Cognitive
Cortagen
Longevity
4
Amino acids
Molecular weight
Peptide
Type
Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it regulates inflammatory responses in the nervous system, restores balance between pro- and anti-oxidative processes, and stimulates interleukin-2 expression. Research shows potential benefits for ischemic brain injury recovery, nerve regeneration, and reducing autoimmune reactions affecting the CNS.
Top researched benefits
Overview of Cortagen
Cortagen works through epigenetic regulation by penetrating cell nuclei and interacting with DNA to modulate gene expression. In the heart, it affects genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15, and Eps15-rs. It powerfully regulates inflammatory responses in the nervous system, helping restore proper balance between oxidative and anti-oxidative processes. Cortagen stimulates IL-2 expression and helps regulate immune function, particularly by reducing autoimmune reactions.
neurological support
- Shows beneficial long-term results in research following ischemic brain injury.
- Research demonstrates effects on restoration of injured nerve function.
- Regulates inflammatory response in the nervous system.
immune regulation
- Helps regulate immune function by reducing autoimmune reactions.
- Stimulates interleukin-2 expression for immune regulation.
antiaging
- Restores balance between pro- and anti-oxidative processes.
- Addresses age-related CNS changes through bioregulation.
Typical Dose
10-20 mg daily
Frequency
Once daily for 10-20 consecutive days
Cycle Duration
10-20 days per cycle
Storage
Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated
Chemical Makeup
Key benefits
Regulates central nervous system function
Powerful anti-inflammatory effects in brain
Supports nerve regeneration
Restores oxidative balance
Stimulates interleukin-2 expression
Reduces autoimmune reactions
Beneficial after ischemic brain injury
Modulates gene expression in neural tissue
Community interest
This peptide is still gaining traction in the community.
AEDP | Brain Cortex Bioregulator Peptide
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoCortagen Molecular Information
View the scientifc details of Cortagen.
4
Amino Acids
Cortagen
Ala
Ala
Position 1
Glu
Glu
Position 2
Asp
Asp
Position 3
Pro
Pro
Position 4
Molecular Weight
430.4DaChain Length
4Amino AcidsType
PeptideCortagen Protocols
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard protocol | 10 | 10 week range | Oral capsules |
| Maintenance | 10 | 2 week range | Oral capsules |
Cortagen Cycle
The Cortagen Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Gene expression modulation begins
- Week 0-0
- Effects persist due to epigenetic changes
- Week 0-0
- Neurological function improvements
- Week 0-0
- Cumulative benefits with periodic cycles
Dosing tools
Cortagen Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Cortagen
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Cortagen vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Cortagen
- Dosing
- 10-20 mg daily
- Dosing Frequency
- Once daily for 10-20 consecutive days
- Cycle Duration
- 10-20 days per cycle
- Storage
- Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Cortagen interactions with other common peptides and substances.
Healing
car
Longevity
Cardiogen
COMPATIBLE
Part of Khavinson bioregulator family; targets different tissue.
Longevity
epi
Immunity
Epitalon
SYNERGISTIC
Often combined in comprehensive anti-aging Khavinson protocols.
Cognitive
pin
Longevity
Pinealon
SYNERGISTIC
Complementary CNS bioregulators; Cortagen for cortex, Pinealon for general brain.
Longevity
thy
Immunity
Thymalin
COMPATIBLE
Different organ targets; can be used in comprehensive bioregulator protocols.
Side effects
Contraindications
Active neurological emergencies (seek medical care)
Known hypersensitivity
Pregnancy or breastfeeding
Stop signs
Allergic reactions
Unusual neurological symptoms
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
CortagenResearch References
Cortagen is a moderate research compound
Cortagen
Cortagen is a moderate research compound
Effect of Cortagen on Gene Expression in Mouse Heart
Cortagen affects expression of genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15 in heart tissue.
n.d.
Delayed Effect of Cortagen on Restoration of Injured Nerve Function
Demonstrated effects on nerve function restoration following injury.
n.d.
Effect of Tetrapeptide Cortagen on Regeneration of Sciatic Nerve
Research on nerve regeneration effects of Cortagen tetrapeptide.
n.d.
Khavinson Peptide Bioregulators
Comprehensive review of bioregulator peptides and their epigenetic mechanisms.
n.d.