Growth
IGF-1 LR3
Healing
0
Amino acids
Molecular weight
Peptide
Type
IGF-1 LR3 is a synthetic 83-amino acid analog of insulin-like growth factor-1 that has never been approved for human use. The N-terminal extension and R3 substitution reduce binding protein interaction, maintaining elevated free circulating levels with ~3x greater potency than native IGF-1.
Top researched benefits
Overview of IGF-1 LR3
Functions as a full IGF-1 receptor agonist activating PI3K/Akt/mTOR and MAPK/ERK pathways. The modifications prevent protein sequestration, maintaining elevated free circulating levels for extended anabolic effects.
muscle growth
- 15-20% lean mass gains in 4 weeks through satellite cell activation (rat studies).
- Cancer cachexia rats maintained 30% more muscle versus placebo.
- Creates new muscle fibers via satellite cell differentiation.
tissue repair
- Accelerated wound healing in animal models.
- Enhanced connective tissue repair.
metabolic
- Directs nutrients toward muscle tissue.
- Enhanced lipolysis through IGF-1 pathway.
Typical Dose
20-100 mcg daily (start low at 20-30 mcg)
Frequency
Once daily, or split AM/PM for higher doses
Cycle Duration
4-6 weeks maximum
Storage
Lyophilized: -20°C to -80°C. Reconstituted in acetic acid: 2-8°C for 1 year. Reconstituted in BAC water: use within 7 days
No visual available
Due to this peptide having no amino acids, there is no molecular chain to display.
Chemical Makeup
Key benefits
Approximately 3x more potent than native IGF-1
Promotes muscle hypertrophy and hyperplasia in animal models
15-20% lean mass gains observed in 4-week rat studies
Anti-catabolic effects preserve muscle during cachexia
20-30 hour half-life for sustained effects
Community interest
This peptide is still gaining traction in the community.
Modified Growth Factor Analog | Muscle Growth
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoIGF-1 LR3 Protocols
Subcutaneous or intramuscular injection. CRITICAL: Consume 30-60g fast carbohydrates immediately after injection to prevent hypoglycemia. Never inject before sleep.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Beginner Protocol | 20 | 1 week range | SubQ/IM |
| Intermediate | 40 | 1 week range | SubQ/IM |
| Advanced | 80 | 1 week range | SubQ/IM |
| Women's Protocol | 10 | 1 week range | SubQ/IM |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Equilibrate to room temperature (15-30 min)
- Sanitize rubber stopper with alcohol
- Calculate concentration (e.g., 1mg in 2mL = 500mcg/mL)
- Inject diluent slowly along vial wall
- Gently swirl - never shake vigorously
- Allow 2-5 minutes for complete dissolution
- Store immediately at 2-8°C protected from light
- Acetic acid reconstitution: stable 1 year
- BAC water reconstitution: use within 7 days
IGF-1 LR3 Cycle
The IGF-1 LR3 Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Increased muscle pump and fullness; possible hypoglycemia if carbs inadequate
- Week 2-4
- Enhanced recovery, strength gains, visible fullness, potential water retention
- Week 4-6
- Maximum effects; receptor desensitization approaching; joint stiffness common
- Week 0-0
- Pump loss over 1-2 weeks; strength/size gains may persist with training
Dosing tools
IGF-1 LR3 Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
IGF-1 LR3
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg IGF-1 LR3 vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- IGF-1 LR3
- Dosing
- 20-100 mcg daily (start low at 20-30 mcg)
- Dosing Frequency
- Once daily, or split AM/PM for higher doses
- Cycle Duration
- 4-6 weeks maximum
- Storage
- Lyophilized: -20°C to -80°C. Reconstituted in acetic acid: 2-8°C for 1 year. Reconstituted in BAC water: use within 7 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of IGF-1 LR3 interactions with other common peptides and substances.
Side effects
Monitor: Be careful when combining IGF-1 LR3 with Cerebrolysin, MK-677.
Contraindications
NEVER approved for human use - research chemical only
Cancer history or undiagnosed growths
May cause organ hypertrophy (heart, intestines)
WADA prohibited - causes failed drug tests
Stop signs
Severe or recurring hypoglycemia despite carbohydrate intake
Unusual growths, lumps, or rapid mole changes
Severe joint pain or carpal tunnel symptoms
Persistent nausea, headaches, or vision changes
Signs of organ enlargement
Extreme fatigue or mental fog
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
IGF-1 LR3Research References
IGF-1 LR3 is a limited compound
IGF-1 LR3
IGF-1 LR3 is a limited compound
Rat Muscle Hypertrophy Study - Florini et al.
2.5mg/kg/day for 4 weeks showed 2.5x greater anabolic response compared to native IGF-1. Satellite cell activation and protein synthesis increased 50%.
1996
Fetal Sheep Metabolic Study
Acute infusion suppressed insulin secretion by 66%. Study halted early due to 4 animal deaths from hypoglycemia.
2000
Cancer Cachexia Rat Model
0.3mg/kg/day for 14 days showed 30% lean mass preservation during cachexia.
1998
UK Biobank Cancer Association
Elevated IGF-1 associated with multiple cancers including thyroid, colorectal, breast, prostate, melanoma.
2023