Growth
Tesamorelin/Ipamorelin
Metabolic
35
Amino acids
Molecular weight
Blend
Type
Tesamorelin/Ipamorelin is a synergistic peptide blend combining a GHRH analogue (Tesamorelin) with a selective ghrelin mimetic (Ipamorelin) to amplify endogenous growth hormone release through two distinct receptor pathways. Tesamorelin is FDA-approved (EGRIFTA) for HIV-associated lipodystrophy and has demonstrated 15–17.5% visceral fat reduction in clinical trials; Ipamorelin adds pulsatile GH stimulation without elevating cortisol or prolactin. The stack is used in clinical and functional medicine settings for body recomposition, metabolic improvement, and anti-aging hormone optimization.
Top researched benefits
Overview of Tesamorelin/Ipamorelin
Tesamorelin binds pituitary GHRH receptors to restore physiologic GH pulses and raise IGF-1, while Ipamorelin activates ghrelin/GHS-R1a receptors to initiate a separate GH pulse at the somatotroph. The dual-pathway stimulation produces a synergistic GH response greater than either compound alone, as the GHRP-initiated pulse is amplified by simultaneous GHRH-receptor activation.
body composition
- Tesamorelin has demonstrated fat reduction in clinical trials; synergy with Ipamorelin may enhance effects.
- Tesamorelin specifically reduces visceral adipose tissue (FDA-approved indication).
- Enhanced GH promotes protein synthesis and lean tissue preservation.
recovery and wellness
- GH secretagogues often improve deep sleep quality.
- Enhanced GH supports tissue repair and recovery from exercise.
- Restoring more youthful GH levels may provide anti-aging benefits.
metabolic health
- Tesamorelin has shown improvements in lipid parameters in studies.
- Increased GH leads to increased IGF-1 production.
Typical Dose
300mcg Tesamorelin + 100mcg Ipamorelin per injection
Frequency
twice daily (morning and evening, fasted)
Cycle Duration
8 weeks on, 8 weeks off; 5 days on, 2 days off weekly
Storage
Lyophilized powder: store at -20°C (up to 18–24 months) or 2–8°C. Reconstituted with bacteriostatic water: refrigerate at 2–8°C, protected from light, use within 28 days. Do not freeze reconstituted solution.
Chemical Makeup
Key benefits
Reduces visceral adipose tissue by approximately 15–17.5% over 26–52 weeks, with clinical trial data showing superiority over placebo in HIV lipodystrophy populations
Increases lean body mass by approximately 1.42 kg through sustained elevation of GH and IGF-1 without exogenous GH administration
Ipamorelin selectively stimulates GH release without significantly raising cortisol, ACTH, or prolactin, making the combination suitable for longer cycles compared to non-selective GHRPs
Dual-pathway GH stimulation mimics the natural youthful pulsatile rhythm of GH secretion, producing a synergistic GH release greater than either compound used alone
Community interest
This peptide is still gaining traction in the community.
GHRH + GHS Dual-Pathway Blend | Fat Loss & GH Optimization
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoTesamorelin/Ipamorelin Molecular Information
View the scientifc details of Tesamorelin/Ipamorelin .
35
Amino Acids
Tesamorelin/Ipamorelin
Thr
Thr
Position 1
Glu
Glu
Position 2
Ser
Ser
Position 3
Ala
Ala
Position 4
Met
Met
Position 5
Pyl
Pyl
Position 6
Arg
Arg
Position 7
Glu
Glu
Position 8
Leu
Leu
Position 9
Ile
Ile
Position 10
Asn
Asn
Position 11
Gly
Gly
Position 12
His
His
Position 13
Arg
Arg
Position 14
His
His
Position 15
Ala
Ala
Position 16
Asn
Asn
Position 17
Ala
Ala
Position 18
Leu
Leu
Position 19
Pyl
Pyl
Position 20
Gly
Gly
Position 21
Ile
Ile
Position 22
Pro
Pro
Position 23
Ala
Ala
Position 24
Met
Met
Position 25
Pyl
Pyl
Position 26
Arg
Arg
Position 27
Glu
Glu
Position 28
Leu
Leu
Position 29
Ile
Ile
Position 30
Asn
Asn
Position 31
Gly
Gly
Position 32
His
His
Position 33
Arg
Arg
Position 34
Pro
Pro
Position 35
Molecular Weight
5135.9DaChain Length
35Amino AcidsType
BlendTesamorelin/Ipamorelin Protocols
Subcutaneous injection into the lower abdomen is the only clinically documented route for the Tesamorelin/Ipamorelin blend. The combination is administered fasted at least 2–3 hours after the last meal — ideally 30–90 minutes before sleep — to amplify the natural nocturnal GH pulse through dual GHRH/ghrelin-mimetic pathway activation.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Visceral fat reduction — entry dose | 0.375 | 1 day range | SubQ abdomen |
| Visceral fat reduction — titration mid | 0.75 | 1 day range | SubQ abdomen |
| Body composition and lean mass | 1.5 | 1 day range | SubQ abdomen |
| GH optimization and anti-aging | 2.25 | 1 day range | SubQ abdomen |
| Advanced body recomposition — full dose | 3 | 1 day range | SubQ abdomen |
| Sleep quality and recovery — female low dose | 0.2 | 1 day range | SubQ abdomen |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Remove the blend vial from the refrigerator and allow it to reach room temperature for 5–10 minutes before reconstitution
- Wipe the rubber stopper of both the peptide vial and the bacteriostatic water vial with a fresh alcohol swab and allow to air dry for 30 seconds
- Draw 3.0 mL of bacteriostatic water into a 3 mL syringe with an 18–21 gauge needle — this yields approximately 3.33 mg/mL total (1.67 mg/mL each peptide) in a 10 mg blend vial
- Insert the syringe needle through the stopper at an angle and inject the bacteriostatic water slowly down the inner glass wall of the vial — never shoot it directly onto the powder
- Remove the syringe and gently swirl or roll the vial between your palms for 30–60 seconds until the powder fully dissolves — do not shake
- Inspect the reconstituted solution — it should be clear and colorless with no visible particles; discard if cloudy or particulate
- Using a fresh insulin syringe, draw the calculated dose volume from the reconstituted vial and expel any air bubbles
- Pinch a fold of skin at the lower abdomen at least 2 inches from the navel, insert the needle at 90 degrees (or 45 degrees if lean), inject slowly, then remove and apply light pressure with a gauze pad
- Rotate injection sites systematically — left abdomen, right abdomen, outer thighs, upper arms — to prevent lipohypertrophy
- Cap the used syringe and dispose in a sharps container; return the reconstituted vial to the refrigerator and use within 28 days
Tesamorelin/Ipamorelin Cycle
The Tesamorelin/Ipamorelin Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Improved sleep quality often noticed first; initial GH response
- Week 2-4
- Enhanced recovery; subtle body composition changes beginning
- Week 4-8
- Noticeable fat loss (especially visceral); improved energy
- Week 8-16
- Full body composition benefits; continued improvements
Dosing tools
Tesamorelin/Ipamorelin Blend Dosage Calculator
Calculate blended peptide doses with our visual syringe guide.
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
1 mL
2 mL
3 mL
5 mL
Custom
Blend Composition
Total: 10.0 mg
mg
mg
The compound you want to dose by. Results will be calculated based on this compound.
The dose of the anchor compound you want per administration, in mcg or mg.
Conversion: 1,000 mcg = 1 mg
Results
Concentration
10.00
mg/mL
Doses per vial
20
Total blend to inject
0.50
mg
You'll get:
- Ipamorelin
- 250 mcgANCHOR
- Tesamorelin
- 250 mcg
1mL / 100 units
5 units
0.050 mL
Dosing Guidance
Recommended Schedule
twice daily (morning and evening, fasted)
Supply Duration
This vial provides 20 doses (20-day supply at 250 mcg daily)
Peptide Interactions
Research suggestions of Tesamorelin/Ipamorelin interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Different mechanisms; can complement for healing with GH support.
Weight
mk6
Growth
MK-677
MONITOR
Both affect GH release; combination may be excessive and affect glucose.
Weight
GLP-1
Metabolic
GLP-1
COMPATIBLE
Different pathways; some combine for body composition goals.
Side effects
Monitor: Be careful when combining Tesamorelin/Ipamorelin with MK-677.
Contraindications
Active malignancy (GH may promote tumor growth)
Diabetic retinopathy
Pregnancy or breastfeeding
Pituitary disorders
Hypersensitivity to components
Stop signs
Severe injection site reactions
Significant swelling or edema
Signs of glucose dysregulation
Severe joint pain
Allergic reactions
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
Tesamorelin/Ipamorelin Research References
Tesamorelin/Ipamorelin is a phase 3 compound
Tesamorelin/Ipamorelin
Tesamorelin/Ipamorelin is a phase 3 compound
Tesamorelin FDA Approval for HIV Lipodystrophy
Tesamorelin (Egrifta) approved for reduction of excess abdominal fat in HIV patients.
n.d.
Tesamorelin Effects on Visceral Fat
Tesamorelin significantly reduces visceral adipose tissue and improves lipid profiles.
n.d.
Ipamorelin Selectivity Profile
Ipamorelin selectively releases GH without affecting cortisol, prolactin, or ACTH.
n.d.
GHRH + GHRP Synergy
Combining GHRH and GHRP pathways produces synergistic GH release greater than either alone.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
