Longevity
Chonluten
Immunity
3
Amino acids
Molecular weight
Peptide
Type
Chonluten is a synthetic tripeptide (Glu-Asp-Gly) developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a peptide bioregulator targeting the bronchopulmonary system. It modulates gene expression in respiratory epithelial cells by interacting with histone proteins and DNA promoter regions, restoring normal transcriptional activity in bronchial tissue. It is used in gerontology research and longevity protocols for respiratory health maintenance, particularly in aging populations and those with chronic respiratory conditions.
Top researched benefits
Overview of Chonluten
Chonluten penetrates cell nuclei and binds to histone proteins (H1, H2b, H3, H4) and specific DNA promoter regions, epigenetically modulating transcription of genes governing stress response (c-Fos, HSP70), antioxidant defense (superoxide dismutase), and inflammation (COX-2, TNF-alpha suppression) in bronchial epithelial cells.
respiratory support
- Normalizes respiratory system function through gene expression regulation.
- Restores and maintains lung alveolar tissues and bronchial mucous membranes.
- May modulate mucosal function in chronic obstructive pulmonary disease.
antiinflammatory
- Inhibits TNF production in monocytes, reducing inflammatory responses.
- Supports SOD and antioxidant gene expression.
antiaging
- Researched as potential agent that may slow cell aging.
- Modulates c-Fos and proliferative gene activity.
Typical Dose
200–400mcg per day
Frequency
once daily
Cycle Duration
10–30 day course, repeated 2–3 times per year
Storage
Lyophilized: 2–8°C in original packaging, protected from light and moisture. Reconstituted: 2–8°C, use within 14–28 days.
Chemical Makeup
Key benefits
Restores normal gene expression patterns in bronchial epithelial cells, supporting structural integrity of the respiratory mucosa
Suppresses TNF-alpha, IL-6, and IL-17 production, reducing chronic inflammation in bronchial and lung tissue
Upregulates superoxide dismutase (SOD) activity, protecting respiratory epithelium from oxidative stress-induced damage
Inhibits COX-2 expression in bronchial cells, attenuating inflammatory cascades associated with COPD and chronic bronchitis
Community interest
This peptide is still gaining traction in the community.
Bronchopulmonary Bioregulator | Respiratory & Longevity
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoChonluten Molecular Information
View the scientifc details of Chonluten.
3
Amino Acids
Chonluten
Glu
Glu
Position 1
Asp
Asp
Position 2
Gly
Gly
Position 3
Molecular Weight
319.27DaChain Length
3Amino AcidsType
PeptideChonluten Protocols
Chonluten capsules are the most common consumer delivery form, providing convenient daily dosing for lung and bronchial mucosa support. Each capsule contains 10 mg of synthesized peptides and is taken before meals; courses of 10–30 days are repeated 2–3 times per year.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| General Respiratory Maintenance | 10 | 1 day range | Oral (empty stomach) |
| Enhanced Lung Support | 20 | 1 day range | Oral (with meals) |
| Anti-Aging / Longevity Protocol (Ages 40–50) | 10 | 2 day range | Oral (empty stomach) |
| Anti-Aging / Longevity Protocol (Ages 50+) | 20 | 2 day range | Oral (empty stomach) |
| Bronchial Tissue Repair | 10 | 2 day range | Oral (empty stomach) |
Chonluten Cycle
The Chonluten Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Gene expression modulation and anti-inflammatory effects begin
- Week 0-0
- Effects persist due to epigenetic changes
- Week 0-0
- Respiratory function improvements
- Week 0-0
- Cumulative benefits with periodic cycles
Dosing tools
Chonluten Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Chonluten
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Chonluten vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Chonluten
- Dosing
- 200–400mcg per day
- Dosing Frequency
- once daily
- Cycle Duration
- 10–30 day course, repeated 2–3 times per year
- Storage
- Lyophilized: 2–8°C in original packaging, protected from light and moisture. Reconstituted: 2–8°C, use within 14–28 days.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Chonluten interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Both support mucosal health through different mechanisms.
Immunity
bro
Bronchogen
SYNERGISTIC
Related respiratory bioregulators; complementary mechanisms.
Longevity
cry
Immunity
Crystagen
COMPATIBLE
Both have immune-modulating properties; different tissue targets.
Longevity
epi
Immunity
Epitalon
SYNERGISTIC
Often combined in comprehensive anti-aging Khavinson protocols.
Side effects
Contraindications
Active respiratory emergencies (seek medical care)
Known hypersensitivity
Pregnancy or breastfeeding
Stop signs
Allergic reactions
Unusual respiratory symptoms
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
ChonlutenResearch References
Chonluten is a preclinical compound
Chonluten
Chonluten is a preclinical compound
Peptides Regulating Proliferative Activity and Inflammatory Pathways in THP-1 Cells
Chonluten tripeptide inhibits TNF production in monocytes exposed to pro-inflammatory LPS.
n.d.
Chonluten and Gene Expression Regulation
Chonluten regulates c-Fos, HSP70, SOD, COX-2, and TNF-alpha gene expression.
n.d.
Bronchial Bioregulator Peptides
Short peptides derived from bronchial tissue regulate protein synthesis in lung cells.
n.d.
Khavinson Peptide Bioregulators
Comprehensive review of bioregulator peptides including Chonluten and their mechanisms.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
