Longevity
Glutathione
Immunity
3
Amino acids
Molecular weight
Peptide
Type
Glutathione is the body's master antioxidant, a tripeptide produced naturally by the liver. It protects cells against free radicals, peroxides, and heavy metals while eliminating toxins including drugs and pollutants. Injectable glutathione bypasses gastrointestinal breakdown for superior bioavailability compared to oral supplements. Research supports benefits for neurological health, immune function, skin health, and anti-aging.
Top researched benefits
Overview of Glutathione
Glutathione acts as the primary intracellular antioxidant, directly neutralizing reactive oxygen species and regenerating other antioxidants like vitamins C and E. It plays crucial roles in detoxification by conjugating with toxins for elimination, supports immune function through T-cell regulation, protects mitochondria, and maintains cellular redox balance. The thiol group of cysteine provides its antioxidant activity.
antioxidant and detox
- Primary cellular antioxidant that neutralizes free radicals and protects against oxidative damage.
- Binds and facilitates elimination of heavy metals and environmental toxins.
- Essential for hepatic detoxification pathways and liver protection.
neurological
- IV glutathione showed improvements in mental function and speech quality in case studies.
- Protects neurons against oxidative damage and supports brain health.
immune and skin
- Improved Th1 cytokines and immune markers in HIV patients with supplementation.
- Supports skin health with potential brightening effects through melanin modulation.
- Combats age-related oxidative stress and supports cellular longevity.
Typical Dose
100-600 mg injectable (100-200mg wellness, 200-600mg intensive); IV dosing higher (600-1400mg clinical)
Frequency
2-3 times weekly for subcutaneous; weekly
Cycle Duration
8-12 weeks
Storage
Lyophilized: 2-8°C refrigerated, protect from light; Reconstituted: 2-8°C refrigerated, protect from light
Chemical Makeup
Key benefits
Master antioxidant - protects against oxidative stress
Detoxification of heavy metals and toxins
Immune system support and T-cell function
Neuroprotective effects
Skin health and potential brightening effects
Liver protection and function
Mitochondrial support
Anti-aging properties
Community interest
This peptide is still gaining traction in the community.
L-Glutathione | Master Antioxidant Tripeptide
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoGlutathione Molecular Information
View the scientifc details of Glutathione.
3
Amino Acids
Glutathione
?
?
Position 1
Cys
Cys
Position 2
Gly
Gly
Position 3
Molecular Weight
307.33DaChain Length
3Amino AcidsType
PeptideGlutathione Protocols
Oral glutathione has poor bioavailability due to GI breakdown. Liposomal formulations may offer improved absorption but are still less effective than injection.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Daily supplementation | 250 | 1 week range | Oral |
Glutathione Cycle
The Glutathione Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Antioxidant activity begins
- Week 0-0
- Improved energy and well-being may be noticed
- Week 2-4
- Cumulative detoxification benefits
- Week 4-12
- Full benefits for skin, immunity, and cellular health
Dosing tools
Glutathione Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Glutathione
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Glutathione vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Glutathione
- Dosing
- 100-600 mg injectable (100-200mg wellness, 200-600mg intensive); IV dosing higher (600-1400mg clinical)
- Dosing Frequency
- 2-3 times weekly for subcutaneous; weekly
- Cycle Duration
- 8-12 weeks
- Storage
- Lyophilized: 2-8°C refrigerated, protect from light; Reconstituted: 2-8°C refrigerated, protect from light
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Glutathione interactions with other common peptides and substances.
Longevity
nad
Metabolic
NAD+
SYNERGISTIC
Both support cellular energy and antioxidant systems; commonly combined in longevity protocols.
Longevity
ss3
Metabolic
SS-31
SYNERGISTIC
Both protect mitochondria; different mechanisms complement each other.
Side effects
Contraindications
Known allergy to glutathione
Pregnancy or breastfeeding (insufficient safety data)
Asthma (may trigger bronchospasm in some)
Stop signs
Signs of allergic reaction (rash, difficulty breathing)
Severe abdominal pain
Signs of zinc deficiency
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
GlutathioneResearch References
Glutathione is an extensively studied compound
Glutathione
Glutathione is an extensively studied compound
IV Glutathione in Parkinson's Disease
IV glutathione 1,400 mg 3x weekly showed possible mild symptomatic effect in small trial.
n.d.
Liposomal Glutathione in HIV Patients
13-week supplementation improved Th1 cytokines including IL-12, IFN-γ, and TNF-α.
n.d.
Glutathione Supplementation for Skin Lightening
Narrative review of efficacy and safety for skin lightening applications.
n.d.
Glutathione Metabolism and Function
Comprehensive review of glutathione as master antioxidant and its roles in health.
n.d.