Sexual
HMG
Hormonal
0
Amino acids
Molecular weight
Peptide
Type
Human Menopausal Gonadotropin (HMG) is a hormonally active medication containing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in a 1:1 ratio, extracted from the urine of postmenopausal women. FDA-approved for fertility treatment, HMG stimulates ovarian follicle development in women and spermatogenesis in men. While largely replaced by recombinant gonadotropins in some settings, HMG remains an effective and cost-efficient option for ovulation induction and assisted reproduction.
Top researched benefits
Overview of HMG
HMG acts on gonadal tissue through two mechanisms: FSH stimulates growth and maturation of ovarian follicles containing eggs in women, and promotes spermatogenesis in men. LH stimulates ovulation and corpus luteum formation in women, and Leydig cells in men to produce testosterone. Highly purified HMG (HP-hMG) has enhanced FSH receptor activity with reduced inactive proteins. The LH component modifies follicular development and decreases intermediate-sized follicles, potentially resulting in safer, more controlled stimulation.
female fertility fdaapproved
- Stimulates follicular development in anovulatory women.
- Used in IVF protocols to stimulate multiple follicle development.
- Effective for inducing ovulation in polycystic ovary syndrome patients.
male fertility
- FSH promotes sperm production; LH stimulates testosterone for sperm development.
- Treats male infertility due to insufficient gonadotropin production.
testosterone support
- LH component stimulates testicular testosterone production.
Typical Dose
75-150 IU for ovulation induction; 150-300 IU for IVF
Frequency
Daily during stimulation phase (7-12 days)
Cycle Duration
7-12 days per cycle
Storage
Lyophilized: Room temperature. Reconstituted: 2-8°C, use immediately after reconstitution
No visual available
Due to this peptide having no amino acids, there is no molecular chain to display.
Chemical Makeup
Key benefits
FDA-approved for fertility treatment
Stimulates ovarian follicle development
Contains both FSH and LH naturally
Promotes spermatogenesis in men
Cost-effective alternative to recombinant FSH
LH activity may improve fertilization rates
Long clinical track record
Lower OHSS incidence with HP-hMG
Community interest
This peptide is still gaining traction in the community.
Human Menopausal Gonadotropin | FSH/LH Fertility Hormone
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoHMG Protocols
HMG is administered via intramuscular or subcutaneous injection. Treatment typically starts on day 2-3 of the menstrual cycle and continues for 7-12 days with monitoring. Dosing is individualized based on follicular response monitored by ultrasound and estradiol levels.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Ovulation induction | 75 | 1 week range | IM or SubQ |
| IVF stimulation | 150 | 7 week range | IM or SubQ |
| Male fertility | 75 | 2 week range | IM or SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Add provided diluent to powder vial
- Gently swirl until dissolved
- Draw prescribed dose into syringe
- Inject intramuscularly or subcutaneously
- Use immediately after reconstitution
HMG Cycle
The HMG Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- Follicular recruitment begins
- Day 4-7
- Follicular growth continues; monitoring required
- Day 8-12
- Follicles reach mature size; trigger ovulation
- Week 0-0
- Ovulation occurs ~36 hours after hCG trigger
Dosing tools
HMG Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
HMG
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg HMG vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- HMG
- Dosing
- 75-150 IU for ovulation induction; 150-300 IU for IVF
- Dosing Frequency
- Daily during stimulation phase (7-12 days)
- Cycle Duration
- 7-12 days per cycle
- Storage
- Lyophilized: Room temperature. Reconstituted: 2-8°C, use immediately after reconstitution
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of HMG interactions with other common peptides and substances.
Sexual
gon
Hormonal
Gonadorelin
COMPATIBLE
Different mechanisms; may be used in different fertility protocols.
Side effects
Contraindications
Primary ovarian failure
Uncontrolled thyroid or adrenal dysfunction
Sex hormone-dependent tumors
Abnormal uterine bleeding of unknown cause
Ovarian cysts (not due to PCOS)
Pregnancy
Stop signs
Severe abdominal pain or bloating
Rapid weight gain
Difficulty breathing
Nausea and vomiting
Decreased urination
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
HMGResearch References
HMG is an extensively studied compound
HMG
HMG is an extensively studied compound
Human Menopausal Gonadotropin
HMG contains FSH and LH in 1:1 ratio extracted from postmenopausal urine.
n.d.
HMG vs Recombinant FSH in PCOS Patients Undergoing IVF
No significant differences in pregnancy rates between FSH alone, rFSH+HMG, and rFSH+rLH groups.
n.d.
Effect of HMG and HP-FSH on IVF Outcomes
Beneficial effects of HMG on fertilization rates and pre-embryo development compared to HP-FSH.
n.d.
Generic hMG vs Costly FSH for Ovulation Induction
Generic hMG products do not adversely affect pregnancy rates and are appropriate cost-effective alternatives.
n.d.