Cognitive
Selank
Longevity
7
Amino acids
Molecular weight
Peptide
Type
Selank is a synthetic heptapeptide analogue of tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, approved in Russia for the treatment of generalized anxiety disorder and neurasthenia. It modulates the GABAergic system and elevates BDNF in the hippocampus, producing anxiolytic effects comparable to benzodiazepines without sedation, tolerance, or dependence. It is used in both clinical settings and by biohackers seeking nootropic and anxiolytic benefits.
Top researched benefits
Overview of Selank
Selank allosterically modulates GABA-A receptors, mimicking the calming action of benzodiazepines while also inhibiting enkephalin-degrading enzymes and elevating BDNF expression in the hippocampus. It additionally influences serotonin, dopamine, and norepinephrine turnover, supporting attention, learning, and mood regulation without causing receptor downregulation or dependence.
anxiety
- Clinical trials show significant reduction in anxiety symptoms comparable to benzodiazepines but without sedation or amnesia.
- Research indicates effectiveness in PTSD treatment.
- Reduces anticipatory anxiety and performance stress.
cognitive
- Improves memory consolidation and learning capacity.
- Enhanced sustained attention during demanding cognitive tasks.
- BDNF upregulation supports long-term brain health.
immune
- Balances immune system function through cytokine regulation.
- Shows activity against influenza, HSV, and cytomegalovirus.
- Modulates inflammatory gene expression.
Typical Dose
750mcg per day (split across doses)
Frequency
once daily in divided doses
Cycle Duration
10–14 days on, followed by a break to prevent tolerance
Storage
Lyophilized: -20°C for up to 24 months; stable at room temperature for up to 3 weeks. Reconstituted: 2–8°C for 2–7 days; do not freeze reconstituted solution.
Chemical Makeup
Key benefits
Reduces generalized anxiety with efficacy comparable to medazepam, without sedation or risk of dependence or withdrawal
Enhances working memory, concentration, and learning capacity by elevating BDNF levels in the hippocampus
Inhibits enzymes that degrade enkephalins and other endogenous regulatory peptides, prolonging their mood-stabilizing effects
Modulates serotonin, dopamine, and norepinephrine to improve motivation, vigilance, and stress resilience
Community interest
This peptide is still gaining traction in the community.
Anxiolytic Nootropic | Anxiety & Cognitive Enhancement
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoSelank Molecular Information
View the scientifc details of Selank.
7
Amino Acids
Selank
Thr
Thr
Position 1
Lys
Lys
Position 2
Pro
Pro
Position 3
Arg
Arg
Position 4
Pro
Pro
Position 5
Gly
Gly
Position 6
Pro
Pro
Position 7
Molecular Weight
751.89DaChain Length
7Amino AcidsType
PeptideSelank Protocols
Sublingual administration of Selank solution is used as a non-injection alternative for those unable to use nasal spray, though it achieves only 10–25% bioavailability due to enzymatic degradation. Hold the solution under the tongue for 60–90 seconds to allow absorption through the sublingual mucosa.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Anxiety relief | 500 | 2 day range | Sublingual |
| Cognitive enhancement | 400 | 2 day range | Sublingual |
| Stress management | 750 | 2 day range | Sublingual |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Reconstitute Selank powder with bacteriostatic water or draw from a pre-prepared solution into a 1 mL dropper or oral syringe
- Avoid eating or drinking for at least 30 minutes before sublingual administration
- Place the measured dose of solution under the tongue using the dropper
- Hold the solution under the tongue without swallowing for 60–90 seconds to allow mucosal absorption
- Swallow any remaining solution after the hold period
- Avoid eating, drinking, or rinsing the mouth for 15 minutes after administration
Selank Cycle
The Selank Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Mild anxiety reduction begins
- Week 0-0
- Improved mental clarity and focus
- Week 0-0
- Enhanced stress resilience and emotional stability
- Week 0-0
- Peak cognitive enhancement effects
- Week 0-0
- Sustained benefits for several days
Dosing tools
Selank Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Selank
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Selank vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Selank
- Dosing
- 750mcg per day (split across doses)
- Dosing Frequency
- once daily in divided doses
- Cycle Duration
- 10–14 days on, followed by a break to prevent tolerance
- Storage
- Lyophilized: -20°C for up to 24 months; stable at room temperature for up to 3 weeks. Reconstituted: 2–8°C for 2–7 days; do not freeze reconstituted solution.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Selank interactions with other common peptides and substances.
Cognitive
sema
Longevity
Semax
SYNERGISTIC
Enhanced cognitive and anxiolytic effects when combined.
Side effects
Contraindications
Known peptide allergies
Pregnancy or breastfeeding
Consult healthcare provider with multiple psychiatric medications
Stop signs
Severe allergic reactions (rash, breathing difficulty, swelling)
Persistent injection site reactions or infection signs
Unusual mood changes or increased anxiety
Severe headaches or neurological symptoms
Contaminated product signs (unusual smell, cloudiness)
Unexplained fatigue or cognitive impairment
Skin reactions or immune hypersensitivity
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
SelankResearch References
Selank is an approved compound
Selank
Selank is an approved compound
GABAergic Gene Expression Study
Rat frontal cortex study at 300mcg/kg showed modulation of 45 genes involved in neurotransmission; GABAergic mechanism confirmed.
2016
GAD Clinical Trial
Human subjects showed significant anxiolytic and mild nootropic effects lasting up to one week post-administration.
2008
BDNF Enhancement Study
Rat hippocampus study at 250-500mcg/kg showed 30% increase in hippocampal BDNF levels.
2010
Memory Consolidation Study
Significant activation of learning processes in subjects with poor initial learning.
2007
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
