Cognitive
NA Semax Amidate
Longevity
9
Amino acids
Molecular weight
Peptide
Type
NA Semax Amidate (N-Acetyl Semax Amidate) is a synthetic heptapeptide derived from ACTH(4–10) with N-terminal acetylation and C-terminal amidation modifications that confer significantly enhanced metabolic stability over standard Semax. It stimulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) production and modulates serotonergic and dopaminergic signaling to support cognition and neuroprotection. Primarily used in research contexts for its nootropic and neuroprotective properties, it is approximately 3–4 times more potent per microgram than unmodified Semax.
Top researched benefits
Overview of NA Semax Amidate
NA Semax Amidate upregulates BDNF and its receptor TrkB in the hippocampus and modulates serotonin, dopamine, and enkephalin signaling pathways. The dual chemical modifications—N-acetyl cap and C-terminal amide—block enzymatic degradation from both ends of the peptide, extending plasma half-life and increasing CNS bioavailability relative to unmodified Semax.
cognitive
- Rapid improvement in sustained attention, working memory, and mental clarity within 15-30 minutes.
- Enhances both short-term and long-term memory consolidation through BDNF upregulation.
- Significant improvement in cognitive performance during mental fatigue, with lasting effects.
neuroprotection
- Accelerates functional recovery through enhanced neuroplasticity and BDNF elevation.
- Protects against neural oxidative damage and supports cellular repair mechanisms.
- Rapidly increases BDNF and TrkB receptor expression, supporting neuronal survival.
memory
- Improves episodic memory formation and recall through default mode network optimization.
- Enhances acquisition of new information through improved synaptic plasticity.
Typical Dose
600mcg per day (nasal) or 500–1000mcg per day (injectable)
Frequency
once daily
Cycle Duration
up to 8 weeks, followed by equal washout period
Storage
Lyophilized: -20°C for up to 1 year, protected from light and moisture. Reconstituted: 2–8°C for up to 30 days; avoid freeze-thaw cycles.
Chemical Makeup
Key benefits
Elevates BDNF and TrkB expression in the hippocampus, promoting synaptic plasticity and neurogenesis relevant to learning and memory
Provides neuroprotection in ischemic brain conditions by enhancing antihypoxic, angioprotective, and neurotrophic activity
Inhibits amyloid beta–copper ion complex formation and fibrillogenesis, potentially reducing neurodegeneration associated with Alzheimer's pathology
Modulates serotonergic and dopaminergic systems, supporting mood regulation and reduction of anxiety in research models
Community interest
This peptide is still gaining traction in the community.
BDNF/NGF Modulator | Cognitive Enhancement & Neuroprotection
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoNA Semax Amidate Molecular Information
View the scientifc details of NA Semax Amidate.
9
Amino Acids
NA Semax Amidate
Asn
Asn
Position 1
Ala
Ala
Position 2
Met
Met
Position 3
Glu
Glu
Position 4
His
His
Position 5
Phe
Phe
Position 6
Pro
Pro
Position 7
Gly
Gly
Position 8
Pro
Pro
Position 9
Molecular Weight
854.97DaChain Length
9Amino AcidsType
PeptideNA Semax Amidate Protocols
Intranasal administration is the primary and most clinically validated route for NA Semax Amidate, delivering the peptide directly via the olfactory pathway for rapid CNS access. The acetylation and amidation modifications provide enhanced enzymatic stability compared to native Semax, extending active duration to 4–8 hours per dose.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Cognitive enhancement (beginner) | 300 | 1 day range | Intranasal |
| Cognitive enhancement (standard) | 600 | 1 day range | Intranasal |
| Cognitive enhancement (advanced) | 900 | 1 day range | Intranasal |
| Mental fatigue and focus | 250 | 3 day range | Intranasal |
| Cognitive impairment recovery | 2000 | 4 day range | Intranasal |
| Stroke / neurological injury | 2500 | 4 day range | Intranasal |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clear nostrils by gently blowing before administration
- Disinfect the nozzle tip with an alcohol swab and allow it to dry
- Tilt head slightly backward to align the nasal passage
- Insert the nozzle into one nostril and spray while inhaling gently
- Wait 60 seconds before administering a second spray to the same nostril
- Repeat in the other nostril if a bilateral dose is required
- Avoid sneezing or blowing the nose for at least 5 minutes after administration
- Store the nasal spray bottle at 36–46°F (2–8°C) and protect from direct sunlight
NA Semax Amidate Cycle
The NA Semax Amidate Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Initial cognitive clarity and focus improvement
- Week 0-0
- Peak cognitive enhancement and mental alertness
- Week 0-0
- Sustained attention and memory benefits
- Week 0-0
- Gradual return to baseline with lasting effects
Dosing tools
NA Semax Amidate Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
NA Semax Amidate
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg NA Semax Amidate vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- NA Semax Amidate
- Dosing
- 600mcg per day (nasal) or 500–1000mcg per day (injectable)
- Dosing Frequency
- once daily
- Cycle Duration
- up to 8 weeks, followed by equal washout period
- Storage
- Lyophilized: -20°C for up to 1 year, protected from light and moisture. Reconstituted: 2–8°C for up to 30 days; avoid freeze-thaw cycles.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of NA Semax Amidate interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Different mechanisms with complementary neuroprotective benefits.
Side effects
Contraindications
Not recommended during pregnancy
Active nasal congestion or sinus infection
Individuals on neurotransmitter-affecting medications without consultation
Stop signs
Persistent nasal irritation, burning, or bleeding
Severe headaches or dizziness after administration
Unusual mood changes, anxiety, or agitation
Sleep disturbances or insomnia
Any allergic reactions (swelling, rash, difficulty breathing)
Significant changes in blood pressure or heart rate
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
NA Semax AmidateResearch References
NA Semax Amidate is a preclinical compound
NA Semax Amidate
NA Semax Amidate is a preclinical compound
Cognitive Enhancement in Fatigued Subjects
Improved attention and short-term memory in healthy subjects; 71% vs 41% memory accuracy with pronounced effects when fatigued.
1996
Default Mode Network Enhancement
24 subjects fMRI study. Significantly increased default mode network volume, particularly in medial frontal cortex, enhancing episodic memory.
2018
Stroke Recovery and BDNF Enhancement
110 participants. Increased brain-derived neurotrophic factor levels and accelerated functional recovery during rehabilitation.
2018
Gene Expression and Neuroprotection
Rat model revealed 96+ gene expression changes related to immune response, vascular function, and neuroprotection.
2014
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
