CJC-1295 (No Dac)/Ipamorelin
GHRH + Ghrelin Agonist Blend | GH Pulse Amplification & Body Composition
Learn moreWeight
CJC-1295 (No Dac)/Ipamorelin
Growth
2
Amino acids
Molecular weight
Blend
Type
CJC-1295 (No DAC)/Ipamorelin is a two-peptide blend combining a GHRH analog (CJC-1295 No DAC, ~3367.95 Da) with a selective ghrelin receptor agonist (Ipamorelin, ~711.85 Da) to amplify endogenous growth hormone release via complementary mechanisms. CJC-1295 (No DAC) binds GHRH receptors to extend each GH pulse, while Ipamorelin triggers a rapid, selective GH pulse through GHSR-1a without raising cortisol or prolactin. The combination has been explored in off-label human use contexts for muscle preservation, fat loss, sleep quality, and recovery, with the GHRH component having reached Phase 2 clinical investigation.
Top researched benefits
Overview of CJC-1295 (No Dac)/Ipamorelin
CJC-1295 (No DAC) is a modified GHRH analog that binds GHRH receptors on pituitary somatotroph cells to stimulate sustained GH synthesis and secretion. Ipamorelin is a pentapeptide ghrelin receptor (GHSR-1a) agonist that triggers rapid, pulsatile GH release selectively without activating ACTH or cortisol pathways; together the two compounds produce synergistic, physiologic GH pulses that are 3–5 fold greater than either agent alone.
muscle growth
- Growth hormone elevation supports muscle protein synthesis and nitrogen retention during training.
- Sustained GH patterns may accelerate muscle repair between exercise sessions.
- GH optimization helps maintain muscle during caloric restriction or aging.
metabolic health
- Growth hormone promotes lipolysis while supporting lean tissue maintenance.
- Enhanced GH patterns may improve glucose and fat utilization.
antiaging
- Evening GH peaks align with deeper, more restorative sleep patterns.
- Sustained GH elevation supports skin elasticity and connective tissue health.
recovery
- Growth hormone supports tissue repair and recovery from exercise or injury.
- Enhanced collagen synthesis supports joint and connective tissue integrity.
Typical Dose
300mcg CJC-1295 No DAC + 300mcg Ipamorelin per injection (each peptide dosed separately)
Frequency
once daily (before bed or upon waking)
Cycle Duration
12 weeks on, 4 weeks off
Storage
Lyophilized: store at -20°C for up to 24–36 months. Reconstituted with bacteriostatic water: refrigerate at 2–8°C, use within 28 days. Do not freeze reconstituted solution.
Chemical Makeup
Key benefits
Increases endogenous GH and IGF-1 levels in a pulsatile, physiologic pattern, supporting muscle protein synthesis and nitrogen retention
Accelerates lipolysis and visceral fat reduction while preserving lean muscle mass through IGF-1-mediated metabolic signaling
Improves sleep architecture — particularly slow-wave sleep — enhancing overnight recovery and endogenous GH production during the nocturnal pulse
Supports tendon, ligament, and connective tissue repair via IGF-1-mediated upregulation of collagen synthesis at injury sites
Community interest
This peptide is still gaining traction in the community.
GHRH + Ghrelin Agonist Blend | GH Pulse Amplification & Body Composition
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoCJC-1295 (No Dac)/Ipamorelin Molecular Information
View the scientifc details of CJC-1295 (No Dac)/Ipamorelin.
2
Amino Acids
CJC-1295 (No Dac)/Ipamorelin
Asn
Asn
Position 1
Ala
Ala
Position 2
Molecular Weight
3367.95DaChain Length
2Amino AcidsType
BlendCJC-1295 (No Dac)/Ipamorelin Protocols
Subcutaneous injection is the preferred route for CJC-1295 (No DAC)/Ipamorelin because it delivers both peptides directly into systemic circulation without mucosal or gastrointestinal degradation, enabling the synergistic GHRH (CJC-1295) and ghrelin-mimetic GHRP (Ipamorelin) mechanisms to act simultaneously on pituitary somatotrophs. Injections are administered into abdominal subcutaneous fat at least 2 hours after the last meal, typically before bed, to coincide with the natural nocturnal GH pulse and avoid insulin-mediated blunting of GH release.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Beginner / Tolerance assessment | 100 | 1 day range | SubQ |
| General health and sleep quality | 200 | 1 day range | SubQ |
| Fat loss and body composition | 200 | 1 day range | SubQ |
| Lean muscle gain | 250 | 1 day range | SubQ |
| Anti-aging and longevity | 150 | 1 day range | SubQ |
| Advanced performance and recovery | 300 | 2 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Remove the lyophilized vial and bacteriostatic water (BAC water) vial from refrigerator storage and allow both to reach room temperature for 10–15 minutes
- Wipe the rubber stoppers of both vials with a fresh alcohol swab and allow to dry for 30 seconds
- Draw 3.0 mL of bacteriostatic water into a 3 mL syringe
- Insert the needle into the peptide vial and inject the BAC water slowly down the inside wall of the vial — never aim the stream directly at the lyophilized powder
- Gently swirl or roll the vial between your palms until the powder is fully dissolved — do not shake or vortex the vial
- Visually inspect the solution — it should be clear and colorless with no visible particulates
- Label the vial with the date of reconstitution and store upright in the refrigerator at 2–8°C (35.6–46.4°F), protected from light
- To inject: clean the injection site (abdomen, at least 2 inches from the navel) with an alcohol swab and allow to dry
- Draw the prescribed dose into an insulin syringe, insert the needle at a 45-degree angle into a pinched fold of subcutaneous abdominal skin
- Inject slowly and steadily, withdraw the needle, apply light pressure — do not rub
- Rotate injection sites systematically between the left abdomen, right abdomen, thighs, and upper arms to minimize site irritation
- Dispose of used syringes immediately in a sharps container
CJC-1295 (No Dac)/Ipamorelin Cycle
The CJC-1295 (No Dac)/Ipamorelin Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Improved sleep depth and quality; increased dream vividness
- Week 3-4
- Enhanced exercise recovery; reduced muscle soreness; improved energy
- Week 6-8
- Gradual body composition changes; improved skin quality; general well-being
- Week 8-12
- Optimized benefits plateau; individual responses vary significantly
- Week 0-0
- Benefits persist several weeks due to improved sleep and recovery patterns
Dosing tools
CJC-1295 (No Dac)/IpamorelinBlend Dosage Calculator
Calculate blended peptide doses with our visual syringe guide.
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
1 mL
2 mL
3 mL
5 mL
Custom
Blend Composition
Total: 2.0 mg
mg
The compound you want to dose by. Results will be calculated based on this compound.
The dose of the anchor compound you want per administration, in mcg or mg.
Conversion: 1,000 mcg = 1 mg
Results
Concentration
2.00
mg/mL
Doses per vial
8
Total blend to inject
0.25
mg
You'll get:
- Ipamorelin
- 250 mcgANCHOR
1mL / 100 units
12 units
0.125 mL
Dosing Guidance
Recommended Schedule
once daily (before bed or upon waking)
Supply Duration
This vial provides 8 doses (8-day supply at 250 mcg daily)
Peptide Interactions
Research suggestions of CJC-1295 (No Dac)/Ipamorelin interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
No known interactions; different mechanisms (GH optimization vs. tissue repair signaling).
Weight
mk6
Growth
MK-677
MONITOR
Both affect GH pathways; monitor for excessive GH elevation and insulin sensitivity changes.
Side effects
Monitor: Be careful when combining CJC-1295 (No Dac)/Ipamorelin with MK-677.
Contraindications
Cancer history or active malignancy
Severe diabetes requiring tight glucose control
Carpal tunnel syndrome or nerve compression disorders
Stop signs
Persistent joint pain or swelling indicating fluid retention
Significant blood glucose changes or diabetic control issues
Unusual fatigue, lethargy, or mood deterioration
Injection site infections or persistent reactions
Numbness or tingling in hands/feet
Signs of accelerated tumor growth if cancer history exists
Bad signs
Comments
0.0
0 reviews
5
4
3
2
1
No comments yet
Be the first to share your experience. Your review helps others make more informed decisions.
Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
CJC-1295 (No Dac)/IpamorelinResearch References
CJC-1295 (No Dac)/Ipamorelin is an experimental compound
CJC-1295 (No Dac)/Ipamorelin
CJC-1295 (No Dac)/Ipamorelin is an experimental compound
CJC-1295 Clinical Efficacy - Teichman et al.
2-10 fold GH increase, 1.5-3 fold IGF-1 increase with 5.8-8.1 day half-life.
2006
Ipamorelin Selectivity - Raun et al.
First selective GHS with no ACTH/cortisol effects even at 200x effective dose.
1998
GH Pulsatility Preservation - Ionescu & Frohman
CJC-1295 preserves pulsatile GH secretion while increasing basal levels 7.5-fold.
2006
GHRH-GHS Receptor Interaction - Cunha & Mayo
Cellular study demonstrating potentiation of GHRH signaling with GHS receptors present.
2002
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
