Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
FDA APPROVAL PENDING
Experimental
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Nootropic Peptide Blend | Cognitive & Mood Enhancement
Learn moreCognitive
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
25
Amino acids
Molecular weight
Blend
Type
Illumineuro is a four-peptide nootropic blend combining N-Acetyl Semax Amidate (MW 813.93 Da), N-Acetyl Selank Amidate (MW 751.89 Da), Pinealon/EDR tripeptide (MW 418.41 Da), and PE-22-28/Mini-Spadin (MW 773.88 Da), formulated to target overlapping neural pathways governing cognition, mood, and neuroplasticity. Two components — Semax and Selank — are registered pharmaceutical medicines in Russia with substantial clinical use data: Semax has been on Russia's List of Vital and Essential Drugs since 2011 and is prescribed for stroke recovery and cognitive decline, while Selank received Russian regulatory approval in 2009 for generalized anxiety disorder. No clinical trials exist on this specific four-compound combination, which remains experimental as a blend.
Top researched benefits
Overview of Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Each component operates through a distinct mechanism: NA-Semax Amidate upregulates BDNF and NGF mRNA in the hippocampus and prefrontal cortex via ACTH(4-10) receptor binding; NA-Selank Amidate modulates GABA-A receptor subunits and inhibits enkephalin degradation to produce anxiolytic effects; Pinealon (Glu-Asp-Arg tripeptide) acts as an epigenetic bioregulator, binding directly to DNA promoter regions of neuroprotective genes such as S100B; PE-22-28 (Mini-Spadin) selectively inhibits TREK-1 background potassium channels (IC50 0.12 nM), depolarizing serotonergic neurons in the dorsal raphe nucleus to enhance serotonergic transmission and hippocampal neurogenesis.
cognitive enhancement
- Combined BDNF support and neuritogenic effects may enhance memory formation and learning.
- NA-Semax component supports sustained attention and mental clarity.
- Multiple pathways protecting neural tissue from oxidative stress and damage.
mood and anxiety
- NA-Selank provides anxiolytic effects through GABA modulation.
- Immune-neuroendocrine support helps with stress resilience.
- Combined effects on neurotransmitter systems may improve overall mood.
neural health
- PE-22-28 promotes neural connectivity and neurite extension.
- Pinealon supports healthy sleep-wake cycles and pineal function.
Typical Dose
300mcg per dose (midpoint of 200–400mcg range)
Frequency
once daily
Cycle Duration
8 weeks on, 4 weeks off
Storage
Lyophilized: store at -20°C long-term or room temperature short-term. Reconstituted: refrigerate at 2–8°C, use within 28 days. Do not freeze reconstituted solution.
Chemical Makeup
Key benefits
Upregulates BDNF and NGF expression in hippocampus and prefrontal cortex (Semax component), supporting neuroplasticity and memory consolidation
Reduces anxiety via GABA-A receptor modulation and enkephalin preservation (Selank component) without sedation or dependence risk associated with benzodiazepines
Inhibits TREK-1 potassium channels (PE-22-28 component), activating serotonergic pathways and inducing hippocampal neurogenesis after as few as 4 days of treatment in preclinical models
Pinealon tripeptide directly binds neuroprotective gene promoters (including S100B) to regulate epigenetic expression in neural tissue, supporting neuroprotection and circadian function
Community interest
This peptide is still gaining traction in the community.
Nootropic Peptide Blend | Cognitive & Mood Enhancement
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoSelank, Semax, Pinealon, PE-22-28 (Illumineuro) Molecular Information
View the scientifc details of Selank, Semax, Pinealon, PE-22-28 (Illumineuro).
25
Amino Acids
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Pro
Pro
Position 1
Glu
Glu
Position 2
Pro
Pro
Position 3
Ile
Ile
Position 4
Asn
Asn
Position 5
Glu
Glu
Position 6
Ala
Ala
Position 7
Leu
Leu
Position 8
Pyl
Pyl
Position 9
Asn
Asn
Position 10
Asn
Asn
Position 11
Ala
Ala
Position 12
Ser
Ser
Position 13
Glu
Glu
Position 14
Met
Met
Position 15
Ala
Ala
Position 16
?
?
Position 17
Asn
Asn
Position 18
Ala
Ala
Position 19
Ser
Ser
Position 20
Glu
Glu
Position 21
Leu
Leu
Position 22
Ala
Ala
Position 23
Asn
Asn
Position 24
Lys
Lys
Position 25
Molecular Weight
689.53DaChain Length
25Amino AcidsType
BlendSelank, Semax, Pinealon, PE-22-28 (Illumineuro) Protocols
Subcutaneous injection is a secondary administration option for the Illumineuro blend. Individual components — particularly Semax and Selank — have documented SubQ research precedent, and some compounding providers supply the blend in injectable form; however, combined SubQ administration of this specific four-component formulation is less characterized than intranasal use and should be considered with that caveat in mind. Morning dosing on an empty stomach in the abdomen or thigh is the most commonly referenced approach when this route is chosen.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Assess individual tolerance to the blended components via the injectable route before advancing to higher doses | 100 | 1 day range | SubQ (abdomen or thigh) |
| Improve daily focus, information processing speed, and working memory through consistent morning SubQ administration | 300 | 1 day range | SubQ (abdomen or thigh) |
| Reduce anxiety and stress reactivity across the day using split dosing to maintain stable plasma levels of the Selank component | 250 | 2 day range | SubQ (abdomen or thigh) |
| Support elevated mood, motivation, and neuroplasticity over a 4–8 week cycle via combined BDNF and GABAergic pathway engagement | 500 | 1 day range | SubQ (abdomen or thigh) |
| Protect neurons from oxidative stress and support long-term structural brain health, drawing on Pinealon's membrane-penetrating neuroprotective properties | 400 | 1 day range | SubQ (abdomen or thigh) |
| Harness the Semax and Selank components' immune-modulatory effects to reduce neuroinflammatory burden during periods of elevated physiological stress | 500 | 1 day range | SubQ (abdomen or thigh) |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Allow the Illumineuro lyophilized powder vial to warm to room temperature for 15 minutes before reconstitution
- Wipe the rubber stopper of the vial with a fresh alcohol swab and let it dry fully
- Draw 2 mL of bacteriostatic water into a sterile 3 mL syringe
- Insert the needle into the vial at an angle and inject the BAC water slowly down the inner wall — do not spray it directly onto the lyophilized powder
- Remove the syringe and gently swirl the vial in slow circular motions until fully dissolved — do not shake or vortex
- Inspect the solution: it must be clear and colorless with no visible particles; discard if cloudy or particulate
- Label the vial with the reconstitution date; store at 2–8°C and use within 28 days
- Wipe the vial stopper with a fresh alcohol swab before each draw; use an insulin syringe to draw the target volume
- Pinch a small fold of skin at the injection site (abdomen or thigh), insert the needle at a 45–90 degree angle, and inject slowly over 5–10 seconds
- Apply gentle pressure with a clean swab after withdrawing the needle; do not rub the site
- Rotate injection sites with each dose to prevent localized irritation
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Cycle
The Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- NA-Semax/Selank effects may be noticeable quickly (focus, anxiety reduction)
- Week 1-2
- Cognitive enhancement and mood effects develop
- Week 2-4
- Neuritogenic and BDNF effects building
- Week 4-8
- Full protocol benefits; assess and cycle off
Dosing tools
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)Blend Dosage Calculator
Calculate blended peptide doses with our visual syringe guide.
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
1 mL
2 mL
3 mL
5 mL
Custom
Blend Composition
Total: 20.0 mg
mg
mg
The compound you want to dose by. Results will be calculated based on this compound.
The dose of the anchor compound you want per administration, in mcg or mg.
Conversion: 1,000 mcg = 1 mg
Results
Concentration
20.00
mg/mL
Doses per vial
40
Total blend to inject
0.50
mg
You'll get:
- PE-22-28
- 250 mcgANCHOR
- Pinealon
- 250 mcg
1mL / 100 units
2 units
0.025 mL
Dosing Guidance
Recommended Schedule
once daily
Supply Duration
This vial provides 40 doses (40-day supply at 250 mcg daily)
Peptide Interactions
Research suggestions of Selank, Semax, Pinealon, PE-22-28 (Illumineuro) interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Different targets; BPC-157 may complement with healing/gut-brain effects.
Cognitive
dih
Longevity
Dihexa
MONITOR
Both highly neuroactive; use caution combining multiple cognitive enhancers.
Longevity
epi
Immunity
Epitalon
COMPATIBLE
Complementary pineal/longevity support; different mechanisms.
Side effects
Monitor: Be careful when combining Selank, Semax, Pinealon, PE-22-28 (Illumineuro) with Dihexa.
Contraindications
No clinical trials on four-peptide combination
Bipolar disorder or psychosis (caution with cognitive enhancers)
Pregnancy or breastfeeding
Seizure disorders (theoretical concern)
Stop signs
Severe headaches
Significant mood changes
Allergic reactions
Cognitive impairment instead of enhancement
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)Research References
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) is an experimental compound
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) is an experimental compound
PE-22-28 Neuritogenic Effects
PE-22-28 promotes neurite outgrowth through S1P receptor modulation.
n.d.
NA-Semax Amidate Cognitive Enhancement
Enhanced stability amidate form of Semax with BDNF upregulation and neuroprotective effects.
n.d.
NA-Selank Amidate Anxiolytic Properties
Selank demonstrates anxiolytic effects through GABA modulation and immune-neuroendocrine regulation.
n.d.
Pinealon Bioregulator
Pinealon (EDR tripeptide) supports pineal gland function and circadian regulation.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
