Cognitive
VIP
Immunity
3
Amino acids
Molecular weight
Peptide
Type
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. It is produced in many tissues including the gut, pancreas, and brain. VIP has potent vasodilatory, anti-inflammatory, and immunomodulatory effects. It binds to VPAC1 and VPAC2 receptors, triggering cAMP-mediated signaling cascades. Research shows therapeutic potential for pulmonary hypertension, diabetes, neurological disorders, and autoimmune conditions.
Top researched benefits
Overview of VIP
VIP binds to VPAC1 and VPAC2 G protein-coupled receptors, activating adenylyl cyclase and increasing intracellular cAMP and PKA activity. This triggers phosphorylation of CREB and other transcription factors. VIP causes vasodilation through NO-dependent and independent mechanisms, stimulates intestinal secretion, relaxes smooth muscle, inhibits gastric acid secretion, and has positive inotropic/chronotropic cardiac effects.
cardiovascular
- VIP inhalation shows striking efficacy with increased mixed venous oxygen saturation and exercise capacity.
- Dilates peripheral blood vessels through NO-dependent mechanisms above 100 pmol doses.
- Coronary vasodilation with positive inotropic and chronotropic effects on the heart.
neurological
- Promising therapeutic target for Alzheimer's, Parkinson's, and other neurological disorders.
- Potential therapeutic target being researched for ASD.
- Produced in suprachiasmatic nuclei; involved in circadian regulation.
metabolic and immune
- Promotes insulin secretion in glucose-dependent manner via VPAC2; low hypoglycemia risk.
- Potent anti-inflammatory effects useful in IBD and autoimmune conditions.
- Therapeutic potential for pulmonary and systemic sarcoidosis.
Typical Dose
50-100 mcg per dose (up to 200 mcg in research protocols)
Frequency
1-2 times daily due to very short 2-minute half-life
Cycle Duration
As prescribed for specific condition
Storage
Lyophilized powder: 2-8°C refrigerated; Reconstituted: use immediately (very short stability, ~2 minute half-life)
Chemical Makeup
Key benefits
Potent vasodilation and blood pressure reduction
Strong anti-inflammatory effects
Immunomodulation (Th1-Th2 balance)
Neuroprotective effects
Bronchodilation
Cardioprotective (positive inotropic effects)
Insulin secretion enhancement (glucose-dependent)
Gut barrier and permeability regulation
Community interest
This peptide is still gaining traction in the community.
Vasoactive Intestinal Peptide | Neuropeptide
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoVIP Molecular Information
View the scientifc details of VIP.
3
Amino Acids
VIP
His
His
Position 1
Trp
Trp
Position 2
Arg
Arg
Position 3
Molecular Weight
497.6DaChain Length
3Amino AcidsType
PeptideVIP Protocols
VIP has a very short half-life of approximately 2 minutes in blood, requiring careful dosing strategies. Subcutaneous or intravenous administration. Rapid degradation limits bioavailability; analogs like stearyl-Nle17-VIP (SNV) are 100-fold more potent.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| General use | 50 | 1 week range | SubQ or IV |
| Research protocols | 100 | — | SubQ or IV |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clean work area and hands thoroughly
- Calculate required BAC water volume
- Draw BAC water into syringe
- Inject slowly down vial side
- Gently swirl until dissolved (never shake)
- Use promptly due to short stability
VIP Cycle
The VIP Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Rapid vasodilation and hemodynamic effects
- Week 0-0
- Anti-inflammatory signaling activated
- Week 0-0
- Cumulative effects on inflammation and immune balance
- Week 0-0
- Sustained benefits with regular administration
Dosing tools
VIP Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
VIP
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg VIP vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- VIP
- Dosing
- 50-100 mcg per dose (up to 200 mcg in research protocols)
- Dosing Frequency
- 1-2 times daily due to very short 2-minute half-life
- Cycle Duration
- As prescribed for specific condition
- Storage
- Lyophilized powder: 2-8°C refrigerated; Reconstituted: use immediately (very short stability, ~2 minute half-life)
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of VIP interactions with other common peptides and substances.
Side effects
Contraindications
Severe hypotension
VIPoma or related tumors
Pregnancy or breastfeeding
Severe cardiac conditions
Stop signs
Severe hypotension
Allergic reaction symptoms
Severe diarrhea
Cardiac arrhythmias
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
VIPResearch References
VIP is an extensively studied compound
VIP
VIP is an extensively studied compound
VIP as New Drug for Treatment of Primary Pulmonary Hypertension
VIP inhalation showed striking efficacy with increased mixed venous oxygen saturation and exercise capacity.
n.d.
Therapeutic Potential of VIP and VPAC2 in Type 2 Diabetes
VIP promotes glucose-dependent insulin secretion via VPAC2, reducing hypoglycemia risk.
n.d.
Therapeutic Potential of VIP in Neurological Disorders
VIP and receptors are promising therapeutic targets for AD, PD, and autism spectrum disorders.
n.d.
VIP Structure and Function for Therapeutic Applications
Comprehensive review of VIP receptor signaling and therapeutic applications.
n.d.