PT-141
FDA APPROVED
Fda Approved
Sexual
PT-141
7
Amino acids
Molecular weight
Peptide
Type
FDA-approved melanocortin receptor agonist for treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. Works centrally in the nervous system to trigger sexual arousal pathways independent of vascular mechanisms, unlike traditional ED medications.
Top researched benefits
Overview of PT-141
Selectively activates melanocortin receptors (MC3R/MC4R) in the central nervous system, triggering sexual arousal pathways independent of peripheral vascular mechanisms. Works within 45 minutes with effects lasting 6-12 hours.
sexual health
- FDA-approved for treatment of HSDD in premenopausal women.
- Effective in men including PDE5 inhibitor-resistant cases via CNS pathways.
- Enhances sexual arousal and desire in women.
quality of life
- Reduces distress related to low sexual desire.
- Enhanced satisfaction reported in clinical trials.
Typical Dose
Women: 1.75mg (FDA-approved); Men: 1-2mg; Start 0.5mg test dose for tolerance
Frequency
As needed before sexual activity; max 1 dose per 24 hours
Cycle Duration
Use as needed for sexual enhancement
Storage
Refrigerate at 2-8°C, use reconstituted solution within 30 days
Chemical Makeup
Key benefits
FDA-approved pharmaceutical route
Predictable absorption profile
Effective for both male and female sexual dysfunction
Works within 45 minutes
Effective in PDE5 inhibitor-resistant cases
Central mechanism (not dependent on blood flow)
Community interest
This peptide is still gaining traction in the community.
Melanocortin Receptor Agonist | Sexual Dysfunction Treatment
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoPT-141 Molecular Information
View the scientifc details of PT-141.
7
Amino Acids
PT-141
?
?
Position 1
Asp
Asp
Position 2
His
His
Position 3
Phe
Phe
Position 4
Arg
Arg
Position 5
Trp
Trp
Position 6
Lys
Lys
Position 7
Molecular Weight
1025.2DaChain Length
7Amino AcidsType
PeptidePT-141 Protocols
Subcutaneous injection is the FDA-approved route. Administered 45-60 minutes before anticipated sexual activity.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Female HSDD (FDA-approved) | 1.75 | 1 week range | SubQ |
| Male Erectile Dysfunction | 1 | 45 week range | SubQ |
| Female Arousal Disorder | 0.75 | 1 week range | SubQ |
| Low Starting Dose | 0.5 | — | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Allow vial to reach room temperature (15-20 minutes)
- Clean vial tops with alcohol swabs
- Draw 1-2mL bacteriostatic water
- Inject BAC water slowly down vial side
- Gently swirl until fully dissolved (do not shake)
- Solution should appear clear and colorless
- Store reconstituted solution refrigerated
- Use within 30 days of reconstitution
PT-141 Cycle
The PT-141 Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Mild nausea or facial flushing possible
- Week 0-0
- Onset of effects - increased arousal and desire
- Week 0-0
- Peak effects - enhanced sexual response
- Week 0-0
- Gradual diminishment of effects
Dosing tools
PT-141 Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
PT-141
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg PT-141 vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- PT-141
- Dosing
- Women: 1.75mg (FDA-approved); Men: 1-2mg; Start 0.5mg test dose for tolerance
- Dosing Frequency
- As needed before sexual activity; max 1 dose per 24 hours
- Cycle Duration
- Use as needed for sexual enhancement
- Storage
- Refrigerate at 2-8°C, use reconstituted solution within 30 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of PT-141 interactions with other common peptides and substances.
Side effects
Monitor: Be careful when combining PT-141 with Kisspeptin, Melanotan II.
Contraindications
Uncontrolled hypertension
Cardiovascular disease
Use of nitrate medications
Pregnancy or breastfeeding
Stop signs
Severe or persistent nausea/vomiting
Significant blood pressure drop or dizziness
Chest pain or irregular heartbeat
Severe headache or vision changes
Prolonged erection exceeding 4 hours
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
PT-141Research References
PT-141 is a fda approved compound
PT-141
PT-141 is a fda approved compound
FDA Approval Trial for HSDD
Phase 3 trials with 1.75mg subcutaneous in premenopausal women showed 24.5% improvement vs 17.2% placebo, achieving statistical significance.
2019
Male Erectile Dysfunction Clinical Trial
1-20mg intranasal showed dose-dependent erectile response, effective including in PDE5 inhibitor-resistant cases via CNS pathways.
2017
Mechanism of Action Study
In vitro and animal studies confirmed selective MC3R/MC4R binding activating sexual arousal without peripheral vasodilation.
2016