Healing
Vesugen
Longevity
3
Amino acids
Molecular weight
Peptide
Type
Vesugen (KED) is a short-chain tripeptide bioregulator composed of lysine, glutamic acid, and aspartic acid, developed at the St. Petersburg Institute of Bioregulation and Gerontology. It acts as an epigenetic modulator in vascular endothelial cells, upregulating Ki-67-mediated cell proliferation and SIRT1 pathway activity to counteract age-related vascular decline. It is used in longevity and anti-aging research, with limited clinical data from Russian geriatric studies.
Top researched benefits
Overview of Vesugen
Vesugen interacts with DNA promoter regions in vascular endothelial cells to epigenetically modulate gene transcription, upregulating Ki-67 expression to stimulate endothelial cell proliferation and activating SIRT1 to promote nitric oxide-dependent vascular relaxation, reduce endothelin-1 dysregulation, and enhance antioxidative enzyme activity.
vascular health
- Protects blood vessels from age-related deterioration through gene expression regulation.
- Limits development of atherosclerotic plaques in blood vessels.
- Decreases endothelial dysfunction that contributes to cardiovascular disease.
antiaging
- Regulates sirtuin 1 levels, mimicking some benefits of calorie restriction.
- Enhances mesenchymal stem cell proliferation and reduces senescence.
- Reverses senescence-associated secretory phenotype in aging cells.
Typical Dose
500–2000 mcg per injection
Frequency
once daily
Cycle Duration
2–3 week cycles, repeated 2–3 times per year
Storage
Lyophilized: store at -20°C in dry, dark conditions. Reconstituted: refrigerate at 2–8°C, use within 28 days; avoid freeze-thaw cycles.
Chemical Makeup
Key benefits
Stimulates vascular endothelial cell proliferation by upregulating Ki-67 gene expression, helping maintain vessel wall integrity in aging tissue
Activates SIRT1 signaling to improve insulin sensitivity and provide geroprotective effects analogous to caloric restriction
Reduces endothelin-1 dysregulation and promotes nitric oxide-dependent arterial relaxation, supporting flexible and responsive blood vessels
Attenuates atherosclerotic plaque development and restenosis by protecting endothelial cells from oxidative stress and age-related damage
Community interest
This peptide is still gaining traction in the community.
Vascular Bioregulator | Endothelial Health & Longevity
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoVesugen Molecular Information
View the scientifc details of Vesugen.
3
Amino Acids
Vesugen
Lys
Lys
Position 1
Glu
Glu
Position 2
Asp
Asp
Position 3
Molecular Weight
390.39DaChain Length
3Amino AcidsType
PeptideVesugen Protocols
Subcutaneous injection is the advanced route for Vesugen, offering faster onset of vascular endothelial effects (within 3–4 days versus 10 days orally). Preferred sites include the abdomen and upper arms with systematic rotation; morning administration is standard for this Khavinson bioregulator.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Vascular health / standard SubQ dose | 1000 | 1 day range | SubQ |
| Titration — Week 1 ramp | 500 | 1 day range | SubQ |
| Titration — Week 2 ramp | 1000 | 1 day range | SubQ |
| Titration — Week 3+ maintenance | 1500 | 1 day range | SubQ |
| Intramuscular — advanced vascular support | 1000 | 1 day range | IM |
| Long-term anti-aging / vascular maintenance | 1000 | 1 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Remove the Vesugen vial from the freezer and allow it to reach room temperature before reconstitution.
- Draw 3.0 mL of bacteriostatic water into a separate 3 mL draw syringe (18–21 gauge needle); do not use an insulin syringe for this step.
- Clean the vial stopper with an alcohol swab and allow it to dry fully before inserting the needle.
- Insert the draw syringe needle through the stopper and inject the bacteriostatic water slowly down the inner wall of the vial — never directly onto the lyophilized powder.
- Gently swirl or roll the vial until the powder fully dissolves. Do not shake or agitate vigorously to avoid foaming and peptide degradation.
- The resulting solution is approximately 6.67 mg/mL (6670 mcg/mL). Label the vial with the date of reconstitution.
- Store reconstituted vial refrigerated at 2–8°C (35.6–46.4°F); use within 28 days. Do not freeze reconstituted solution.
- Draw the target dose volume into a fresh insulin syringe (0.5–1 mL, 29–31 gauge). At 6.67 mg/mL, 500 mcg = 7.5 units and 1000 mcg = 15 units on a U-100 syringe.
- Clean the injection site with an alcohol swab and allow to dry. Pinch a fold of skin and insert the needle at a 45–90° angle into subcutaneous tissue.
- Inject slowly and steadily without aspirating. Withdraw the needle and apply gentle pressure with a clean swab.
- Rotate injection sites systematically among the abdomen, thighs, and upper arms to reduce local irritation.
Vesugen Cycle
The Vesugen Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Gene expression modulation and SIRT1 activation begins
- Week 0-0
- Effects persist due to epigenetic changes
- Week 0-0
- Vascular function improvements
- Week 0-0
- Cumulative benefits with periodic cycles
Dosing tools
Vesugen Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Vesugen
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Vesugen vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Vesugen
- Dosing
- 500–2000 mcg per injection
- Dosing Frequency
- once daily
- Cycle Duration
- 2–3 week cycles, repeated 2–3 times per year
- Storage
- Lyophilized: store at -20°C in dry, dark conditions. Reconstituted: refrigerate at 2–8°C, use within 28 days; avoid freeze-thaw cycles.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Vesugen interactions with other common peptides and substances.
Healing
car
Longevity
Cardiogen
SYNERGISTIC
Complementary cardiovascular bioregulators - Vesugen for vessels, Cardiogen for heart tissue.
Longevity
epi
Immunity
Epitalon
SYNERGISTIC
Often combined in comprehensive anti-aging Khavinson protocols.
Cognitive
pin
Longevity
Pinealon
COMPATIBLE
Part of Khavinson bioregulator family; targets different tissue.
Longevity
thy
Immunity
Thymalin
COMPATIBLE
Different organ targets; can be used in comprehensive bioregulator protocols.
Side effects
Contraindications
Active cardiovascular emergencies (seek medical care)
Known hypersensitivity
Pregnancy or breastfeeding
Stop signs
Allergic reactions
Unusual cardiovascular symptoms
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
VesugenResearch References
Vesugen is a preclinical compound
Vesugen
Vesugen is a preclinical compound
Khavinson Peptide Bioregulators Research
Comprehensive review of bioregulator peptides including Vesugen and their epigenetic mechanisms.
n.d.
Short Peptides and Vascular Aging
Short peptides regulate sirtuin 1 levels and protect vascular tissue from aging.
n.d.
Mesenchymal Stem Cell Activation by Peptide Bioregulators
Vesugen enhances MSC proliferation and reduces senescence markers in stem cells.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
