Cognitive
Dihexa
Longevity
2
Amino acids
Molecular weight
Peptide
Type
Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis. It is 10 million times more potent than BDNF at promoting synapse formation through HGF/c-Met receptor activation.
Top researched benefits
Overview of Dihexa
Binds to hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and potentiates its activity at c-Met receptor, activating PI3K/AKT pathways and promoting new synaptic connections with extraordinary potency.
cognitive
- Improvements in spatial, working, and consolidation demonstrated across animal models.
- Enhanced acquisition through increased synaptic plasticity.
- Restoration in impairment models including scopolamine-induced amnesia.
neuroprotection
- Reduced amyloid burden in Alzheimer's models.
- Decreased neuroinflammation and glial activation.
- Protection of synapses in neurodegeneration models.
neuroplasticity
- 3-fold increase in dendritic spine formation demonstrated.
- Increases brain-derived neurotrophic factor expression.
- Promotes new blood vessel formation in brain.
Typical Dose
8-10mg oral or 2-5mg injectable (0.5mg/kg based on research)
Frequency
Once daily in the morning
Cycle Duration
4-8 weeks on
Storage
Oral: room temperature (2 year shelf life); Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C, use within 30 days
Chemical Makeup
Key benefits
Dramatic synaptogenesis promotion
10 million times more potent than BDNF
Cognitive enhancement and memory improvement
Neuroprotection and potential neuroregeneration
Applications for Alzheimer's, TBI, age-related cognitive decline
Oral bioavailability
Community interest
This peptide is still gaining traction in the community.
Synaptogenic Peptide | Cognitive Enhancement
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoDihexa Molecular Information
View the scientifc details of Dihexa.
2
Amino Acids
Dihexa
Tyr
Tyr
Position 1
Ile
Ile
Position 2
Molecular Weight
504.7DaChain Length
2Amino AcidsType
PeptideDihexa Protocols
Oral capsules/tablets are the most convenient form. Take in the morning with or without food. No reconstitution required.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard cognitive enhancement | 8 | 1 week range | Oral |
| Low-dose maintenance | 5 | 1 week range | Oral |
| Intensive learning protocol | 10 | 1 week range | Oral |
Dihexa Cycle
The Dihexa Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Subtle cognitive shifts; possible headaches during adaptation
- Week 2-4
- Improved focus and memory formation
- Week 4-8
- Peak cognitive benefits and enhanced learning
- Week 0-0
- Effects may persist for days to weeks after discontinuation
Dosing tools
Dihexa Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Dihexa
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Dihexa vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Dihexa
- Dosing
- 8-10mg oral or 2-5mg injectable (0.5mg/kg based on research)
- Dosing Frequency
- Once daily in the morning
- Cycle Duration
- 4-8 weeks on
- Storage
- Oral: room temperature (2 year shelf life); Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C, use within 30 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Dihexa interactions with other common peptides and substances.
Cognitive
cer
Longevity
Cerebrolysin
MONITOR
Both potently neuroactive; may cause overstimulation.
Cognitive
sel
Longevity
Selank
COMPATIBLE
Synergistic effects; watch for neural overstimulation.
Cognitive
sema
Longevity
Semax
COMPATIBLE
Enhanced cognitive benefits; monitor for overstimulation.
Side effects
Avoid: Do not take Dihexa with P21.
Monitor: Be careful when combining Dihexa with Cerebrolysin.
Contraindications
Not FDA approved - research compound only
Theoretical cancer risk via c-Met activation
Cancer history (avoid due to c-Met pathway)
Pregnancy or breastfeeding
No long-term human safety data
Stop signs
Severe or persistent headaches
Increasing anxiety or panic attacks
Significant mood changes or depression
Sleep disturbance beyond 3 days
Concerning neurological symptoms
Signs of overstimulation or mania
Injection site reactions (if injectable)
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
DihexaResearch References
Dihexa is an emerging compound
Dihexa
Dihexa is an emerging compound
Injectable Route Efficacy Study
Intraperitoneal injection at 0.5mg/kg/day completely reversed scopolamine-induced cognitive deficits (p<0.001), with performance indistinguishable from healthy controls.
2013
APP/PS1 Alzheimer's Model Study
Dihexa restored spatial learning and memory in Morris water maze tests, increased neuronal cells and synaptophysin expression, reduced neuroinflammation.
2021
Synaptogenic Potency Study
Demonstrated to be 10 million times more effective than BDNF at promoting synapse formation through HGF/c-Met receptor activation.
2014