Cognitive
Adalank
Longevity
7
Amino acids
Molecular weight
Peptide
Type
Adalank (N-Acetyl Selank Amidate; Ac-TKPRPGP-NH2) is a synthetically modified derivative of the Russian neuropeptide Selank, featuring N-terminal acetylation and C-terminal amidation that increase blood-brain barrier penetration and enzymatic stability. It acts as a positive allosteric modulator of GABA-A receptors and upregulates hippocampal BDNF to reduce anxiety and enhance cognition. Researchers study it as a non-sedating anxiolytic with potential advantages over benzodiazepines due to its lack of dependency risk.
Top researched benefits
Overview of Adalank
Adalank acts as a positive allosteric modulator of GABA-A receptors, enhancing GABA binding affinity at a site distinct from the benzodiazepine binding site, while also upregulating BDNF expression in the hippocampus and inhibiting enkephalin-degrading enzymes. The N-acetyl and C-terminal amide modifications increase lipophilicity and resistance to aminopeptidase cleavage, enabling improved passive diffusion across the blood-brain barrier compared to parent Selank.
anxiety
- Clinical trials showed effects comparable to benzodiazepines; 40% rapid response within 1-3 days.
- Reduces stress hormones and balances neurotransmitters without sedation.
- Unlike benzodiazepines, provides relief without tolerance, withdrawal, or dependency.
cognitive
- Improves focus, attention, and mental clarity.
- BDNF-mediated neuroplasticity supports memory formation.
neuroprotection
- Rapidly elevates BDNF expression, supporting neuronal survival.
- Enhances ability to cope with psychological stress.
Typical Dose
200–500mcg per administration
Frequency
once or twice daily
Cycle Duration
2–4 weeks on, 1–2 weeks off
Storage
Lyophilized: -20°C long-term or 2–8°C short-term. Reconstituted: 2–8°C for up to 14–30 days.
Chemical Makeup
Key benefits
Produces anxiolytic effects comparable to benzodiazepines (e.g., medazepam) without sedation, tolerance, or dependency risk
Upregulates hippocampal BDNF, supporting neuronal survival, synaptic plasticity, and memory consolidation
Enhances cognitive performance including learning, memory retention, and mental clarity via neuromodulation of dopamine and serotonin systems
Improves stress resilience by modulating the HPA axis stress response and reducing cortisol-driven anxiety behaviors
Community interest
This peptide is still gaining traction in the community.
Enhanced Selank Analog | Anxiolytic & Nootropic
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoAdalank Molecular Information
View the scientifc details of Adalank.
7
Amino Acids
Adalank
Thr
Thr
Position 1
Lys
Lys
Position 2
Pro
Pro
Position 3
Arg
Arg
Position 4
Pro
Pro
Position 5
Gly
Gly
Position 6
Pro
Pro
Position 7
Molecular Weight
792.93DaChain Length
7Amino AcidsType
PeptideAdalank Protocols
Subcutaneous injection is the primary research-grade delivery route for Adalank, offering precise dosing and reliable systemic absorption. Preferred injection sites include the belly, thigh, or upper arm, with morning administration timed to align Adalank's GABAergic anxiolytic action with peak daily cognitive demand.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Anxiety Reduction | 250 | 1 day range | SubQ |
| Cognitive Enhancement | 350 | 1 day range | SubQ |
| Stress Management | 250 | 2 day range | SubQ |
| Initial / Beginner Trial | 150 | 1 day range | SubQ |
| Neuroprotection | 300 | 1 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clean the work area and wipe both the BAC water vial and Adalank vial stoppers with alcohol swabs
- Calculate the volume of bacteriostatic water needed based on your target dose — a common ratio is 2 mL BAC water per 5 mg vial, giving 2500 mcg/mL
- Draw the calculated volume of BAC water into an insulin syringe
- Insert the needle into the Adalank vial and inject the BAC water slowly down the inner side of the vial — never aim directly onto the powder
- Gently swirl the vial in a circular motion until the powder is fully dissolved — do not shake vigorously
- Refrigerate the reconstituted solution immediately at 2–8°C and use within 14–30 days
- Draw your target dose into an insulin syringe, pinch the skin at the injection site, and inject subcutaneously at a 45-degree angle
- Rotate injection sites with each administration to avoid local tissue irritation
Adalank Cycle
The Adalank Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- 40% may experience rapid anxiety reduction
- Week 1-2
- Gradual anxiety relief, improved mood, enhanced stress resilience
- Week 2-4
- Cognitive enhancement, improved focus, BDNF-mediated neuroplasticity
- Week 0-0
- Sustained anxiolytic and cognitive benefits
Dosing tools
Adalank Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Adalank
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Adalank vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Adalank
- Dosing
- 200–500mcg per administration
- Dosing Frequency
- once or twice daily
- Cycle Duration
- 2–4 weeks on, 1–2 weeks off
- Storage
- Lyophilized: -20°C long-term or 2–8°C short-term. Reconstituted: 2–8°C for up to 14–30 days.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Adalank interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Different mechanisms; Adalank targets neurological pathways, BPC-157 focuses on tissue repair.
Cognitive
sel
Longevity
Selank
COMPATIBLE
Adalank is enhanced derivative with improved stability and longer half-life.
Cognitive
sema
Longevity
Semax
COMPATIBLE
Both are Russian nootropic peptides with different mechanisms.
Side effects
Contraindications
Experimental peptide with limited direct human research on N-Acetyl form
Not recommended during pregnancy or breastfeeding
Consult healthcare provider before use with psychiatric medications
Stop signs
Unusual or persistent headaches
Significant mood changes or depression
Unexpected sedation or extreme fatigue
Unusual neurological symptoms
Persistent injection site reactions or nasal irritation
Severe gastrointestinal distress
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
AdalankResearch References
Adalank is an experimental compound
Adalank
Adalank is an experimental compound
Selank for GAD - Non-inferiority Trial
62 patients with GAD; 2700mcg/day intranasal; 14 days. Anxiolytic effects comparable to medazepam; 40% rapid response within 1-3 days.
n.d.
Selank and BDNF Regulation in Hippocampus
Rat study; intranasal administration. Rapidly elevated BDNF expression, confirming neurotrophin involvement.
n.d.
Peptide Selank Enhances Diazepam Effects
Rats in chronic mild stress model. Enhanced anxiolytic effects while reducing memory impairment and sedation.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
