Growth
Tesamorelin/Ipamorelin
Metabolic
35
Amino acids
Molecular weight
Blend
Type
The Tesa/IPA blend combines two complementary growth hormone secretagogues: Tesamorelin (a GHRH analog that stimulates GH release from the pituitary) and Ipamorelin (a selective ghrelin mimetic/GHRP that amplifies GH pulses). This combination addresses both the GHRH and GHRP pathways for synergistic GH release. Common formulations include 5mg/5mg (1:1 ratio) and 10mg/3mg (higher Tesamorelin) variants. Tesamorelin is FDA-approved for HIV-associated lipodystrophy, while Ipamorelin remains investigational.
Top researched benefits
Overview of Tesamorelin/Ipamorelin
The blend leverages two distinct GH-releasing pathways: Tesamorelin is a synthetic GHRH analog that directly stimulates growth hormone-releasing hormone receptors on pituitary somatotrophs, triggering GH synthesis and secretion in a pulsatile, physiological manner. Ipamorelin is a selective ghrelin receptor (GHS-R1a) agonist that amplifies GH pulses without significantly affecting cortisol or prolactin. Together, they produce synergistic GH release greater than either compound alone, while maintaining the body's natural feedback mechanisms.
body composition
- Tesamorelin has demonstrated fat reduction in clinical trials; synergy with Ipamorelin may enhance effects.
- Tesamorelin specifically reduces visceral adipose tissue (FDA-approved indication).
- Enhanced GH promotes protein synthesis and lean tissue preservation.
recovery and wellness
- GH secretagogues often improve deep sleep quality.
- Enhanced GH supports tissue repair and recovery from exercise.
- Restoring more youthful GH levels may provide anti-aging benefits.
metabolic health
- Tesamorelin has shown improvements in lipid parameters in studies.
- Increased GH leads to increased IGF-1 production.
Typical Dose
200-500mcg total blend per injection
Frequency
Once daily (evening preferred) or twice daily for advanced protocols
Cycle Duration
8-16 weeks continuous
Storage
Reconstituted: 2-8°C, use within 4-6 weeks
Chemical Makeup
Key benefits
Synergistic GH release from dual pathways
More physiological pulsatile GH secretion
Tesamorelin's proven lipodystrophy benefits
Ipamorelin's clean side effect profile
Does not significantly affect cortisol or prolactin
Single injection convenience
May improve body composition, sleep, and recovery
Community interest
This peptide is still gaining traction in the community.
Tesamorelin + Ipamorelin GH Secretagogue Blend
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoTesamorelin/Ipamorelin Molecular Information
View the scientifc details of Tesamorelin/Ipamorelin .
35
Amino Acids
Tesamorelin/Ipamorelin
Thr
Thr
Position 1
Glu
Glu
Position 2
Ser
Ser
Position 3
Ala
Ala
Position 4
Met
Met
Position 5
Pyl
Pyl
Position 6
Arg
Arg
Position 7
Glu
Glu
Position 8
Leu
Leu
Position 9
Ile
Ile
Position 10
Asn
Asn
Position 11
Gly
Gly
Position 12
His
His
Position 13
Arg
Arg
Position 14
His
His
Position 15
Ala
Ala
Position 16
Asn
Asn
Position 17
Ala
Ala
Position 18
Leu
Leu
Position 19
Pyl
Pyl
Position 20
Gly
Gly
Position 21
Ile
Ile
Position 22
Pro
Pro
Position 23
Ala
Ala
Position 24
Met
Met
Position 25
Pyl
Pyl
Position 26
Arg
Arg
Position 27
Glu
Glu
Position 28
Leu
Leu
Position 29
Ile
Ile
Position 30
Asn
Asn
Position 31
Gly
Gly
Position 32
His
His
Position 33
Arg
Arg
Position 34
Pro
Pro
Position 35
Molecular Weight
0DaChain Length
35Amino AcidsType
BlendTesamorelin/Ipamorelin Protocols
Subcutaneous injection, typically administered before bed or in the morning on an empty stomach. Evening dosing may enhance natural nighttime GH pulse. Avoid eating 2-3 hours before and 30-60 minutes after injection for optimal results.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard protocol (5/5 blend) | 200 | 1 week range | SubQ |
| Enhanced protocol (10/3 blend) | 300 | 1 week range | SubQ |
| Twice daily (advanced) | 200 | — | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clean vial top with alcohol pad
- Add 2mL bacteriostatic water for convenient dosing
- Gently swirl - do not shake
- Solution should appear clear
- Label with date and concentration
- Store refrigerated immediately
- Use within 4-6 weeks
Tesamorelin/Ipamorelin Cycle
The Tesamorelin/Ipamorelin Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Improved sleep quality often noticed first; initial GH response
- Week 2-4
- Enhanced recovery; subtle body composition changes beginning
- Week 4-8
- Noticeable fat loss (especially visceral); improved energy
- Week 8-16
- Full body composition benefits; continued improvements
Dosing tools
Tesamorelin/Ipamorelin Blend Dosage Calculator
Calculate blended peptide doses with our visual syringe guide.
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
1 mL
2 mL
3 mL
5 mL
Custom
Custom Blend Compounds
Total: 10.0 mg
mg
mg
The dose of the anchor peptide you want per administration, in mcg or mg.
Conversion: 1,000 mcg = 1 mg
Results
Concentration
10.00
mg/mL
Doses per vial
20
Total blend to inject
0.50
mg
You'll get:
- Ipamorelin
- 250 mcgANCHOR
- Tesamorelin
- 250 mcg
1mL / 100 units
5 units
0.050 mL
Dosing Guidance
Recommended Schedule
Once daily (evening preferred) or twice daily for advanced protocols
Supply Duration
This vial provides 20 doses (20-day supply at 250 mcg daily)
Peptide Interactions
Research suggestions of Tesamorelin/Ipamorelin interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Different mechanisms; can complement for healing with GH support.
Weight
mk6
Growth
MK-677
MONITOR
Both affect GH release; combination may be excessive and affect glucose.
Weight
sem
Metabolic
Semaglutide
COMPATIBLE
Different pathways; some combine for body composition goals.
Side effects
Monitor: Be careful when combining Tesamorelin/Ipamorelin with MK-677.
Contraindications
Active malignancy (GH may promote tumor growth)
Diabetic retinopathy
Pregnancy or breastfeeding
Pituitary disorders
Hypersensitivity to components
Stop signs
Severe injection site reactions
Significant swelling or edema
Signs of glucose dysregulation
Severe joint pain
Allergic reactions
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
Tesamorelin/Ipamorelin Research References
Tesamorelin/Ipamorelin is a limited research compound
Tesamorelin/Ipamorelin
Tesamorelin/Ipamorelin is a limited research compound
Tesamorelin FDA Approval for HIV Lipodystrophy
Tesamorelin (Egrifta) approved for reduction of excess abdominal fat in HIV patients.
n.d.
Tesamorelin Effects on Visceral Fat
Tesamorelin significantly reduces visceral adipose tissue and improves lipid profiles.
n.d.
Ipamorelin Selectivity Profile
Ipamorelin selectively releases GH without affecting cortisol, prolactin, or ACTH.
n.d.
GHRH + GHRP Synergy
Combining GHRH and GHRP pathways produces synergistic GH release greater than either alone.
n.d.