Adipotide
FDA APPROVAL PENDING
Emerging
Weight
Adipotide
25
Amino acids
Molecular weight
Peptide
Type
Chimeric adipose-vasculature-targeted peptidomimetic targeting prohibitin/annexin A2 on white adipose tissue endothelium, delivering pro-apoptotic D-(KLAKLAK)2 motif. In obese primates it produced rapid fat loss with improved insulin resistance, yet development halted after Phase 1 due to kidney safety signals.
Top researched benefits
Overview of Adipotide
CKGGRAKDC ligand homes to prohibitin/annexin A2 on white-fat endothelium; linked D-(KLAKLAK)2 disrupts mitochondrial membranes post-internalization, triggering localized endothelial apoptosis and adipocyte loss.
Weight Loss
- Selective white adipose tissue vascular targeting produced 7-15% body-weight loss over 4 weeks in obese macaques.
Metabolic
- Improved insulin response (reduced insulin AUC) following fat-mass reduction in primates.
Appetite Control
- Weight loss without primary appetite suppression; peripheral vascular approach.
Storage
Lyophilized: -20°C freezer. Reconstituted: 2-8°C refrigerated
Frequency
Once daily
Typical Dose
0.43 mg/kg
Cycle Duration
28 days
Chemical Makeup
Key benefits
Rapid fat-mass reduction via selective white adipose tissue vascular targeting
Improved insulin sensitivity following adipose reduction
Non-CNS peripheral mechanism distinct from appetite suppressants
Community interest
This peptide is still gaining traction in the community.
Prohibitin-Targeting Peptidomimetic | Experimental Anti-Obesity
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesAdipotide Molecular Information
View the scientifc details of Adipotide.
25
Amino Acids
Adipotide
Cys
Cys
Position 1
Lys
Lys
Position 2
Gly
Gly
Position 3
Gly
Gly
Position 4
Arg
Arg
Position 5
Ala
Ala
Position 6
Lys
Lys
Position 7
Asp
Asp
Position 8
Cys
Cys
Position 9
Gly
Gly
Position 10
Gly
Gly
Position 11
Lys
Lys
Position 12
Leu
Leu
Position 13
Ala
Ala
Position 14
Lys
Lys
Position 15
Leu
Leu
Position 16
Ala
Ala
Position 17
Lys
Lys
Position 18
Lys
Lys
Position 19
Leu
Leu
Position 20
Ala
Ala
Position 21
Lys
Lys
Position 22
Leu
Leu
Position 23
Ala
Ala
Position 24
Lys
Lys
Position 25
Molecular Weight
2557.2DaChain Length
25Amino AcidsType
PeptideAdipotide Protocols
Rapid fat-mass reduction in obese non-human primates with improved insulin sensitivity; direct white adipose tissue vascular targeting.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Primate Research Replication | 0.43 | 1 week range | SubQ |
| Dose-Finding (Research) | 0.1 | 1 week range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Sanitize hands and workspace; swab vial septum
- Inject BAC water slowly down vial wall; do not jet onto powder
- Gently swirl until fully dissolved (do not shake)
- Label with concentration/date; store at 2-8°C
Adipotide Cycle
The Adipotide Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Early reduction in abdominal circumference
- Week 2-4
- Progressive weight/fat-mass decline
- Week 0-0
- Partial rebound possible; lab signals include mild creatinine rise and electrolyte shifts
Dosing tools
Adipotide Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
Adipotide
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Adipotide vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- Adipotide
- Dosing
- 0.43 mg/kg
- Dosing Frequency
- Once daily
- Cycle Duration
- 28 days
- Storage
- Lyophilized: -20°C freezer. Reconstituted: 2-8°C refrigerated
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Adipotide interactions with other common peptides and substances.
Weight
aod
Metabolic
AOD-9604
MONITOR
No published data on combined use or pharmacodynamic interaction.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
No known direct interaction; distinct mechanisms and targets.
Weight
cag
Metabolic
Cagrilintide
MONITOR
No clinical data on co-administration; mechanisms differ.
Skin
mela
Sexual
Melanotan II
MONITOR
Theoretical vascular/pressor effects; stagger dosing, monitor BP and hydration.
Weight
sem
Metabolic
Semaglutide
MONITOR
Potential additive dehydration/GI effects; monitor renal function.
Weight
tir
Metabolic
Tirzepatide
MONITOR
Overlapping weight-loss effects; monitor kidney function, volume status, electrolytes.
Side effects
Monitor: Be careful when combining Adipotide with AOD-9604, Cagrilintide, Melanotan II, Semaglutide, Tirzepatide.
Contraindications
Pregnancy/lactation (not studied)
Dehydration
Concurrent nephrotoxic medications
Stop signs
Sustained creatinine elevation or oliguria
Progressive electrolyte abnormalities
Severe injection-site reactions or systemic symptoms
Unexpected toxicity
Bad signs
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Frequently asked questions
What benefits can peptides offer in research?
Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.
What are some exciting applications of peptides in modern science?
Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.
How do peptides influence health and wellness?
Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.
Where can I find the latest studies on peptide applications?
Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.
Are there any guidelines for using peptides in research?
Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.
What is the difference between peptides and proteins?
Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.
How should peptides be stored?
Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.
Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
AdipotideResearch References
Adipotide is an emerging compound
Adipotide
Adipotide is an emerging compound
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys
Rhesus macaques at 0.43 mg/kg SC daily for 28 days showed 7.4-14.7% weight loss; insulin resistance improved; mild, dose-dependent, reversible proximal tubule changes.
2011
Reversal of obesity by targeted ablation of adipose tissue
Mice with diet-induced obesity showed ~30% weight reduction; adipose vascular apoptosis; metabolic normalization.
2004
Prohibitin/Annexin A2 Interaction Regulates Fatty-Acid Transport
Mechanistic validation of prohibitin/ANXA2 axis in adipose tissue, core to TP01 targeting.
2016
Mixed-Chirality Prohibitin Peptide: D-(RLARLAR)2 Enhances Stability
Next-generation prohibitin constructs improve serum stability and efficacy vs. first-generation TP01.
2025