Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
FDA APPROVAL PENDING
Experimental
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Nootropic Peptide Blend | Cognitive & Mood Enhancement
Learn moreCognitive
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
25
Amino acids
Molecular weight
Blend
Type
Illumineuro is a four-peptide nootropic blend combining N-Acetyl Semax Amidate (MW 813.93 Da), N-Acetyl Selank Amidate (MW 751.89 Da), Pinealon/EDR tripeptide (MW 418.41 Da), and PE-22-28/Mini-Spadin (MW 773.88 Da), formulated to target overlapping neural pathways governing cognition, mood, and neuroplasticity. Two components — Semax and Selank — are registered pharmaceutical medicines in Russia with substantial clinical use data: Semax has been on Russia's List of Vital and Essential Drugs since 2011 and is prescribed for stroke recovery and cognitive decline, while Selank received Russian regulatory approval in 2009 for generalized anxiety disorder. No clinical trials exist on this specific four-compound combination, which remains experimental as a blend.
Top researched benefits
PE-22-28 Neuritogenic Effects
PE-22-28 promotes neurite outgrowth through S1P receptor modulation.
NA-Semax Amidate Cognitive Enhancement
Enhanced stability amidate form of Semax with BDNF upregulation and neuroprotective effects.
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Body Targets
The areas of the body that Selank, Semax, Pinealon, PE-22-28 (Illumineuro) primarily affects.
2
Body Targets
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Brain
Research targets include neurological signaling, memory pathways, and neuroprotective mechanisms.
Sleep
Research targets include circadian signaling pathways and sleep-wake cycle regulation.
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Targeted areas
Overview of Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Each component operates through a distinct mechanism: NA-Semax Amidate upregulates BDNF and NGF mRNA in the hippocampus and prefrontal cortex via ACTH(4-10) receptor binding; NA-Selank Amidate modulates GABA-A receptor subunits and inhibits enkephalin degradation to produce anxiolytic effects; Pinealon (Glu-Asp-Arg tripeptide) acts as an epigenetic bioregulator, binding directly to DNA promoter regions of neuroprotective genes such as S100B; PE-22-28 (Mini-Spadin) selectively inhibits TREK-1 background potassium channels (IC50 0.12 nM), depolarizing serotonergic neurons in the dorsal raphe nucleus to enhance serotonergic transmission and hippocampal neurogenesis.
cognitive enhancement
- Combined BDNF support and neuritogenic effects may enhance memory formation and learning.
- NA-Semax component supports sustained attention and mental clarity.
- Multiple pathways protecting neural tissue from oxidative stress and damage.
mood and anxiety
- NA-Selank provides anxiolytic effects through GABA modulation.
- Immune-neuroendocrine support helps with stress resilience.
- Combined effects on neurotransmitter systems may improve overall mood.
neural health
- PE-22-28 promotes neural connectivity and neurite extension.
- Pinealon supports healthy sleep-wake cycles and pineal function.
Research Dose (Reference)
300mcg per dose (midpoint of 200–400mcg range)
Research Frequency (Reference)
once daily
Research Cycle (Reference)
8 weeks on, 4 weeks off
Storage
Lyophilized: store at -20°C long-term or room temperature short-term. Reconstituted: refrigerate at 2–8°C, use within 28 days. Do not freeze reconstituted solution.
Chemical Makeup
Key benefits
Upregulates BDNF and NGF expression in hippocampus and prefrontal cortex (Semax component), supporting neuroplasticity and memory consolidation
Reduces anxiety via GABA-A receptor modulation and enkephalin preservation (Selank component) without sedation or dependence risk associated with benzodiazepines
Inhibits TREK-1 potassium channels (PE-22-28 component), activating serotonergic pathways and inducing hippocampal neurogenesis after as few as 4 days of treatment in preclinical models
Pinealon tripeptide directly binds neuroprotective gene promoters (including S100B) to regulate epigenetic expression in neural tissue, supporting neuroprotection and circadian function
Community interest
This peptide is still gaining traction in the community.
Nootropic Peptide Blend | Cognitive & Mood Enhancement
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoSelank, Semax, Pinealon, PE-22-28 (Illumineuro) Molecular Information
View the scientifc details of Selank, Semax, Pinealon, PE-22-28 (Illumineuro).
25
Amino Acids
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Pro
Pro
Position 1
Glu
Glu
Position 2
Pro
Pro
Position 3
Ile
Ile
Position 4
Asn
Asn
Position 5
Glu
Glu
Position 6
Ala
Ala
Position 7
Leu
Leu
Position 8
Pyl
Pyl
Position 9
Asn
Asn
Position 10
Asn
Asn
Position 11
Ala
Ala
Position 12
Ser
Ser
Position 13
Glu
Glu
Position 14
Met
Met
Position 15
Ala
Ala
Position 16
?
?
Position 17
Asn
Asn
Position 18
Ala
Ala
Position 19
Ser
Ser
Position 20
Glu
Glu
Position 21
Leu
Leu
Position 22
Ala
Ala
Position 23
Asn
Asn
Position 24
Lys
Lys
Position 25
Molecular Weight
689.53DaChain Length
25Amino AcidsType
BlendSelank, Semax, Pinealon, PE-22-28 (Illumineuro) Protocols
Subcutaneous injection is a secondary administration option for the Illumineuro blend. Individual components — particularly Semax and Selank — have documented SubQ research precedent, and some compounding providers supply the blend in injectable form; however, combined SubQ administration of this specific four-component formulation is less characterized than intranasal use and should be considered with that caveat in mind. Morning dosing on an empty stomach in the abdomen or thigh is the most commonly referenced approach when this route is chosen.
100 mcg
Beginner / conservative support
Assess individual tolerance to the blended components via the injectable route before advancing to higher doses
SubQ (abdomen or thigh)
1 day range
300 mcg
Standard cognitive enhancement
Improve daily focus, information processing speed, and working memory through consistent morning SubQ administration
SubQ (abdomen or thigh)
1 day range
250 mcg
Anxiety and stress modulation
Reduce anxiety and stress reactivity across the day using split dosing to maintain stable plasma levels of the Selank component
SubQ (abdomen or thigh)
2 day range
500 mcg
Enhanced nootropic / mood support
Support elevated mood, motivation, and neuroplasticity over a 4–8 week cycle via combined BDNF and GABAergic pathway engagement
SubQ (abdomen or thigh)
1 day range
400 mcg
Neuroprotection and neuroplasticity
Protect neurons from oxidative stress and support long-term structural brain health, drawing on Pinealon's membrane-penetrating neuroprotective properties
SubQ (abdomen or thigh)
1 day range
500 mcg
Immunomodulation and inflammation support
Harness the Semax and Selank components' immune-modulatory effects to reduce neuroinflammatory burden during periods of elevated physiological stress
SubQ (abdomen or thigh)
1 day range
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Reconstitution Guide
Learn how to reconstitute Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Materials needed
Illumineuro lyophilized powder vial (48–50 mg total blend)
Bacteriostatic water (BAC water), 2 mL per vial
Insulin syringes (0.5–1 mL, 29–31 gauge, 6–8 mm needle)
Sterile draw-up syringe (3 mL) for reconstitution
Alcohol swabs
Allow the Illumineuro lyophilized powder vial to warm to room temperature for 15 minutes before reconstitution
Wipe the rubber stopper of the vial with a fresh alcohol swab and let it dry fully
Draw 2 mL of bacteriostatic water into a sterile 3 mL syringe
Insert the needle into the vial at an angle and inject the BAC water slowly down the inner wall — do not spray it directly onto the lyophilized powder
Remove the syringe and gently swirl the vial in slow circular motions until fully dissolved — do not shake or vortex
Inspect the solution: it must be clear and colorless with no visible particles; discard if cloudy or particulate
Label the vial with the reconstitution date; store at 2–8°C and use within 28 days
Wipe the vial stopper with a fresh alcohol swab before each draw; use an insulin syringe to draw the target volume
Pinch a small fold of skin at the injection site (abdomen or thigh), insert the needle at a 45–90 degree angle, and inject slowly over 5–10 seconds
Apply gentle pressure with a clean swab after withdrawing the needle; do not rub the site
Rotate injection sites with each dose to prevent localized irritation
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Cycle
The Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Cycle section explains how long a typical cycle lasts and what research data suggests about each phase. In research contexts, biological systems may show reduced responsiveness with continuous exposure.
Research protocols often include washout periods between cycles to study baseline recovery and maintain experimental validity.
- Day 1-3
- NA-Semax/Selank effects may be noticeable quickly (focus, anxiety reduction)
- Week 1-2
- Cognitive enhancement and mood effects develop
- Week 2-4
- Neuritogenic and BDNF effects building
- Week 4-8
- Full protocol benefits; assess and cycle off
Dosing tools
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)Blend Dosage Calculator
Calculate blended peptide doses with our visual syringe guide.
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
1 mL
2 mL
3 mL
5 mL
Custom
Blend Composition
Total: 20.0 mg
mg
mg
The compound you want to dose by. Results will be calculated based on this compound.
The target research quantity of the anchor compound per administration, in mcg or mg.
Conversion: 1,000 mcg = 1 mg
Results
Concentration
20.00
mg/mL
Doses per vial
40
Total blend volume
0.50
mg
You'll get:
- PE-22-28
- 250 mcgANCHOR
- Pinealon
- 250 mcg
1mL / 100 units
2 units
0.025 mL
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Dosing Guidance
Recommended Schedule
once daily
Supply Duration
This vial provides 40 doses (40-day supply at 250 mcg daily)
Peptide Interactions
Research suggestions of Selank, Semax, Pinealon, PE-22-28 (Illumineuro) interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Different targets; BPC-157 may complement with healing/gut-brain effects.
Cognitive
dih
Longevity
Dihexa
MONITOR
Both highly neuroactive; use caution combining multiple cognitive enhancers.
Longevity
epi
Immunity
Epitalon
COMPATIBLE
Complementary pineal/longevity support; different mechanisms.
Side effects
Monitor in research: Exercise caution when studying Selank, Semax, Pinealon, PE-22-28 (Illumineuro) with Dihexa.
Contraindications
No clinical trials on four-peptide combination
Bipolar disorder or psychosis (caution with cognitive enhancers)
Pregnancy or breastfeeding
Seizure disorders (theoretical concern)
Stop signs
Severe headaches
Significant mood changes
Allergic reactions
Cognitive impairment instead of enhancement
Bad signs
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)Research References
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) is an experimental compound
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) is an experimental compound
PE-22-28 Neuritogenic Effects
PE-22-28 promotes neurite outgrowth through S1P receptor modulation.
n.d.
NA-Semax Amidate Cognitive Enhancement
Enhanced stability amidate form of Semax with BDNF upregulation and neuroprotective effects.
n.d.
NA-Selank Amidate Anxiolytic Properties
Selank demonstrates anxiolytic effects through GABA modulation and immune-neuroendocrine regulation.
n.d.
Pinealon Bioregulator
Pinealon (EDR tripeptide) supports pineal gland function and circadian regulation.
n.d.
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Frequently asked questions
What is a peptide protocol?
A peptide protocol is a structured research plan that specifies which peptides to study, the quantities and frequencies used in research settings, and the duration of the study period. Research protocols often combine multiple peptides that act on complementary biological pathways—such as tissue repair, cognitive function, or metabolic regulation—to investigate broader or synergistic effects. These protocols are intended for research purposes only and are not a guide for human consumption.
How is peptide dosage calculated from a vial for research?
In a research context, the concentration of a reconstituted peptide solution is calculated by dividing the total peptide content of the vial in micrograms by the volume of bacteriostatic water added in milliliters. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water yields a concentration of 2,500 mcg/mL. This information is provided for reference and laboratory calculation purposes only — not as a guide for human use.
How much bacteriostatic water is typically used for peptide reconstitution in research?
Research protocols commonly reconstitute peptide vials with 2mL to 3mL of bacteriostatic water, though the appropriate volume depends on the target concentration needed for a given study. Adding 2mL to a 5mg vial yields a concentration of 2,500 mcg/mL. This information is provided strictly for laboratory and research reference — not as instructions for human use.
How are peptides different from proteins?
Both are composed of amino acids, but peptides are significantly smaller than proteins. Due to their size, peptides can function as precise signaling molecules, binding to specific receptors and triggering targeted biological responses—such as stimulating growth hormone release, promoting tissue repair, or modulating immune activity. These mechanisms are the subject of ongoing scientific research.
Calculate peptide research quantities
Reference our peptide dosage, blend, and accumulation calculators for research purposes. Enter vial size, reconstitution volume, and target research quantity to calculate draw volumes instantly. For research use only — not administration or dosing guidance of any kind.
