Cognitive
Dihexa
Longevity
2
Amino acids
Molecular weight
Peptide
Type
Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis. It is 10 million times more potent than BDNF at promoting synapse formation through HGF/c-Met receptor activation.
Top researched benefits
Overview of Dihexa
Binds to hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and potentiates its activity at c-Met receptor, activating PI3K/AKT pathways and promoting new synaptic connections with extraordinary potency.
Cognitive
- Improvements in spatial, working, and consolidation demonstrated across animal models.
- Enhanced acquisition through increased synaptic plasticity.
- Restoration in impairment models including scopolamine-induced amnesia.
Neuroprotection
- Reduced amyloid burden in Alzheimer's models.
- Decreased neuroinflammation and glial activation.
- Protection of synapses in neurodegeneration models.
Neuroplasticity
- 3-fold increase in dendritic spine formation demonstrated.
- Increases brain-derived neurotrophic factor expression.
- Promotes new blood vessel formation in brain.
Storage
Oral: room temperature (2 year shelf life); Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C, use within 30 days
Frequency
Once daily in the morning
Typical Dose
8-10mg oral or 2-5mg injectable (0.5mg/kg based on research)
Cycle Duration
4-8 weeks on
Chemical Makeup
Key benefits
Dramatic synaptogenesis promotion
10 million times more potent than BDNF
Cognitive enhancement and memory improvement
Neuroprotection and potential neuroregeneration
Applications for Alzheimer's, TBI, age-related cognitive decline
Oral bioavailability
Community interest
This peptide is still gaining traction in the community.
Synaptogenic Peptide | Cognitive Enhancement
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesDihexa Molecular Information
View the scientifc details of Dihexa.
2
Amino Acids
Dihexa
Tyr
Tyr
Position 1
Ile
Ile
Position 2
Molecular Weight
504.7DaChain Length
2Amino AcidsType
PeptideDihexa Protocols
Oral capsules/tablets are the most convenient form. Take in the morning with or without food. No reconstitution required.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard cognitive enhancement | 8 | 1 week range | Oral |
| Low-dose maintenance | 5 | 1 week range | Oral |
| Intensive learning protocol | 10 | 1 week range | Oral |
Dihexa Cycle
The Dihexa Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Subtle cognitive shifts; possible headaches during adaptation
- Week 2-4
- Improved focus and memory formation
- Week 4-8
- Peak cognitive benefits and enhanced learning
- Week 0-0
- Effects may persist for days to weeks after discontinuation
Dosing tools
Dihexa Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
Dihexa
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Dihexa vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- Dihexa
- Dosing
- 8-10mg oral or 2-5mg injectable (0.5mg/kg based on research)
- Dosing Frequency
- Once daily in the morning
- Cycle Duration
- 4-8 weeks on
- Storage
- Oral: room temperature (2 year shelf life); Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C, use within 30 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Dihexa interactions with other common peptides and substances.
Cognitive
cer
Longevity
Cerebrolysin
MONITOR
Both potently neuroactive; may cause overstimulation.
Cognitive
sel
Longevity
Selank
COMPATIBLE
Synergistic effects; watch for neural overstimulation.
Cognitive
sema
Longevity
Semax
COMPATIBLE
Enhanced cognitive benefits; monitor for overstimulation.
Side effects
Avoid: Do not take Dihexa with P21.
Monitor: Be careful when combining Dihexa with Cerebrolysin.
Contraindications
Not FDA approved - research compound only
Theoretical cancer risk via c-Met activation
Cancer history (avoid due to c-Met pathway)
Pregnancy or breastfeeding
No long-term human safety data
Stop signs
Severe or persistent headaches
Increasing anxiety or panic attacks
Significant mood changes or depression
Sleep disturbance beyond 3 days
Concerning neurological symptoms
Signs of overstimulation or mania
Injection site reactions (if injectable)
Bad signs
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Frequently asked questions
What benefits can peptides offer in research?
Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.
What are some exciting applications of peptides in modern science?
Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.
How do peptides influence health and wellness?
Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.
Where can I find the latest studies on peptide applications?
Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.
Are there any guidelines for using peptides in research?
Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.
What is the difference between peptides and proteins?
Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.
How should peptides be stored?
Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.
Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
DihexaResearch References
Dihexa is an emerging compound
Dihexa
Dihexa is an emerging compound
Injectable Route Efficacy Study
Intraperitoneal injection at 0.5mg/kg/day completely reversed scopolamine-induced cognitive deficits (p<0.001), with performance indistinguishable from healthy controls.
2013
APP/PS1 Alzheimer's Model Study
Dihexa restored spatial learning and memory in Morris water maze tests, increased neuronal cells and synaptophysin expression, reduced neuroinflammation.
2021
Synaptogenic Potency Study
Demonstrated to be 10 million times more effective than BDNF at promoting synapse formation through HGF/c-Met receptor activation.
2014