Reviewed by the PeptideMind Team · Updated July 15, 2026

SLU-PP-332 Dosage Guide, Benefits & Side Effects

SLU-PP-332 activates ERR receptors to mimic aerobic training, boosting endurance and fat loss up to 70% in treadmill studies. See research.

Chemical Makeup

44

Amino Acids

SLU-PP-332

Glu

E

Position 1

His

H

Position 2

Tyr

Y

Position 3

Asp

D

Position 4

Arg

R

Position 5

Pyl

O

Position 6

?

X

Position 7

Tyr

Y

Position 8

Asn

N

Position 9

Asn

N

Position 10

Ala

A

Position 11

Pro

P

Position 12

His

H

Position 13

Thr

T

Position 14

His

H

Position 15

Ala

A

Position 16

Leu

L

Position 17

Glu

E

Position 18

Asn

N

Position 19

Tyr

Y

Position 20

Leu

L

Position 21

Met

M

Position 22

Glu

E

Position 23

Thr

T

Position 24

His

H

Position 25

Tyr

Y

Position 26

Leu

L

Position 27

Glu

E

Position 28

Asn

N

Position 29

Glu

E

Position 30

Asx

B

Position 31

Glu

E

Position 32

Asn

N

Position 33

Glx

Z

Position 34

Pyl

O

Position 35

His

H

Position 36

Tyr

Y

Position 37

Asp

D

Position 38

Arg

R

Position 39

Ala

A

Position 40

Glx

Z

Position 41

Ile

I

Position 42

Asp

D

Position 43

Glu

E

Position 44

Amino acid sequence
Glutamic acidPosition 1
HistidinePosition 2
TyrosinePosition 3
Aspartic acidPosition 4
ArgininePosition 5
PyrrolysinePosition 6
?Position 7
TyrosinePosition 8
AsparaginePosition 9
AsparaginePosition 10
AlaninePosition 11
ProlinePosition 12
HistidinePosition 13
ThreoninePosition 14
HistidinePosition 15
AlaninePosition 16
LeucinePosition 17
Glutamic acidPosition 18
AsparaginePosition 19
TyrosinePosition 20
LeucinePosition 21
MethioninePosition 22
Glutamic acidPosition 23
ThreoninePosition 24
HistidinePosition 25
TyrosinePosition 26
LeucinePosition 27
Glutamic acidPosition 28
AsparaginePosition 29
Glutamic acidPosition 30
Aspartic acid or AsparaginePosition 31
Glutamic acidPosition 32
AsparaginePosition 33
Glutamic acid or GlutaminePosition 34
PyrrolysinePosition 35
HistidinePosition 36
TyrosinePosition 37
Aspartic acidPosition 38
ArgininePosition 39
AlaninePosition 40
Glutamic acid or GlutaminePosition 41
IsoleucinePosition 42
Aspartic acidPosition 43
Glutamic acidPosition 44

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SLU-PP-332 Dosage Guide for Fat Loss

SLU-PP-332 is a lab-made compound (not technically a peptide) that helps boost mitochondrial function and endurance, and is used for fat loss. All the dosing data we have comes from mouse studies — there's no human safety data yet.

Vial size

20 mg

Bacteriostatic water

2 mL

Dosing

250–500 mcg

Frequency

5 days on / 2 days off

Cycle

8–12 weeks

Benefit

Fat Loss

Explore calculators

SLU-PP-332 Dosage Guide for Performance / Lean Muscle

SLU-PP-332 is a lab-made compound (not technically a peptide) that helps boost mitochondrial function and endurance, often used to support performance and lean muscle. All the dosing data we have comes from mouse studies — there's no human safety data yet.

Vial size

20 mg

Bacteriostatic water

2 mL

Dosing

1–1.5 mg

Frequency

5 days on / 2 days off

Cycle

8–12 weeks

Benefit

Performance / Lean Muscle

Explore calculators

What is SLU-PP-332?

SLU-PP-332 is a lab-made compound (not a peptide) sometimes nicknamed 'exercise in a pill' because it turns on some of the same biological switches that regular exercise does, like helping muscle cells burn more fat and build more energy-producing power. So far it has only been tested in animals, largely because the current version doesn't absorb well when taken by mouth and clears from the body quickly. Researchers are studying it for obesity and metabolic health, with an improved successor compound already in development.

Longevity

Research targets include cellular aging, senescence, and long-term healthspan.

Metabolic

Research targets include glucose regulation, insulin sensitivity, and energy metabolism.

Metabolic

slu

Metabolic

Is SLU-PP-332 FDA approved?

SLU-PP-332 is not an FDA-approved drug. It is intended for research purposes only and is not approved for human consumption, diagnostic, or therapeutic use.

Research Use Only

SLU-PP-332 has not been evaluated by the FDA for safety or efficacy in humans.

No Clinical Oversight

Not manufactured under FDA-regulated quality or clinical standards.

Unregulated Sourcing

Purity, dosing, and sourcing are not verified through FDA testing or oversight.

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How Does SLU-PP-332 Work?

It directly switches on a family of receptors that control how many mitochondria a cell builds and how efficiently it burns fuel. Turning these receptors on essentially mimics, at the gene level, many of the same changes that regular endurance exercise produces in muscle and fat tissue.

Switches on a receptor family

Directly activates receptors that control mitochondria and fuel-burning.

Mimics exercise at the gene level

Turns on many of the same gene changes regular endurance training produces.

Boosts metabolism

Increases how efficiently muscle and fat tissue burn fuel.

SLU-PP-332 Targeted areas

How to reconstitute SLU-PP-332

View guide

The materials you'll need and step-by-step instructions for safely mixing SLU-PP-332 with bacteriostatic water.

Materials needed

Your SLU-PP-332 vial (lyophilized)

Alcohol swabs

Bacteriostatic sterile water

3 mL syringes (Luer Lock tip)

25G or 27G needles (Luer Lock). Other gauges may also be acceptable.

Sharps container (optional)

1

Remove the caps

Remove the caps from both your SLU-PP-332 vial and your bacteriostatic water vial.
2

Sanitize the rubber stoppers

Wipe down the rubber stoppers on both vials with alcohol swabs and let them dry for about 3 minutes.
3

Attach the needle

Take your 3 mL syringe and needle. Twist the needle's plastic hub into the Luer Lock tip on the syringe to secure it.
4

Draw the bac water

Pull back on the plunger to draw your desired volume of bacteriostatic water. If you overfill, just push the excess back in until you reach the right marker on the syringe.

How much bac water? SLU-PP-332 typically comes in a 20 mg vial. We recommend 2 mL of bacteriostatic water, though anywhere between 1 mL and 3 mL is acceptable. For larger vials you can use up to 5 mL — more bac water makes microdosing easier, but insulin needles usually max out at 1 mL per injection. That means a lot of bac water might force you into multiple injections to hit your target dose. Unless you're microdosing, 2 mL per vial is a solid rule of thumb.
5

Insert the needle into the SLU-PP-332 vial

With the bac water in your syringe, insert the needle into the SLU-PP-332 vial at a slight angle to avoid pressure buildup.

Use a thin needle: Stick to 25G or higher to avoid damaging the rubber stopper. Higher gauge means a thinner needle.
6

Release the water gently

Let the water run gently down the side of the vial. Don't inject it forcefully.

Heads up: Sometimes the plunger pushes itself in as soon as the needle enters the vial. Hold the plunger back so you have full control over how fast the bac water enters.
7

Swirl to dissolve

Avoid shaking. Gently swirl, flip, and roll the vial to dissolve the powder.

Be patient: This usually takes 2 to 5 minutes of consistent swirling, mixing in a circular motion, and gently flipping the vial up and down. The water needs to run through the powder many times to fully dissolve it. Don't shake or get aggressive with it.
8

Check for full dissolution

The solution should be clear with no visible particles. If it's cloudy or clumpy, wait a minute and repeat the swirling step.
9

Cap, dispose, and store

Once you're done, cap the needle and dispose of it (ideally in a sharps container). Store the reconstituted SLU-PP-332 vial in the fridge whenever it's not in use. It will stay good for approximately 30 days.

How to Store SLU-PP-332

The dry powder keeps in the freezer for at least four years. Dissolved in a lab solvent (DMSO), it needs a deep freezer for a few months or a regular freezer for just a month; once mixed into a water-based solution, refrigerate and use within about a month, avoiding repeated freezing and thawing.

Powder Storage

-20°C, stable for at least 4 years.

DMSO Solution Storage

-80°C for up to 6 months, or -20°C for 1 month.

Reconstituted Storage

In aqueous vehicle, 2–8°C for up to 28 days; avoid freeze-thaw cycles.

A smartphone displaying a "Storage Guide" for peptides, indicating a safe storage temperature range of 2–8°C, with warnings to keep away from light, heat, and freezing. The background is light blue, and additional tips on protecting the peptides are visible below the temperature range.

What Are the Benefits of SLU-PP-332?

What research says it may help with, and how it works in the body.

metabolic health

In obese mice, it significantly improved the body's ability to process blood sugar and lowered both fasting blood sugar and insulin levels.

Within 2 hours, it raises the amount of energy the body burns at rest by 25%, driven by increased burning of fat for fuel.

Reduced fatty liver disease, lowered fat levels stored in the liver, and improved the liver's ability to burn fat for energy.

Led to a 12% drop in body weight over 28 days without reducing appetite. Treated animals also gained less than 0.5 grams of fat, compared to about 5 grams in untreated animals.

exercise performance

In animal studies, it increased how long animals could run by 70% and how far they could run by 45%.

Increased the amount of a muscle fiber type built for endurance (type IIa), improving the muscles' ability to use oxygen for sustained energy.

antiaging

The first compound found to reverse age-related decline in the energy-producing parts of cells (mitochondria) in older, 21-month-old mice.

kidney protection

In elderly mice, it reversed the age-related rise in protein leaking into urine (a sign of kidney damage) and prevented the loss of specialized kidney filtering cells (podocytes).

cardiovascular

In heart failure studies, it improved the percentage of blood the heart pumps out with each beat (ejection fraction) and reduced stiff, scarred heart tissue (fibrosis).

What Are the Side Effects of SLU-PP-332?

Who should avoid it, warning signs to watch for, and what to know before combining it with other compounds.

Who Should Avoid It

NOT FOR HUMAN USE - no approved human dose

No human clinical trials conducted

Potential interaction with diabetes medications

Stop Right Away If You Notice

Severe hypoglycemia (especially with diabetes medications)

Any cardiovascular symptoms (chest pain, palpitations, shortness of breath)

Signs of liver dysfunction (jaundice, dark urine, severe abdominal pain)

Kidney problems (reduced urination, swelling, severe back pain)

Severe headaches or neurological symptoms

Allergic reactions (rash, hives, difficulty breathing, swelling)

Milder Signs to Watch For

Any product marketed for human consumption is illegalUnknown purity or contamination without lab testingLack of proper HPLC or mass spectrometry verificationProducts without 'Research Use Only' labeling
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How Long Should a SLU-PP-332 Cycle Last?

This breaks down how long a typical SLU-PP-332 cycle runs and what research suggests happens at each stage. Research shows that staying on a peptide continuously, without a break, may make it less effective over time.

That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again.

Week 0-0
Metabolic shift toward fat oxidation within 2 hours; gene expression changes at 3-6 hours; enhanced exercise performance 1 hour post-dose
Week 0-0
Increased resting energy expenditure measurable; enhanced fatty acid oxidation by 25%; improved grip strength by day 6
Week 2-4
Up to 12% weight loss by day 28; dramatic fat mass reduction; improved glucose tolerance; 45-70% endurance improvements; reduced hepatic steatosis
Week 6-8
Cardiac improvements (ejection fraction, reduced fibrosis); age-related kidney dysfunction reversal; mitochondrial architecture restoration
Week 0-0
Sustained anti-aging effects in aging studies; continued tissue mitochondrial improvement; duration after discontinuation unknown

Cheat Sheets Featuring SLU-PP-332

See how SLU-PP-332 fits into a broader research stack with these free downloadable cheat sheets. Each one includes reference dose ranges, dosing frequency, and half-life for every peptide it covers. For research purposes only.

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Longevity Peptide Cheat Sheet
Longevity Peptide Cheat Sheet

42 peptides

Master Peptide Cheat Sheet
Master Peptide Cheat Sheet

78 peptides

Metabolic Peptide Cheat Sheet
Metabolic Peptide Cheat Sheet

14 peptides

SLU-PP-332 Research References

It is a preclinical compound

4Research references

SLU-PP-332

SLU-PP-332 is a preclinical compound

Synthetic ERRα/β/γ Agonist Induces Acute Aerobic Exercise Response

Multiple mouse models, 50 mg/kg IP: 70% increase in running time, 45% increase in running distance, increased type IIa oxidative muscle fibers.

2023

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction in Aging Kidney

21-month-old mice, 8-week treatment: Reversed age-related kidney decline, reduced albuminuria, prevented podocyte loss, restored mitochondrial architecture.

2023

A Synthetic ERR Agonist Alleviates Metabolic Syndrome

Diet-induced obese mice, 50 mg/kg IP twice daily, 28 days: 12% body weight loss, 25% fatty acid oxidation increase, improved glucose tolerance, reduced hepatic steatosis.

2024

Cardiac Protective Effects of Pan-ERR Agonists

Heart failure models, 6-week treatment: Improved ejection fraction, ameliorated cardiac fibrosis, improved survival, enhanced mitochondrial ultrastructure.

2021

Frequently Asked Questions About SLU-PP-332

Straight answers on reconstitution, dosing, and safety, everything you need to research with confidence. For research reference only.