressure drop or dizziness
Chest pain or irregular heartbeat
Severe headache or vision changes
Prolonged erection exceeding 4 hours
Bad signs
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Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.
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Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.
How should peptides be stored?
Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.
Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
PT-141Research References
PT-141 is a fda approved compound
PT-141
PT-141 is a fda approved compound
FDA Approval Trial for HSDD
Phase 3 trials with 1.75mg subcutaneous in premenopausal women showed 24.5% improvement vs 17.2% placebo, achieving statistical significance.
2019
Male Erectile Dysfunction Clinical Trial
1-20mg intranasal showed dose-dependent erectile response, effective including in PDE5 inhibitor-resistant cases via CNS pathways.
2017
Mechanism of Action Study
In vitro and animal studies confirmed selective MC3R/MC4R binding activating sexual arousal without peripheral vasodilation.
2016