Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
FDA APPROVAL PENDING
Limited Research
Cognitive
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
25
Amino acids
Molecular weight
Blend
Type
IllumiNeuro is a cognitive enhancement peptide blend combining four nootropic peptides: PE-22-28 (neuritogenic), Pinealon (pineal bioregulator), NA-Semax Amidate (neuroprotective/cognitive), and NA-Selank Amidate (anxiolytic/cognitive). The standard formulation contains 48mg total (PE-22-28 10mg + Pinealon 10mg + NA-Semax 20mg + NA-Selank 8mg). This blend targets multiple neurological pathways for comprehensive cognitive support, though no clinical studies exist on this specific four-peptide combination.
Top researched benefits
Overview of Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Each peptide contributes distinct neurological mechanisms: PE-22-28 promotes neurite outgrowth and neural connectivity through sphingosine-1-phosphate receptor modulation; Pinealon is a bioregulator that supports pineal gland function and circadian regulation; NA-Semax Amidate provides BDNF upregulation and neuroprotection; NA-Selank Amidate offers anxiolytic effects through GABA modulation and immune-neuroendocrine regulation. Together, they theoretically address cognitive enhancement, neuroprotection, mood support, and neural regeneration.
cognitive enhancement
- Combined BDNF support and neuritogenic effects may enhance memory formation and learning.
- NA-Semax component supports sustained attention and mental clarity.
- Multiple pathways protecting neural tissue from oxidative stress and damage.
mood and anxiety
- NA-Selank provides anxiolytic effects through GABA modulation.
- Immune-neuroendocrine support helps with stress resilience.
- Combined effects on neurotransmitter systems may improve overall mood.
neural health
- PE-22-28 promotes neural connectivity and neurite extension.
- Pinealon supports healthy sleep-wake cycles and pineal function.
Typical Dose
100-500 mcg total blend per day
Frequency
Once daily, preferably in the morning for cognitive benefits
Cycle Duration
4-8 weeks
Storage
Lyophilized: Room temperature. Reconstituted: 2-8°C, use within 4 weeks
Chemical Makeup
Key benefits
Multi-pathway cognitive enhancement
Neuroprotective and neuritogenic effects
Anxiolytic properties from NA-Selank
BDNF upregulation from NA-Semax
Circadian/sleep support from Pinealon
Convenience of single injection
Extended-action amidate forms included
Community interest
This peptide is still gaining traction in the community.
Four-Peptide Cognitive Enhancement Blend
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoSelank, Semax, Pinealon, PE-22-28 (Illumineuro) Molecular Information
View the scientifc details of Selank, Semax, Pinealon, PE-22-28 (Illumineuro).
25
Amino Acids
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Pro
Pro
Position 1
Glu
Glu
Position 2
Pro
Pro
Position 3
Ile
Ile
Position 4
Asn
Asn
Position 5
Glu
Glu
Position 6
Ala
Ala
Position 7
Leu
Leu
Position 8
Pyl
Pyl
Position 9
Asn
Asn
Position 10
Asn
Asn
Position 11
Ala
Ala
Position 12
Ser
Ser
Position 13
Glu
Glu
Position 14
Met
Met
Position 15
Ala
Ala
Position 16
?
?
Position 17
Asn
Asn
Position 18
Ala
Ala
Position 19
Ser
Ser
Position 20
Glu
Glu
Position 21
Leu
Leu
Position 22
Ala
Ala
Position 23
Asn
Asn
Position 24
Lys
Lys
Position 25
Molecular Weight
0DaChain Length
25Amino AcidsType
BlendSelank, Semax, Pinealon, PE-22-28 (Illumineuro) Protocols
Intranasal delivery provides more direct access to the CNS. The component peptides (especially Semax and Selank) have established intranasal protocols.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Intranasal cognitive | 100 | 1 week range | Intranasal spray |
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Cycle
The Selank, Semax, Pinealon, PE-22-28 (Illumineuro) Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- NA-Semax/Selank effects may be noticeable quickly (focus, anxiety reduction)
- Week 1-2
- Cognitive enhancement and mood effects develop
- Week 2-4
- Neuritogenic and BDNF effects building
- Week 4-8
- Full protocol benefits; assess and cycle off
Dosing tools
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)Blend Dosage Calculator
Calculate blended peptide doses with our visual syringe guide.
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
1 mL
2 mL
3 mL
5 mL
Custom
Custom Blend Compounds
Total: 20.0 mg
mg
mg
The dose of the anchor peptide you want per administration, in mcg or mg.
Conversion: 1,000 mcg = 1 mg
Results
Concentration
20.00
mg/mL
Doses per vial
40
Total blend to inject
0.50
mg
You'll get:
- PE-22-28
- 250 mcgANCHOR
- Pinealon
- 250 mcg
1mL / 100 units
2 units
0.025 mL
Dosing Guidance
Recommended Schedule
Once daily, preferably in the morning for cognitive benefits
Supply Duration
This vial provides 40 doses (40-day supply at 250 mcg daily)
Peptide Interactions
Research suggestions of Selank, Semax, Pinealon, PE-22-28 (Illumineuro) interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Different targets; BPC-157 may complement with healing/gut-brain effects.
Cognitive
dih
Longevity
Dihexa
MONITOR
Both highly neuroactive; use caution combining multiple cognitive enhancers.
Longevity
epi
Immunity
Epitalon
COMPATIBLE
Complementary pineal/longevity support; different mechanisms.
Side effects
Monitor: Be careful when combining Selank, Semax, Pinealon, PE-22-28 (Illumineuro) with Dihexa.
Contraindications
No clinical trials on four-peptide combination
Bipolar disorder or psychosis (caution with cognitive enhancers)
Pregnancy or breastfeeding
Seizure disorders (theoretical concern)
Stop signs
Severe headaches
Significant mood changes
Allergic reactions
Cognitive impairment instead of enhancement
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)Research References
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) is a limited research compound
Selank, Semax, Pinealon, PE-22-28 (Illumineuro)
Selank, Semax, Pinealon, PE-22-28 (Illumineuro) is a limited research compound
PE-22-28 Neuritogenic Effects
PE-22-28 promotes neurite outgrowth through S1P receptor modulation.
n.d.
NA-Semax Amidate Cognitive Enhancement
Enhanced stability amidate form of Semax with BDNF upregulation and neuroprotective effects.
n.d.
NA-Selank Amidate Anxiolytic Properties
Selank demonstrates anxiolytic effects through GABA modulation and immune-neuroendocrine regulation.
n.d.
Pinealon Bioregulator
Pinealon (EDR tripeptide) supports pineal gland function and circadian regulation.
n.d.