Weight
5-Amino-1MQ
Longevity
0
Amino acids
Molecular weight
Peptide
Type
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
Top researched benefits
Overview of 5-Amino-1MQ
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
longevity
- Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
- Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
- Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
metabolism
- Improvement through enhanced mitochondrial efficiency.
- Enhancement via cellular energy optimization.
- Improved glucose/fat substrate switching.
weight loss
- Supports increased basal metabolic rate.
- Improvements in fat burning capacity.
Typical Dose
50-100mg oral or 150-500mcg SubQ
Frequency
Once daily, preferably morning
Cycle Duration
8-12 weeks continuous
Storage
Oral: room temp. Injectable: lyophilized room temp or freezer, reconstituted 2-8°C for 28 days
No visual available
Due to this peptide having no amino acids, there is no molecular chain to display.
Chemical Makeup
Key benefits
Enhanced NAD+ levels
Improved mitochondrial function
Better energy metabolism
Enhanced cellular repair
Improved insulin sensitivity
Longevity support
Convenient daily oral dosing
Community interest
This peptide is still gaining traction in the community.
NNMT Inhibitor | Longevity & Metabolic Enhancement
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNo5-Amino-1MQ Protocols
Injectable protocols exist but vary widely. CRITICAL: Two vastly different protocols exist differing by 100-200x depending on units (mcg vs mg). Verify units before use.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Conservative starting (mcg protocol) | 150 | 1 week range | SubQ |
| Conservative standard (mcg protocol) | 250 | 1 week range | SubQ |
| Study-based (mg protocol) | 350 | 1 week range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- CRITICAL: Confirm protocol (mcg vs mg) before proceeding
- Clean vial stopper with alcohol
- Inject bacteriostatic water slowly down side of vial
- Gently swirl until dissolved (never shake)
- Label clearly with concentration AND units (mg/mL)
- Store in refrigerator
- Use within 28 days
5-Amino-1MQ Cycle
The 5-Amino-1MQ Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Gradual energy increase and mental clarity
- Week 2-4
- Enhanced exercise performance and recovery
- Week 4-8
- Improved metabolic markers and body composition
- Week 8-12
- Sustained longevity benefits and cellular health improvements
Dosing tools
5-Amino-1MQ Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
5-Amino-1MQ
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg 5-Amino-1MQ vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- 5-Amino-1MQ
- Dosing
- 50-100mg oral or 150-500mcg SubQ
- Dosing Frequency
- Once daily, preferably morning
- Cycle Duration
- 8-12 weeks continuous
- Storage
- Oral: room temp. Injectable: lyophilized room temp or freezer, reconstituted 2-8°C for 28 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of 5-Amino-1MQ interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
No known interactions; different mechanisms with potential complementary benefits.
Side effects
Contraindications
Pregnancy or breastfeeding
Pre-existing metabolic conditions (consult healthcare provider)
Stop signs
Severe gastrointestinal upset or persistent nausea
Unusual fatigue or weakness (opposite of expected effect)
Persistent headaches or dizziness
Sleep disturbances or insomnia
Allergic reactions (rash, swelling, difficulty breathing)
Significant mood changes or anxiety
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
5-Amino-1MQResearch References
5-Amino-1MQ is a preclinical compound
5-Amino-1MQ
5-Amino-1MQ is a preclinical compound
Mouse Obesity Study - Neelakantan et al.
Diet-induced obese mice showed 5.1% weight loss, 30% adipocyte size reduction at 60mg/kg/day. Human equivalent ~5mg/kg/day using FDA allometric scaling.
2018
Rat Pharmacokinetics Study
Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral) and 3.8hr (IV). Supports oral administration viability.
2021
Muscle Function in Aged Mice
40% grip strength improvement in sedentary mice, 60% with exercise at 10mg/kg/day SubQ for 8 weeks. No adverse effects observed.
2024