Adipotide
FDA APPROVAL PENDING
Phase 1
Weight
Adipotide
25
Amino acids
Molecular weight
Peptide
Type
Adipotide (also known as FTPP or Prohibitin-Targeting Peptide-1) is a bipartite peptidomimetic that selectively destroys the blood vessels supplying white adipose tissue, causing fat cell death through ischemia-induced apoptosis. It targets prohibitin and annexin A2 receptors expressed on white adipose vasculature, distinguishing it from hormonal or metabolic weight-loss agents. It has been studied in obese rodent and primate models with dramatic fat-loss results, and entered Phase 1 clinical trials in 2012, though development was subsequently discontinued due to renal toxicity concerns.
Top researched benefits
Overview of Adipotide
Adipotide's homing sequence (CKGGRAKDC) binds to prohibitin and annexin A2 receptors on endothelial cells of white adipose tissue vasculature, after which its proapoptotic D(KLAKLAK)2 domain disrupts mitochondrial membranes, triggering targeted apoptosis of the feeding vasculature and causing ischemic death of downstream white adipocytes.
weight loss
- Selective white adipose tissue vascular targeting produced 7-15% body-weight loss over 4 weeks in obese macaques.
metabolic
- Improved insulin response (reduced insulin AUC) following fat-mass reduction in primates.
appetite control
- Weight loss without primary appetite suppression; peripheral vascular approach.
Typical Dose
250–1000mcg per injection, titrated up over cycle
Frequency
once daily subcutaneous injection
Cycle Duration
4–8 week cycle with gradual dose escalation
Storage
Lyophilized: -20°C long-term (up to 2 years) or 2–8°C short-term (up to 3 months). Reconstituted: refrigerate at 2–8°C, use within 14 days, avoid freeze-thaw cycles.
Chemical Makeup
Key benefits
Selective destruction of white adipose tissue vasculature leading to targeted fat cell apoptosis without affecting lean tissue
Produced approximately 11% body weight reduction in obese rhesus monkeys after 28 days of treatment
Caused up to 30% body weight reduction in obese rodent models over a 4-week treatment period
Significantly improved insulin sensitivity and reduced insulinogenic index in obese primate models within days of treatment onset
Community interest
This peptide is still gaining traction in the community.
Proapoptotic Peptidomimetic | Targeted Fat Loss
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoAdipotide Molecular Information
View the scientifc details of Adipotide.
25
Amino Acids
Adipotide
Cys
Cys
Position 1
Lys
Lys
Position 2
Gly
Gly
Position 3
Gly
Gly
Position 4
Arg
Arg
Position 5
Ala
Ala
Position 6
Lys
Lys
Position 7
Asp
Asp
Position 8
Cys
Cys
Position 9
Gly
Gly
Position 10
Gly
Gly
Position 11
Lys
Lys
Position 12
Leu
Leu
Position 13
Ala
Ala
Position 14
Lys
Lys
Position 15
Leu
Leu
Position 16
Ala
Ala
Position 17
Lys
Lys
Position 18
Lys
Lys
Position 19
Leu
Leu
Position 20
Ala
Ala
Position 21
Lys
Lys
Position 22
Leu
Leu
Position 23
Ala
Ala
Position 24
Lys
Lys
Position 25
Molecular Weight
2611.41DaChain Length
25Amino AcidsType
PeptideAdipotide Protocols
Subcutaneous injection is the primary and only research-validated delivery route for Adipotide (FTPP), used in all primate and rodent preclinical fat-loss studies. Injections are administered once daily into abdominal subcutaneous fat, targeting prohibitin receptors on white adipose vasculature; adequate daily hydration is essential throughout any cycle to support renal clearance and reduce nephrotoxicity risk.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Fat loss — conservative titration start | 250 | 1 day range | SubQ |
| Fat loss — moderate titration | 500 | 1 day range | SubQ |
| Fat loss — advanced titration | 750 | 1 day range | SubQ |
| Fat loss — peak flat dose | 1000 | 1 day range | SubQ |
| Fat loss — primate standard dose (0.25 mg/kg, reference 80 kg body weight) | 20000 | 1 day range | SubQ |
| Fat loss — primate advanced dose (0.43 mg/kg, reference 80 kg body weight) | 34400 | 1 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Allow the lyophilized Adipotide vial to reach room temperature before reconstitution (approximately 15–20 minutes out of the freezer)
- Draw 3.0 mL of bacteriostatic water (BAC water) into a sterile drawing syringe
- Insert the drawing needle through the vial stopper and inject the BAC water slowly down the inside wall of the vial — do not aim the stream directly onto the powder
- Gently swirl or roll the vial between your palms until the powder is fully dissolved — do not shake the vial, as shaking can degrade the peptide
- Label the vial with the reconstitution date; refrigerate at 2–8 °C upright and use within 14 days
- Calculate your dose volume: a 10 mg vial reconstituted with 3.0 mL yields a concentration of 3.33 mg/mL (3,333 mcg/mL)
- Draw the calculated dose into an insulin syringe, tap to raise air bubbles, and gently depress the plunger to expel them
- Clean the injection site (abdomen 2 inches from the navel preferred) with an alcohol swab and allow the skin to dry fully
- Pinch the skin to raise a fold, insert the needle at a 45-degree angle into the subcutaneous fat layer, and inject slowly and steadily without aspirating
- Withdraw the needle smoothly and apply gentle pressure with a clean swab — do not rub the site
- Rotate injection sites systematically across the abdomen, thighs, and upper arms every 3–4 injections to prevent local tissue damage
Adipotide Cycle
The Adipotide Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Early reduction in abdominal circumference
- Week 2-4
- Progressive weight/fat-mass decline
- Week 0-0
- Partial rebound possible; lab signals include mild creatinine rise and electrolyte shifts
Dosing tools
Adipotide Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Adipotide
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Adipotide vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Adipotide
- Dosing
- 250–1000mcg per injection, titrated up over cycle
- Dosing Frequency
- once daily subcutaneous injection
- Cycle Duration
- 4–8 week cycle with gradual dose escalation
- Storage
- Lyophilized: -20°C long-term (up to 2 years) or 2–8°C short-term (up to 3 months). Reconstituted: refrigerate at 2–8°C, use within 14 days, avoid freeze-thaw cycles.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Adipotide interactions with other common peptides and substances.
Weight
aod
Metabolic
AOD-9604
MONITOR
No published data on combined use or pharmacodynamic interaction.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
No known direct interaction; distinct mechanisms and targets.
Weight
cag
Metabolic
Cagrilintide
MONITOR
No clinical data on co-administration; mechanisms differ.
Skin
mela
Sexual
Melanotan II
MONITOR
Theoretical vascular/pressor effects; stagger dosing, monitor BP and hydration.
Weight
GLP-1
Metabolic
GLP-1
MONITOR
Potential additive dehydration/GI effects; monitor renal function.
Side effects
Monitor: Be careful when combining Adipotide with AOD-9604, Cagrilintide, Melanotan II, GLP-1.
Contraindications
Pregnancy/lactation (not studied)
Dehydration
Concurrent nephrotoxic medications
Stop signs
Sustained creatinine elevation or oliguria
Progressive electrolyte abnormalities
Severe injection-site reactions or systemic symptoms
Unexpected toxicity
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
AdipotideResearch References
Adipotide is a phase 1 compound
Adipotide
Adipotide is a phase 1 compound
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys
Rhesus macaques at 0.43 mg/kg SC daily for 28 days showed 7.4-14.7% weight loss; insulin resistance improved; mild, dose-dependent, reversible proximal tubule changes.
2011
Reversal of obesity by targeted ablation of adipose tissue
Mice with diet-induced obesity showed ~30% weight reduction; adipose vascular apoptosis; metabolic normalization.
2004
Prohibitin/Annexin A2 Interaction Regulates Fatty-Acid Transport
Mechanistic validation of prohibitin/ANXA2 axis in adipose tissue, core to TP01 targeting.
2016
Mixed-Chirality Prohibitin Peptide: D-(RLARLAR)2 Enhances Stability
Next-generation prohibitin constructs improve serum stability and efficacy vs. first-generation TP01.
2025
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
