Cognitive Peptide Cheat Sheet

Selank is a synthetic heptapeptide derived from tuftsin with anxiolytic, nootropic, and immunomodulatory properties; it is most commonly administered as a nasal spray and is noted for reducing anxiety while enhancing focus and memory without sedation or dependence.

P21 is a synthetic peptide derived from CNTF (Ciliary Neurotrophic Factor) that promotes neurogenesis, BDNF expression, and cognitive function without the side effects associated with full-length CNTF. It is commonly used intranasally or via subcutaneous injection for memory enhancement and neuroprotection.

Pre-made solution at ~215 mg/mL (~1 g total); no reconstitution needed. Administer IM or slow IV. Cerebrolysin is a porcine brain-derived peptide mixture with neurotrophic and neuroprotective properties, clinically used for stroke, dementia, and TBI recovery. Biohackers use it for cognitive enhancement, neuroplasticity, and neuroprotection.

Cortagen is a short-chain peptide (Ala-Glu-Asp-Pro) developed by the St. Petersburg Institute of Bioregulation and Gerontology, designed to support brain and nervous system function by promoting neuronal protein synthesis and cognitive health. It is typically used in short courses to support memory, focus, and neuroprotection, and is part of the Khavinson peptide bioregulator class.

Blend of Selank, Semax, Pinealon, and PE-22-28 targeting mood, memory, focus, and neurogenesis. Nasal spray formulations need no BAC water; injectable versions use 1–2 mL. Frequency: daily or 5 on/2 off. Dose is product-dependent.

NA Semax Amidate is a modified, more potent and stable form of Semax featuring an N-acetyl group and C-terminal amidation, which increase bioavailability and resistance to enzymatic degradation. It is used primarily for cognitive enhancement, neuroprotection, BDNF upregulation, focus, and anxiety reduction, and is commonly administered subcutaneously or intranasally.

Pinealon is a tripeptide (Glu-Asp-Arg) derived from pineal gland tissue, studied for its neuroprotective and cognitive-enhancing effects. It is reported to improve memory, reduce oxidative stress in brain tissue, and support circadian rhythm regulation, often used in short cyclical courses.

Nasal spray; 0.1% or 1% solution — 2–3 drops per nostril per dose. Frequency: daily or 5 on/2 off. Semax is a synthetic heptapeptide derived from ACTH that increases BDNF and NGF expression, supporting memory, focus, and neuroprotection. Widely used in Russia as a prescription nootropic.

NA-Selank Amidate is a synthetic analog of the endogenous tetrapeptide tuftsin, modified with an N-acetyl group and amidated C-terminus to enhance stability and bioavailability; it is primarily used for anxiolytic effects, cognitive enhancement, and mood stabilization without sedation or dependence. It modulates the GABAergic and serotonergic systems and is popular among biohackers for reducing anxiety while improving focus and mental clarity.

PE-22-28 is a synthetic truncated analog of spadin, a peptide derived from the TREK-1 potassium channel antagonist, studied for its rapid antidepressant and neuroprotective effects. It is believed to work by blocking TREK-1 channels, promoting serotonin signaling and neurogenesis, making it of interest for depression, anxiety, and cognitive support.

Dihexa is a potent nootropic peptide derived from angiotensin IV that promotes synaptogenesis and enhances cognitive function, particularly memory and learning. It is typically administered orally or transdermally and is reported to be significantly more potent than BDNF at promoting new neural connections.

Regulates inflammation

Enhances deep sleep

Cell protective mitochondrial peptide

Improves nerve repair, reduces pain

Enhances bonding/intimacy