Weight
Cagrilintide
Metabolic
38
Amino acids
Molecular weight
Peptide
Type
Novel long-acting lipidated amylin analog functioning as dual amylin and calcitonin receptor agonist for weight management and type 2 diabetes. Phase 3 trials demonstrate 22.7% weight loss with CagriSema combination.
Top researched benefits
Overview of Cagrilintide
Subcutaneous injection enables optimal bioavailability, targeting dual amylin and calcitonin receptors for satiety and metabolic regulation. Enhances insulin sensitivity and controls gastric emptying.
weight loss
- Phase 3 trials demonstrate significant weight loss.
- 22.7% weight loss with CagriSema combination, surpassing existing therapies.
- 15.7% weight loss in diabetic patients with concurrent glycemic improvements.
metabolic
- 2.2% HbA1c reduction with CagriSema versus semaglutide alone.
- Amylin receptor activation enhances insulin sensitivity and glucose metabolism.
appetite control
- Dual pathway satiety via amylin and calcitonin receptor activation.
Typical Dose
2.4mg weekly (after escalation)
Frequency
Once weekly, same day each week
Cycle Duration
Continuous long-term therapy
Storage
Lyophilized: -20°C frozen; Reconstituted: 2-8°C refrigerated, use within 30 days
Chemical Makeup
Key benefits
FDA development candidate with extensive Phase 3 data
Superior weight loss in combination with semaglutide (22.7%)
Once-weekly convenience
2.2% HbA1c reduction with CagriSema
Community interest
This peptide is still gaining traction in the community.
Long-Acting Amylin Receptor Agonist | Weight Loss & Diabetes
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoCagrilintide Molecular Information
View the scientifc details of Cagrilintide.
38
Amino Acids
Cagrilintide
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?
Position 1
Lys
Lys
Position 2
Cys
Cys
Position 3
Asn
Asn
Position 4
Thr
Thr
Position 5
Ala
Ala
Position 6
Thr
Thr
Position 7
Cys
Cys
Position 8
Ala
Ala
Position 9
Thr
Thr
Position 10
Gln
Gln
Position 11
Arg
Arg
Position 12
Leu
Leu
Position 13
Ala
Ala
Position 14
Glu
Glu
Position 15
Phe
Phe
Position 16
Leu
Leu
Position 17
Arg
Arg
Position 18
His
His
Position 19
Ser
Ser
Position 20
Ser
Ser
Position 21
Asn
Asn
Position 22
Asn
Asn
Position 23
Phe
Phe
Position 24
Gly
Gly
Position 25
Pro
Pro
Position 26
Ile
Ile
Position 27
Leu
Leu
Position 28
Pro
Pro
Position 29
Pro
Pro
Position 30
Thr
Thr
Position 31
Asn
Asn
Position 32
Val
Val
Position 33
Gly
Gly
Position 34
Ser
Ser
Position 35
Asn
Asn
Position 36
Thr
Thr
Position 37
Pro
Pro
Position 38
Molecular Weight
4409DaChain Length
38Amino AcidsType
PeptideCagrilintide Protocols
Subcutaneous injection to abdomen, thigh, or upper arm. Pre-filled pen design when commercially available.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Weight Loss (Monotherapy) | 2.4 | 1 week range | SubQ |
| Weight Loss (CagriSema) | 2.4 | 1 week range | SubQ |
| Type 2 Diabetes Management | 2.4 | 1 week range | SubQ with metformin |
| Dose Escalation Protocol | 0.25 | 16 week range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- CRITICAL: Requires acidic pH (3.5-4.5) to prevent fibril formation
- Reconstitute slowly down vial side; swirl gently (do not shake)
- Verify pH 3.5-4.5 after reconstitution
- Solution must be clear—discard if cloudy or particulate
- Store refrigerated (2-8°C); inspect before each injection
- Allow 15-30 minutes to reach room temperature before injection
- Rotate injection sites weekly
Cagrilintide Cycle
The Cagrilintide Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Gastrointestinal adaptation; mild nausea possible during dose escalation
- Week 4-8
- Early weight loss (2-5%); noticeable appetite reduction
- Week 12-26
- Significant weight loss acceleration (10-15%); improved satiety signals
- Week 0-0
- Peak efficacy (15-23% weight loss); sustained maintenance with continued therapy
Dosing tools
Cagrilintide Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Cagrilintide
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Cagrilintide vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Cagrilintide
- Dosing
- 2.4mg weekly (after escalation)
- Dosing Frequency
- Once weekly, same day each week
- Cycle Duration
- Continuous long-term therapy
- Storage
- Lyophilized: -20°C frozen; Reconstituted: 2-8°C refrigerated, use within 30 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Cagrilintide interactions with other common peptides and substances.
Weight
ret
Metabolic
Retatrutide
MONITOR
Compounded GI side effects create substantial risk without specialist supervision.
Weight
sem
Metabolic
Semaglutide
SYNERGISTIC
CagriSema combination achieves enhanced weight loss through complementary GLP-1 and amylin pathways.
Side effects
Monitor: Be careful when combining Cagrilintide with Retatrutide.
Contraindications
Not recommended in pregnancy or breastfeeding
Not yet commercially available (FDA approval expected Q1 2026)
Stop signs
Severe persistent nausea/vomiting preventing hydration
Pancreatitis signs (severe abdominal pain radiating to back)
Severe allergic reactions or anaphylaxis
Significant injection site reactions or abscess formation
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
CagrilintideResearch References
Cagrilintide is an extensively studied compound
Cagrilintide
Cagrilintide is an extensively studied compound
REDEFINE 1 Trial - Phase 3 Weight Loss
3,417 adults with obesity; 22.7% weight loss with CagriSema vs 2.4% placebo. New England Journal of Medicine.
2025
REDEFINE 2 Trial - Phase 3 Type 2 Diabetes
1,206 adults; 15.7% weight loss; 73.5% achieved HbA1c ≤6.5%. New England Journal of Medicine.
2025
Phase 2 Type 2 Diabetes Combination Study
32 weeks; 15.6% weight loss; 2.2% HbA1c reduction with CagriSema. The Lancet.
2023