Cognitive
Pinealon
Longevity
3
Amino acids
Molecular weight
Peptide
Type
Developed in Russia, Pinealon demonstrates unique DNA-interaction for neuroprotection and cognitive enhancement. Benefits traumatic brain injury recovery and age-related cognitive decline with excellent safety profile.
Top researched benefits
Overview of Pinealon
Penetrates nuclear membranes to directly interact with DNA, modulates gene expression via histone H1.3 binding and MAPK/ERK pathway activation.
neuroprotection
- Clinical protocol of 5mg daily showed significant cognitive improvements in 72-patient study.
- Subcutaneous administration allows systemic circulation to brain tissue for neuroprotective effects.
- Caspase-3 suppression, ROS reduction, and excitotoxicity protection.
cognitive
- Enhanced neurotransmitter function with 1.9x serotonin increase in cell cultures.
- 100 ng/kg optimal dose improved spatial learning in hippocampus.
antiaging
- Irisin expression increases linked to telomere protection and mitochondrial enhancement.
- 32-patient study showed significant improvements in aging indicators over 20-30 days.
Typical Dose
Injectable: 5mg daily or 100-300mcg daily; Oral: 0.2mg twice daily
Frequency
Injectable: daily for 20 days; Oral: morning and afternoon on empty stomach
Cycle Duration
20 days per cycle
Storage
Refrigerate at 2-8°C, use within 30 days after reconstitution
Chemical Makeup
Key benefits
Direct DNA interaction
Neuroprotection
Cognitive enhancement
Excellent safety profile
40+ years of clinical use in Russia
Community interest
This peptide is still gaining traction in the community.
Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoPinealon Molecular Information
View the scientifc details of Pinealon.
3
Amino Acids
Pinealon
Glu
Glu
Position 1
Asp
Asp
Position 2
Arg
Arg
Position 3
Molecular Weight
418.4DaChain Length
3Amino AcidsType
PeptidePinealon Protocols
Highest bioavailability, direct systemic delivery, established clinical protocols.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Neuroprotection | 5 | 1 week range | SubQ |
| Cognitive Enhancement | 100 | 1 week range | SubQ |
| Anti-aging | 5 | 20 week range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Remove powder and water from refrigeration
- Clean vial tops with alcohol swabs; allow to dry
- Draw bacteriostatic water into syringe
- Inject water slowly down vial side to avoid foam
- Gently swirl until completely dissolved
- Store at 2-8°C
- Use within 30 days
Pinealon Cycle
The Pinealon Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Improved mental clarity and focus
- Week 2-3
- Enhanced cognitive processing and memory
- Week 3-4
- Peak neuroprotective and anti-aging benefits
Dosing tools
Pinealon Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Pinealon
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Pinealon vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Pinealon
- Dosing
- Injectable: 5mg daily or 100-300mcg daily; Oral: 0.2mg twice daily
- Dosing Frequency
- Injectable: daily for 20 days; Oral: morning and afternoon on empty stomach
- Cycle Duration
- 20 days per cycle
- Storage
- Refrigerate at 2-8°C, use within 30 days after reconstitution
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Pinealon interactions with other common peptides and substances.
Longevity
epi
Immunity
Epitalon
SYNERGISTIC
Enhanced neuroprotection through complementary telomerase activation pathways.
Longevity
thy
Immunity
Thymalin
COMPATIBLE
Safe combination supporting neural-immune axis optimization.
Side effects
Contraindications
Pregnancy
Lactation
Stop signs
Severe headaches or mood changes
Persistent injection site reactions
Signs of infection at injection site
Unusual neurological symptoms
Allergic reactions
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
PinealonResearch References
Pinealon is a well studied compound
Pinealon
Pinealon is a well studied compound
Human Clinical Trial - Post-Traumatic Cerebrasthenia
72 patients aged 30-74; 0.2mg twice daily; 20-30 days. Improved memory, reduced headache severity, and enhanced emotional stability compared to controls.
2015
Aging Study - Polymorbidity Patients
32 patients aged 41-83; variable dosing; 30 days. Significant improvements in biological aging biomarkers with anabolic effects.
2015
Diabetic Rat Model - Spatial Learning
100 ng/kg optimal dose; 14 days. Enhanced NMDA receptor expression in hippocampus with neuroplasticity improvements.
2020
5xFAD Alzheimer's Mouse Model
400 μg/kg IP daily; 28 days. Prevention of dendritic spine loss through MAPK/ERK pathway modulation.
2021