TB-500 (Ac-LKKTETQ)

FDA APPROVAL PENDING

Moderate Research

Healing

Longevity

Healing

TB-500 (Ac-LKKTETQ)

Longevity

Amino acid sequence

7

Amino acids

889da

Molecular weight

Peptide

Type

TB-500 (Ac-LKKTETQ) is a synthetic derivative of thymosin beta-4 consisting of the N-terminal acetylated 17-23 amino acid fragment. This sequence represents the active site within thymosin beta-4 responsible for actin binding, cell migration, and wound healing. Research shows it promotes endothelial cell differentiation, angiogenesis, keratinocyte migration, collagen deposition, and decreases inflammation. The acetylation protects against N-terminal degradation while maintaining biological activity.

Top researched benefits

Overview of TB-500 (Ac-LKKTETQ)

TB-500 contains the LKKTETQ sequence which is the actin-binding motif of full-length thymosin beta-4. This fragment shares many properties of the parent protein regarding cell proliferation, differentiation, and migration. It promotes angiogenesis by upregulating VEGF expression and enhancing endothelial cell sprouting. The peptide undergoes serial cleavage at the C-terminus during metabolism, while the N-terminal acetylation provides protection from degradation.

Tissue Repair

  • Promotes dermal wound healing through the active LKKTETQ sequence.
  • Supports tissue repair comparable to full thymosin beta-4 in research.
  • Promotes keratinocyte migration and collagen deposition.

Vascular Support

  • Promotes endothelial cell differentiation and new blood vessel formation.

Antiinflammatory

  • Decreases inflammatory responses in damaged tissues.

Storage

Reconstituted: 2-8°C refrigerated

Frequency

2x weekly (e.g., Monday and Thursday)

Typical Dose

2-2.5mg per injection

Cycle Duration

4-6 weeks loading phase

Chemical Makeup

Key benefits

Promotes wound healing

Enhances cell migration

Supports angiogenesis (new blood vessel formation)

Reduces inflammation

Promotes keratinocyte migration

Supports collagen deposition

Enhances tissue repair

Active region of thymosin beta-4

Community interest

This peptide is still gaining traction in the community.

Thymosin Beta-4 Active Fragment | Healing Peptide

This overview is informational and based on aggregated descriptions from studies and user reports.

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TB-500 (Ac-LKKTETQ) Molecular Information

View the scientifc details of TB-500 (Ac-LKKTETQ).

7

Amino Acids

TB-500 (Ac-LKKTETQ)

Leu

Leu

Position 1

Lys

Lys

Position 2

Lys

Lys

Position 3

Thr

Thr

Position 4

Glu

Glu

Position 5

Thr

Thr

Position 6

Gln

Gln

Position 7

Amino acid sequence
LeucinePosition 1
LysinePosition 2
LysinePosition 3
ThreoninePosition 4
Glutamic acidPosition 5
ThreoninePosition 6
GlutaminePosition 7

Molecular Weight

889Da

Chain Length

7Amino Acids

Type

Peptide

TB-500 (Ac-LKKTETQ) Protocols

TB-500 is typically administered via subcutaneous injection. The N-terminal acetylation provides stability and protection from degradation. Not authorized for medicinal use; research peptide only.

GoalDosageFrequencyRoute
Loading phase22 week rangeSubQ
Maintenance2—SubQ

Reconstitution Instructions

Materials needed:

Bacteriostatic waterInsulin syringesAlcohol swabsPeptide vialSterile work surface

Steps to reconstitute

  1. Clean work area and hands thoroughly
  2. Calculate required BAC water volume
  3. Draw BAC water into syringe
  4. Inject slowly down vial side
  5. Gently swirl until dissolved (never shake)
  6. Store reconstituted solution refrigerated

TB-500 (Ac-LKKTETQ) Cycle

The TB-500 (Ac-LKKTETQ) Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.

Taking breaks between cycles may help maintain effectiveness and support better overall results.

Day 1-7
Initial wound healing acceleration
Week 1-2
Enhanced cell migration and angiogenesis
Week 2-4
Visible tissue repair improvements
Week 4-6
Full healing benefits; transition to maintenance

Dosing tools

TB-500 (Ac-LKKTETQ) Peptide Dosage Calculator

Calculate peptide doses with our visual syringe guide.

0.3mL / 30 units

5 units

0.050 mL

1 mL

2 mL

3 mL

5 mL

Custom

Conversion: 1,000 mcg = 1 mg

Injection Results

Based on your vial and dilution inputs.

Safe concentration range

TB-500 (Ac-LKKTETQ)

SINGLE COMPOUND

Volume per injection

0.05

mL

Concentration

10.00

mg/mL

Doses per vial

20

doses

Total injections per vial

20 injections

How it works

Based on a 10 mg TB-500 (Ac-LKKTETQ) vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.

Research Purposes Only

These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.

Reference Guide

Dosing Cycle

Peptide
TB-500 (Ac-LKKTETQ)
Dosing
2-2.5mg per injection
Dosing Frequency
2x weekly (e.g., Monday and Thursday)
Cycle Duration
4-6 weeks loading phase
Storage
Reconstituted: 2-8°C refrigerated

Note: Triple agonist; microdose for fewer side effects

Reconstitution Tips

  • Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
  • Inject water slowly — aim down the vial wall, not directly onto powder
  • Never shake — gently swirl or roll the vial until dissolved
  • Store properly — refrigerate at 2-8°C after reconstitution
  • Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
  • Keep sterile — always clean vial tops with alcohol before drawing

Peptide Interactions

Research suggestions of TB-500 (Ac-LKKTETQ) interactions with other common peptides and substances.

Healing

bpc

Longevity

BPC-157

SYNERGISTIC

Commonly combined for enhanced healing effects through different mechanisms.

SYNERGISTIC

Healing

ghk

Longevity

GHK-Cu

SYNERGISTIC

Both support wound healing and tissue repair through different pathways.

SYNERGISTIC

Growth

igf

Healing

IGF-1 LR3

COMPATIBLE

Different mechanisms; may complement for tissue growth.

COMPATIBLE

Healing

thymos

Longevity

Thymosin Beta-4

COMPATIBLE

TB-500 is the active fragment; combining may be redundant.

COMPATIBLE

Side effects

Contraindications

Not authorized for medicinal use

Active cancer (theoretical concern)

Pregnancy or breastfeeding

Prohibited by WADA in sports

Stop signs

Allergic reactions

Unusual swelling or inflammation

Bad signs

DiscolorationCloudy solutionParticulates visible
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Frequently asked questions

What benefits can peptides offer in research?

Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.

What are some exciting applications of peptides in modern science?

Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.

How do peptides influence health and wellness?

Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.

Where can I find the latest studies on peptide applications?

Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.

Are there any guidelines for using peptides in research?

Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.

What is the difference between peptides and proteins?

Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.

How should peptides be stored?

Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.

Can peptides be taken orally?

Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.

TB-500 (Ac-LKKTETQ)Research References

TB-500 (Ac-LKKTETQ) is a moderate research compound

4Research references

TB-500 (Ac-LKKTETQ)

TB-500 (Ac-LKKTETQ) is a moderate research compound

Synthesis and Characterization of N-terminal Acetylated 17-23 Fragment of Thymosin Beta-4

TB-500 contains Ac-LKKTETQ, the active site responsible for actin binding and wound healing.

n.d.

Doping Control Analysis of TB-500

TB-500 is a synthetic version of the active region of thymosin beta-4.

n.d.

TB-500 Metabolism and Wound Healing

TB-500 undergoes serial cleavage at C-terminus; acetylation protects N-terminus.

n.d.

Investigation of TB-500 Metabolism

Characterized human metabolism of TB-500 using liver microsomes and S9 fraction.

n.d.