Weight Loss Peptide Cheat Sheet

Survodutide is an experimental weekly injection being studied for weight loss. It works by curbing appetite and boosting the number of calories your body burns, and early studies show it also helps with a liver condition called MASH.

BAM-15 is an experimental compound that helps the body burn fat without raising body temperature, which makes it safer than similar older compounds. Most of what we know comes from animal studies, not humans.

Mazdutide is an experimental injection being studied for weight loss and blood sugar control in type 2 diabetes. It works by curbing appetite and helping your body burn more energy.

Cagrilintide mimics a natural hormone called amylin to help curb your appetite.

Hexarelin triggers a strong release of growth hormone, but the body gets used to it quickly, so its effects can fade with regular use. It's given as an injection under the skin.

This is Tirzepatide, a medication that activates two gut hormone pathways (GIP and GLP-1) to help with weight loss and blood sugar. Dosing starts at 2.5 mg once weekly for four weeks, then moves to 5 mg, and can rise in 2.5 mg steps every four weeks up to a maximum of 15 mg. Maintenance doses are 5, 10, or 15 mg weekly. Some people use very small 'microdoses' of 0.5 mg or less, or split the weekly dose into two injections, to reduce side effects. Splitting doses has shown to lower the peak blood level by roughly 28%, which is the usual explanation for less nausea.

Ipamorelin encourages your body to release its own growth hormone and tends to cause fewer side effects than similar peptides. It's usually injected at night on an empty stomach, since that's when the body's own growth hormone surge happens. Doses above 300 mcg don't produce proportionally more growth hormone, so 300 mcg per injection is the practical ceiling.

CJC-1295 with DAC is a long-acting peptide that keeps growth hormone levels steadily elevated over time.

GHRP-6 triggers the release of growth hormone and also tends to increase appetite.

Sermorelin encourages your body to release more of its own growth hormone. It's injected at night on an empty stomach, 30 to 60 minutes before bed, to line up with the body's natural overnight growth hormone release. Most protocols start at 200 to 300 mcg and increase by about 100 mcg every week or two.

This is a combination of Tesamorelin and Ipamorelin that helps reduce belly fat while boosting your body's natural growth hormone release. Taken once daily in the evening on an empty stomach, since food blunts the growth hormone pulse. Because the two peptides are blended in equal amounts, the dose is capped by Ipamorelin, which stops producing more growth hormone above 300 mcg.

Tesamorelin stimulates natural growth hormone release and is best known for reducing visceral (belly) fat and can improve overall metabolism. Injected before bed, at least two hours after the last meal.

This is Semaglutide, a long-acting medication that helps control appetite and blood sugar. Dosing starts at 0.25 mg once weekly and steps up every four weeks: 0.25 → 0.5 → 1 → 1.7 → 2.4 mg, with most people settling at 1.7 or 2.4 mg. It's also available as a ready-to-use pen that doesn't require mixing with water, and as a once-daily pill.

This is Retatrutide, an experimental medication that activates three different gut hormone pathways at once. Doses are raised slowly over time, a process called titration, with each step held for four weeks. In the Phase 3 TRIUMPH trials, everyone starts at 2 mg per week and steps up from there: 2 → 4 → 6 → 9 → 12 mg. Earlier trials found that starting at 2 mg rather than 4 mg caused fewer stomach side effects while producing the same weight loss at 48 weeks. Some people take much smaller 'microdoses,' often around 0.5 mg per week, to reduce side effects further. Going up gradually matters because most side effects, especially nausea and other stomach issues, appear right after a dose increase rather than at a steady dose.

5-Amino-1MQ supports mitochondrial function and can help with fat loss.

AOD-9604 is a small fragment of growth hormone that helps promote fat burning. It's injected in the morning on an empty stomach. It won't dissolve properly in plain bacteriostatic water and will cloud, flake, or gel at the bottom of the vial instead. Add a small amount of 0.6% acetic acid first and swirl until the solution turns clear, then top it up with bacteriostatic water, around 2 mL. If it has already gelled, adding the acid a few drops at a time will usually bring it back.

CJC-1295 and Ipamorelin work together to trigger a natural growth hormone pulse. Taken on an empty stomach before bed, with a break between cycles to keep the receptors responsive.

CJC-1295 without DAC is a shorter-acting peptide that triggers quick pulses of growth hormone release.

GHRP-2 triggers growth hormone release and causes less hunger than a similar peptide, GHRP-6.