Sexual
HMG
Hormonal
0
Amino acids
Molecular weight
Peptide
Type
Human Menopausal Gonadotropin (hMG, menotropin) is a heterogeneous urinary-derived mixture extracted from postmenopausal women's urine, containing both FSH and LH glycoprotein activity in approximately a 1:1 ratio. It stimulates the gonads by directly activating FSH and LH receptors in the ovaries and testes, used clinically for ovulation induction, IVF ovarian stimulation, and treatment of hypogonadotropic hypogonadism. Female protocols typically run 7–12 days of daily injections; male spermatogenesis protocols require 3–6 months of treatment given three times weekly.
Top researched benefits
Overview of HMG
hMG's FSH component binds FSH receptors on granulosa cells (women) and Sertoli cells (men) to drive follicle maturation and spermatogenesis, while its LH component activates LH/hCG receptors on ovarian theca cells and testicular Leydig cells to support steroidogenesis and testosterone synthesis.
female fertility fdaapproved
- Stimulates follicular development in anovulatory women.
- Used in IVF protocols to stimulate multiple follicle development.
- Effective for inducing ovulation in polycystic ovary syndrome patients.
male fertility
- FSH promotes sperm production; LH stimulates testosterone for sperm development.
- Treats male infertility due to insufficient gonadotropin production.
testosterone support
- LH component stimulates testicular testosterone production.
Typical Dose
75–150 IU per injection
Frequency
once daily (women) or 3 times per week (men)
Cycle Duration
7–12 days for female ovulation induction; 3–6 months for male spermatogenesis protocols
Storage
Lyophilized: store at -20°C (stable at room temperature for up to 3 weeks). Reconstituted: refrigerate at 2–8°C and use within 2–7 days; for longer-term storage keep below -18°C. Avoid freeze-thaw cycles.
No visual available
Due to this peptide having no amino acids, there is no molecular chain to display.
Chemical Makeup
Key benefits
Induces ovulation in anovulatory women by directly stimulating follicle maturation via FSH receptor activation on granulosa cells
Enables controlled ovarian hyperstimulation for IVF, supporting retrieval of multiple mature oocytes per cycle
Restores spermatogenesis in men with hypogonadotropic hypogonadism, with approximately 75–80% of treated men showing improved sperm count and motility
Stimulates Leydig cell testosterone production via LH activity, simultaneously addressing androgen deficiency and infertility in hypogonadal men
Community interest
This peptide is still gaining traction in the community.
FSH/LH Gonadotropin Blend | Fertility & Hormonal Support
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoHMG Molecular Information
View the scientifc details of HMG.
Molecular Weight
23390.3DaChain Length
0Amino AcidsType
PeptideHMG Protocols
Subcutaneous or intramuscular injection is the primary clinical route for HMG, delivering both FSH and LH activity in a 1:1 ratio to stimulate folliculogenesis in women or spermatogenesis in men. For female ovarian stimulation, serial estradiol measurements and transvaginal ultrasound are required throughout the treatment cycle to monitor follicular response and detect early OHSS.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Stimulate spermatogenesis in men with secondary hypogonadism; HMG is co-administered with hCG 1500–5000 IU 2–3x/week as standard of care — standalone HMG monotherapy is not standard practice in this indication | 75 | 3 week range | SubQ or IM (combined with hCG) |
| Improve sperm concentration and motility in men who show insufficient response to the 75 IU HMG plus hCG combination after 12 or more weeks of treatment | 150 | 3 week range | SubQ or IM (combined with hCG) |
| Induce mono- or bi-follicular ovulation in anovulatory women with WHO Group I or II anovulation undergoing timed intercourse or intrauterine insemination | 150 | 1 day range | SubQ or IM |
| Achieve multifollicular development sufficient for oocyte retrieval in IVF cycles conducted without GnRH agonist pituitary downregulation | 225 | 1 day range | SubQ or IM |
| Overcome pituitary suppression from GnRH agonist downregulation while achieving adequate multifollicular recruitment for oocyte retrieval in IVF | 225 | 1 day range | SubQ or IM |
| Minimise OHSS risk in women with elevated AMH or polycystic ovary morphology while achieving a controlled cohort of mature follicles for safe oocyte retrieval | 112.5 | 1 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Draw 3.0 mL of bacteriostatic water (BAC water) into a sterile 3 mL syringe using a 22–23 gauge drawing needle
- Insert the needle into the HMG vial at an angle and inject the BAC water slowly down the inside wall of the vial — do not aim directly onto the powder
- Gently swirl the vial in a circular motion until the powder is fully dissolved — do not shake, as shaking degrades the FSH and LH glycoprotein components
- Inspect the reconstituted solution: it should be clear and colourless; discard if cloudy or contains particles
- Label the vial with the date and time of reconstitution and refrigerate at 2–8 °C; use within a few days
- For each injection, draw the required dose volume using a fresh syringe; each 75 IU dose equals 3.0 mL at 25 IU/mL — consider splitting into multiple 1 mL injections at separate sites if volume is problematic
- Choose an injection site (abdomen preferred for SubQ; upper outer thigh or gluteal muscle for IM), wipe with an alcohol swab and allow to dry completely
- Pinch the skin, insert the needle at 90° for SubQ into fatty tissue, or at 90° into the muscle for IM, inject slowly, then withdraw and apply gentle pressure
- Rotate injection sites at least 1 inch apart with each administration
- Use a new sterile syringe and needle for each injection; discard used sharps in a sharps container immediately after use
HMG Cycle
The HMG Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- Follicular recruitment begins
- Day 4-7
- Follicular growth continues; monitoring required
- Day 8-12
- Follicles reach mature size; trigger ovulation
- Week 0-0
- Ovulation occurs ~36 hours after hCG trigger
Dosing tools
HMG Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
HMG
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg HMG vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- HMG
- Dosing
- 75–150 IU per injection
- Dosing Frequency
- once daily (women) or 3 times per week (men)
- Cycle Duration
- 7–12 days for female ovulation induction; 3–6 months for male spermatogenesis protocols
- Storage
- Lyophilized: store at -20°C (stable at room temperature for up to 3 weeks). Reconstituted: refrigerate at 2–8°C and use within 2–7 days; for longer-term storage keep below -18°C. Avoid freeze-thaw cycles.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of HMG interactions with other common peptides and substances.
Sexual
gon
Hormonal
Gonadorelin
COMPATIBLE
Different mechanisms; may be used in different fertility protocols.
Side effects
Contraindications
Primary ovarian failure
Uncontrolled thyroid or adrenal dysfunction
Sex hormone-dependent tumors
Abnormal uterine bleeding of unknown cause
Ovarian cysts (not due to PCOS)
Pregnancy
Stop signs
Severe abdominal pain or bloating
Rapid weight gain
Difficulty breathing
Nausea and vomiting
Decreased urination
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
HMGResearch References
HMG is a fda approved compound
HMG
HMG is a fda approved compound
Human Menopausal Gonadotropin
HMG contains FSH and LH in 1:1 ratio extracted from postmenopausal urine.
n.d.
HMG vs Recombinant FSH in PCOS Patients Undergoing IVF
No significant differences in pregnancy rates between FSH alone, rFSH+HMG, and rFSH+rLH groups.
n.d.
Effect of HMG and HP-FSH on IVF Outcomes
Beneficial effects of HMG on fertilization rates and pre-embryo development compared to HP-FSH.
n.d.
Generic hMG vs Costly FSH for Ovulation Induction
Generic hMG products do not adversely affect pregnancy rates and are appropriate cost-effective alternatives.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
