Weight
GHRP-2
Growth
6
Amino acids
Molecular weight
Peptide
Type
GHRP-2 (Growth Hormone-Releasing Peptide-2), also known as pralmorelin, is a synthetic hexapeptide that potently stimulates pituitary release of growth hormone by binding to the ghrelin receptor (GHS-R1a). It was approved in Japan in 2004 by the PMDA as a diagnostic agent for growth hormone deficiency assessment and is the only GHRP to hold any national regulatory approval — it is not FDA-approved. In the research and biohacking communities it is used for body composition improvement, recovery, and anti-aging applications.
Top researched benefits
Overview of GHRP-2
GHRP-2 selectively binds to the growth hormone secretagogue receptor (GHS-R1a) in the pituitary gland and hypothalamus, triggering GH release via Ca2+ influx, protein kinase C, and cAMP-dependent pathways. It also binds CD36, activating cytoprotective PI-3K/AKT1 signaling that reduces oxidative stress and inflammation independent of the GH axis.
growth hormone enhancement
- Used as a diagnostic agent in Japan for assessing growth hormone deficiency in clinical settings.
- Stimulates endogenous growth hormone release through ghrelin receptor activation.
- Indirectly increases IGF-1 levels through enhanced GH secretion.
body composition
- Enhanced muscle protein synthesis through elevated growth hormone and IGF-1 levels.
- Improved lipolysis and body composition through GH-mediated fat oxidation.
- Faster recovery from exercise and improved sleep quality.
protective effects
- Myoprotective effects in muscle atrophy models through GHS-R1a stimulation.
- Cytoprotective effects observed in cardiac tissue research.
Typical Dose
100mcg starting dose per injection, titrating to 200–300mcg
Frequency
2–3 times daily, on an empty stomach
Cycle Duration
8 weeks on, 8 weeks off
Storage
Lyophilized: store below -20°C, stable at room temperature for up to 3 weeks. Reconstituted with bacteriostatic water: refrigerate at 2–8°C and use within 28 days. Avoid freeze-thaw cycles; aliquot if needed.
Chemical Makeup
Key benefits
Produces strong, pulsatile GH release from the pituitary by directly activating GHS-R1a, increasing peak GH levels more robustly than many other secretagogues
Promotes lean muscle mass accrual by elevating IGF-1 downstream of GH, supporting nitrogen retention and protein synthesis
Enhances lipolysis by shifting substrate utilization toward stored fat, improving body composition over extended cycles
Accelerates recovery from training and soft tissue injuries through GH-mediated upregulation of collagen synthesis and growth factors
Community interest
This peptide is still gaining traction in the community.
GH Secretagogue | Muscle Growth & Recovery
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoGHRP-2 Molecular Information
View the scientifc details of GHRP-2.
6
Amino Acids
GHRP-2
Ala
Ala
Position 1
?
?
Position 2
Ala
Ala
Position 3
Trp
Trp
Position 4
Phe
Phe
Position 5
Lys
Lys
Position 6
Molecular Weight
817.99DaChain Length
6Amino AcidsType
PeptideGHRP-2 Protocols
Subcutaneous injection is the primary and most effective route for GHRP-2, delivering precise GH-stimulating pulses with high bioavailability. Injections should be administered on an empty stomach — at least 2 hours post-meal — to prevent insulin from blunting GH release.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| GH Optimization / Anti-Aging | 100 | 2 day range | SubQ |
| Muscle Building | 200 | 3 day range | SubQ |
| Fat Loss | 150 | 2 day range | SubQ |
| Sleep Enhancement / Recovery | 200 | 1 day range | SubQ |
| GH Stimulation Cycle (with GHRH stack) | 100 | 3 day range | SubQ |
| Maintenance / Hormonal Support | 100 | 1 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Draw 2.5 mL of bacteriostatic water into an insulin syringe
- Insert the needle through the rubber stopper of the GHRP-2 vial at an angle and inject the BAC water slowly down the inner glass wall — never directly onto the lyophilized powder
- Do not shake the vial; gently swirl until the powder dissolves completely
- Cap the vial and store in the refrigerator at 2–8°C; use within 28 days
- Draw the desired dose volume into a fresh insulin syringe (e.g. 0.05 mL = 100 mcg at 2 mg/mL)
- Pinch a fold of skin at the injection site (abdomen, outer thigh, or upper arm), insert the needle at a 45–90 degree angle, and inject slowly
- Do not aspirate for subcutaneous injections; withdraw the needle at the same angle and apply gentle pressure
- Rotate injection sites at least 1 inch apart with each dose to prevent lipodystrophy
GHRP-2 Cycle
The GHRP-2 Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- GH spike within 15-30 minutes of injection
- Week 1-2
- Improved sleep quality and recovery
- Week 2-4
- Noticeable improvements in energy and well-being
- Week 4-8
- Visible changes in body composition and muscle fullness
- Week 8-12
- Full benefits realized with consistent use
Dosing tools
GHRP-2 Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
GHRP-2
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg GHRP-2 vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- GHRP-2
- Dosing
- 100mcg starting dose per injection, titrating to 200–300mcg
- Dosing Frequency
- 2–3 times daily, on an empty stomach
- Cycle Duration
- 8 weeks on, 8 weeks off
- Storage
- Lyophilized: store below -20°C, stable at room temperature for up to 3 weeks. Reconstituted with bacteriostatic water: refrigerate at 2–8°C and use within 28 days. Avoid freeze-thaw cycles; aliquot if needed.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of GHRP-2 interactions with other common peptides and substances.
Weight
ghrp
Growth
GHRP-6
COMPATIBLE
Similar mechanism; GHRP-2 is more potent with less appetite stimulation.
Weight
ipa
Growth
Ipamorelin
COMPATIBLE
Both are GHRPs; can be alternated but typically not stacked together.
Side effects
Contraindications
Active cancer or history of cancer
Pregnancy or breastfeeding
Pituitary disorders
Diabetic retinopathy
WADA prohibited for competitive athletes
Stop signs
Severe or persistent headaches
Unusual swelling in hands or feet
Signs of carpal tunnel syndrome
Allergic reactions
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
GHRP-2Research References
GHRP-2 is an approved compound
GHRP-2
GHRP-2 is an approved compound
Growth Hormone Releasing Peptide-2 increases food intake in healthy men
GHRP-2 infusion increased food intake by 35.9% compared to saline, demonstrating ghrelin-like orexigenic effects.
n.d.
Synthetic Growth Hormone-Releasing Peptides: Cytoprotective Effects
GHRPs including GHRP-2 demonstrated significant cytoprotective effects in cardiac and extracardiac tissues.
n.d.
GHRP-2 effects on growth hormone release in swine
Chronic GHRP-2 administration increased average daily gain by 22.35% and feed efficiency by 20.64%.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
