Healing
Vesugen
Longevity
3
Amino acids
Molecular weight
Peptide
Type
Vesugen is a Khavinson bioregulator tripeptide developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology. Composed of three amino acids (lysine, glutamic acid, aspartic acid), it targets the vascular system and protects blood vessels from age-related decline. Research shows it limits atherosclerosis development, decreases endothelial dysfunction, and activates stem cells. Like other short Khavinson peptides, Vesugen penetrates to the nucleus where it influences gene expression.
Top researched benefits
Overview of Vesugen
Vesugen works through epigenetic regulation by interacting with DNA promoter regions, particularly affecting Ki-67 gene expression which controls cell division. It plays a prominent role in regulating sirtuin 1 (SIRT1) protein levels - a key anti-aging protein activated during calorie restriction. Vesugen enhances mesenchymal stem cell proliferation, reduces senescence markers, improves cell differentiation, and may reverse the Senescence-Associated Secretory Phenotype (SASP) implicated in age-related cardiovascular disease.
vascular health
- Protects blood vessels from age-related deterioration through gene expression regulation.
- Limits development of atherosclerotic plaques in blood vessels.
- Decreases endothelial dysfunction that contributes to cardiovascular disease.
antiaging
- Regulates sirtuin 1 levels, mimicking some benefits of calorie restriction.
- Enhances mesenchymal stem cell proliferation and reduces senescence.
- Reverses senescence-associated secretory phenotype in aging cells.
Typical Dose
10-20 mg per day (oral capsules) or 10 mg (injectable)
Frequency
Daily for 10-20 consecutive days (Khavinson bioregulator cycle)
Cycle Duration
10-20 day cycle
Storage
Oral capsules: room temperature; Lyophilized powder/reconstituted: 2-8°C refrigerated
Chemical Makeup
Key benefits
Protects vascular system from aging effects
Limits atherosclerosis development
Decreases endothelial cell dysfunction
Activates SIRT1 anti-aging pathway
Enhances stem cell proliferation
Reduces cellular senescence markers
Reverses SASP phenotype
Works synergistically with Cardiogen
Community interest
This peptide is still gaining traction in the community.
KED | Vascular Bioregulator Peptide
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoVesugen Molecular Information
View the scientifc details of Vesugen.
3
Amino Acids
Vesugen
Lys
Lys
Position 1
Glu
Glu
Position 2
Asp
Asp
Position 3
Molecular Weight
390.39DaChain Length
3Amino AcidsType
PeptideVesugen Protocols
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard protocol | 10 | 10 week range | Oral capsules |
| Maintenance | 10 | 2 week range | Oral capsules |
Vesugen Cycle
The Vesugen Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Gene expression modulation and SIRT1 activation begins
- Week 0-0
- Effects persist due to epigenetic changes
- Week 0-0
- Vascular function improvements
- Week 0-0
- Cumulative benefits with periodic cycles
Dosing tools
Vesugen Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Vesugen
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Vesugen vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Vesugen
- Dosing
- 10-20 mg per day (oral capsules) or 10 mg (injectable)
- Dosing Frequency
- Daily for 10-20 consecutive days (Khavinson bioregulator cycle)
- Cycle Duration
- 10-20 day cycle
- Storage
- Oral capsules: room temperature; Lyophilized powder/reconstituted: 2-8°C refrigerated
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Vesugen interactions with other common peptides and substances.
Healing
car
Longevity
Cardiogen
SYNERGISTIC
Complementary cardiovascular bioregulators - Vesugen for vessels, Cardiogen for heart tissue.
Longevity
epi
Immunity
Epitalon
SYNERGISTIC
Often combined in comprehensive anti-aging Khavinson protocols.
Cognitive
pin
Longevity
Pinealon
COMPATIBLE
Part of Khavinson bioregulator family; targets different tissue.
Longevity
thy
Immunity
Thymalin
COMPATIBLE
Different organ targets; can be used in comprehensive bioregulator protocols.
Side effects
Contraindications
Active cardiovascular emergencies (seek medical care)
Known hypersensitivity
Pregnancy or breastfeeding
Stop signs
Allergic reactions
Unusual cardiovascular symptoms
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
VesugenResearch References
Vesugen is a moderate research compound
Vesugen
Vesugen is a moderate research compound
Khavinson Peptide Bioregulators Research
Comprehensive review of bioregulator peptides including Vesugen and their epigenetic mechanisms.
n.d.
Short Peptides and Vascular Aging
Short peptides regulate sirtuin 1 levels and protect vascular tissue from aging.
n.d.
Mesenchymal Stem Cell Activation by Peptide Bioregulators
Vesugen enhances MSC proliferation and reduces senescence markers in stem cells.
n.d.