Longevity
Thymosin Alpha 1
Immunity
28
Amino acids
Molecular weight
Peptide
Type
Thymosin Alpha 1 is a synthetic 28-amino acid peptide identical to naturally occurring thymic hormone, studied in 11,000+ patients across 30+ clinical trials with less than 1% serious adverse events. Approved in 35+ countries for immune modulation.
Top researched benefits
Overview of Thymosin Alpha 1
Activates TLR pathways, enhances T-cell maturation, stimulates NK cells, and modulates dendritic cell function via systemic circulation. Injectable route achieves 90-95% bioavailability with 2-hour peak time.
immunity
- FDA orphan designation for DiGeorge syndrome; restores T-cell function.
- Improved antibody responses in elderly and hemodialysis patients (H1N1, COVID-19).
- Restores CD4+ counts and reduces opportunistic infections.
inflammation
- Reduces pro-inflammatory cytokines TNF-α, IL-1β, IL-6 by 40-60%.
- Enhanced antiviral efficacy when combined with interferon.
- Helps manage inflammatory autoimmune conditions.
recovery
- Restores immune function after surgical stress.
- Manages immune suppression from intense training.
antiaging
- Supports thymus gland function with aging.
- Delays age-related immune decline in elderly populations.
Typical Dose
1.6mg per injection (standard dose across all protocols)
Frequency
2x weekly (e.g., Monday and Thursday) for standard immune support
Cycle Duration
6 months continuous for therapeutic protocols
Storage
Use immediately after reconstitution or refrigerate up to 2 hours
Chemical Makeup
Key benefits
Primary FDA-studied route with extensive clinical validation
Maximum immune modulation through systemic circulation
Established dosing from 35+ countries of clinical use
Exceptional safety profile (<1% serious adverse events)
Reduces pro-inflammatory cytokines 40-60%
Approved in 35+ countries
Community interest
This peptide is still gaining traction in the community.
Synthetic Thymic Hormone | Immune System Modulator
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoThymosin Alpha 1 Molecular Information
View the scientifc details of Thymosin Alpha 1.
28
Amino Acids
Thymosin Alpha 1
Ser
Ser
Position 1
Asp
Asp
Position 2
Ala
Ala
Position 3
Ala
Ala
Position 4
Val
Val
Position 5
Asp
Asp
Position 6
Thr
Thr
Position 7
Ser
Ser
Position 8
Ser
Ser
Position 9
Glu
Glu
Position 10
Ile
Ile
Position 11
Thr
Thr
Position 12
Thr
Thr
Position 13
Lys
Lys
Position 14
Asp
Asp
Position 15
Leu
Leu
Position 16
Lys
Lys
Position 17
Glu
Glu
Position 18
Lys
Lys
Position 19
Lys
Lys
Position 20
Glu
Glu
Position 21
Val
Val
Position 22
Val
Val
Position 23
Glu
Glu
Position 24
Glu
Glu
Position 25
Ala
Ala
Position 26
Glu
Glu
Position 27
Asn
Asn
Position 28
Molecular Weight
3DaChain Length
28Amino AcidsType
PeptideThymosin Alpha 1 Protocols
Subcutaneous injection is the primary route with 90-95% bioavailability. Standard dosing is 1.6mg twice weekly.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard immune support | 1.6 | 2 week range | SubQ |
| Acute conditions (sepsis) | 1.6 | 2 week range | SubQ/IM |
| Cancer/hepatitis support | 1.6 | 2 week range | SubQ |
| Maintenance/prevention | 1.6 | 2 week range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clean work surface thoroughly
- Add 1.0mL sterile water slowly to lyophilized powder
- Inject water down vial side (avoid direct powder contact)
- Gently swirl until fully dissolved (never shake)
- Final concentration: 1.6mg/mL
- Use immediately or refrigerate up to 2 hours
Thymosin Alpha 1 Cycle
The Thymosin Alpha 1 Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Initial immune system activation
- Week 2-6
- Enhanced immune function, reduced infection risk
- Week 6-12
- Maximum immunomodulatory benefits
- Week 0-0
- Sustained immune support with continued use
Dosing tools
Thymosin Alpha 1 Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Thymosin Alpha 1
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Thymosin Alpha 1 vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Thymosin Alpha 1
- Dosing
- 1.6mg per injection (standard dose across all protocols)
- Dosing Frequency
- 2x weekly (e.g., Monday and Thursday) for standard immune support
- Cycle Duration
- 6 months continuous for therapeutic protocols
- Storage
- Use immediately after reconstitution or refrigerate up to 2 hours
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Side effects
Contraindications
Organ transplant recipients (risk of graft rejection)
Pregnancy and breastfeeding
Stop signs
Signs of graft rejection in transplant recipients
Persistent injection site reactions or infection signs
Unusual immune system hyperactivity
Severe allergic reactions (rare)
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
Thymosin Alpha 1Research References
Thymosin Alpha 1 is a well studied compound
Thymosin Alpha 1
Thymosin Alpha 1 is a well studied compound
COVID-19 Treatment Study
30% vs 11% mortality reduction in severe cases; lymphocyte restoration.
2020
TESTS Phase 3 Sepsis Trial
1,106 patients; mixed overall results but subgroup benefits in elderly/diabetic populations.
2020
Cytokine Storm Mitigation Study
40-60% reduction in pro-inflammatory cytokines (TNF-α, IL-1β, IL-6).
2020
Comprehensive Safety Review
11,000+ patients, 30+ trials; <1% serious adverse events.
2024