Cognitive
NA-Selank Amidate
Longevity
7
Amino acids
Molecular weight
Peptide
Type
NA-Selank Amidate (N-Acetyl Selank Amidate) is a synthetically modified heptapeptide derived from Selank, featuring N-terminal acetylation and C-terminal amidation that enhance blood-brain barrier penetration and resistance to enzymatic degradation. It modulates GABAergic, serotonergic, and BDNF-mediated pathways to produce anxiolytic and nootropic effects without the sedation or dependence associated with benzodiazepines. Researchers use it as a more stable and bioavailable alternative to native Selank for studying anxiety, stress resilience, and cognitive function.
Top researched benefits
Overview of NA-Selank Amidate
NA-Selank Amidate allosterically modulates GABA-A receptors and inhibits enkephalin-degrading enzymes, while upregulating BDNF expression and modulating serotonin metabolism. The N-acetyl and C-terminal amide modifications protect the peptide from aminopeptidase and carboxypeptidase degradation, extending its activity window and enhancing CNS penetration relative to native Selank.
anxiety and mood
- Standard Selank approved in Russia for GAD; NA-Selank Amidate offers enhanced delivery.
- Modulates stress response through GABA and serotonin systems without sedation.
- Improves mood through serotonin metabolism activation.
cognitive enhancement
- Increases memory trace stability for up to 30 days in animal studies.
- BDNF elevation supports learning and neuroplasticity.
- BDNF increase reduces effects of neurological injury.
immune support
- Based on tuftsin structure, retains immunomodulatory properties.
Typical Dose
200–500mcg per dose
Frequency
1–2 times daily via intranasal spray or subcutaneous injection
Cycle Duration
14 days on, 1–3 weeks washout
Storage
Lyophilized: -20°C, protected from light, stable up to 12 months. Reconstituted: 2–8°C for up to 28 days. Do not freeze reconstituted solution.
Chemical Makeup
Key benefits
Reduces anxiety symptoms without causing sedation or benzodiazepine-like dependence through GABA-A receptor allosteric modulation
Enhances memory consolidation and learning capacity by upregulating BDNF, a key mediator of neuronal plasticity
Improves stress tolerance by modulating hypothalamic-pituitary-adrenal axis signaling and reducing stress-related cytokine expression including IL-6
Increases bioavailability and CNS penetration versus native Selank due to N-acetylation and C-terminal amidation modifications
Community interest
This peptide is still gaining traction in the community.
Anxiolytic Nootropic | Anxiety & Cognitive Enhancement
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoNA-Selank Amidate Molecular Information
View the scientifc details of NA-Selank Amidate.
7
Amino Acids
NA-Selank Amidate
Thr
Thr
Position 1
Lys
Lys
Position 2
Pro
Pro
Position 3
Arg
Arg
Position 4
Pro
Pro
Position 5
Gly
Gly
Position 6
Pro
Pro
Position 7
Molecular Weight
793.92DaChain Length
7Amino AcidsType
PeptideNA-Selank Amidate Protocols
Subcutaneous injection is one of two primary delivery routes for NA-Selank Amidate and requires reconstitution of the lyophilized powder with bacteriostatic water before use. The abdomen or upper thigh are preferred injection sites; rotating sites each dose prevents lipohypertrophy.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Anxiety reduction | 250 | 1 day range | SubQ |
| Cognitive enhancement / nootropic | 300 | 1 day range | SubQ |
| Stress resistance and adaptogen | 250 | 2 day range | SubQ |
| PTSD and mood stabilization | 300 | 2 day range | SubQ |
| Immune modulation | 150 | 1 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Allow the NA-Selank Amidate vial to reach room temperature before reconstitution
- Draw 3 mL of bacteriostatic water into a sterile syringe
- Inject the bacteriostatic water slowly down the inner wall of the vial — never directly onto the powder
- Gently swirl or roll the vial between your palms until the powder is fully dissolved — do not shake
- Label the vial with the date and store at 2–8°C, away from light; use within 28 days
- Draw the desired dose into an insulin syringe, expel any air bubbles before injecting
- Clean the injection site (abdomen 2 inches from the navel or upper thigh) with an alcohol swab and let dry
- Pinch the skin to create a fold, insert the needle at a 45–90 degree angle, and inject slowly over 3–5 seconds
- Withdraw the needle, apply light pressure with a clean swab, and rotate to a different site next dose
NA-Selank Amidate Cycle
The NA-Selank Amidate Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Anxiolytic effects begin; reduced stress response
- Day 1-3
- Nootropic effects become noticeable
- Week 1-2
- Full anxiolytic and cognitive benefits
- Week 0-0
- Benefits persist for approximately 1 week after 14-day course
Dosing tools
NA-Selank Amidate Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
NA-Selank Amidate
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg NA-Selank Amidate vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- NA-Selank Amidate
- Dosing
- 200–500mcg per dose
- Dosing Frequency
- 1–2 times daily via intranasal spray or subcutaneous injection
- Cycle Duration
- 14 days on, 1–3 weeks washout
- Storage
- Lyophilized: -20°C, protected from light, stable up to 12 months. Reconstituted: 2–8°C for up to 28 days. Do not freeze reconstituted solution.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of NA-Selank Amidate interactions with other common peptides and substances.
Cognitive
sema
Longevity
Semax
SYNERGISTIC
Often combined for comprehensive cognitive enhancement and mood support.
Side effects
Contraindications
Pregnancy or breastfeeding
Known hypersensitivity to Selank or tuftsin
Severe psychiatric conditions (consult professional)
Stop signs
Allergic reactions
Paradoxical anxiety increase
Unusual mood changes
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
NA-Selank AmidateResearch References
NA-Selank Amidate is an experimental compound
NA-Selank Amidate
NA-Selank Amidate is an experimental compound
Selank Administration Affects Expression of Genes in GABAergic Neurotransmission
Selank modulates GABAA receptor activity, contributing to anxiolytic effects without benzodiazepine-like side effects.
n.d.
Selank Clinical Trial in Anxiety Disorders
14 days of intranasal Selank produced pronounced anxiolytic and mild nootropic effects; benefits persisted 1 week post-treatment.
n.d.
Selank and Serotonin Metabolism
Single Selank injection activated serotonin metabolism and increased memory trace stability for up to 30 days.
n.d.
Selank and BDNF Expression
Selank administration increases BDNF levels, supporting neuronal growth and memory enhancement.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
