Reviewed by the PeptideMind Team · Updated July 15, 2026

Ara 290 Dosage Guide, Benefits & Side Effects

ARA-290 (Cibinetide) regenerates small nerve fibers and eases neuropathic pain by calming inflammation. See Phase 2 trial data and dosing.

Chemical Makeup

11

Amino Acids

Ara 290

?

X

Position 1

Glu

E

Position 2

Gln

Q

Position 3

Leu

L

Position 4

Glu

E

Position 5

Arg

R

Position 6

Ala

A

Position 7

Leu

L

Position 8

Asn

N

Position 9

Ser

S

Position 10

Ser

S

Position 11

Amino acid sequence
?Position 1
Glutamic acidPosition 2
GlutaminePosition 3
LeucinePosition 4
Glutamic acidPosition 5
ArgininePosition 6
AlaninePosition 7
LeucinePosition 8
AsparaginePosition 9
SerinePosition 10
SerinePosition 11

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Ara 290 Dosage Guide for Recovery & Repair

Ara 290 may help repair nerves and reduce pain.

Vial size

5 mg

Bacteriostatic water

2 mL

Dosing

4 mg

Frequency

Daily

Cycle

4–12 weeks

Benefit

Recovery & Repair

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What is Ara 290?

ARA 290 (also called Cibinetide) is a small, lab-made peptide based on part of the hormone erythropoietin (EPO), but modified so it doesn't affect red blood cells the way EPO does. Instead, it targets a repair pathway in the body that can help heal damaged nerves and calm inflammation. It's being studied mainly for nerve pain conditions and inflammatory disorders, and has shown promising results in human studies.

Healing

Research targets include tissue repair, wound healing, and recovery from injury.

Cognitive

Research targets include neural signaling, memory formation, and mental clarity pathways.

Healing

ara

Cognitive

Is Ara 290 FDA approved?

Ara 290 is not an FDA-approved drug. It is intended for research purposes only and is not approved for human consumption, diagnostic, or therapeutic use.

Research Use Only

Ara 290 has not been evaluated by the FDA for safety or efficacy in humans.

No Clinical Oversight

Not manufactured under FDA-regulated quality or clinical standards.

Unregulated Sourcing

Purity, dosing, and sourcing are not verified through FDA testing or oversight.

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How Does Ara 290 Work?

It locks onto a repair-signaling receptor found on damaged tissue, calming inflammatory alarm systems inside cells and dialing down inflammation-triggering proteins. That same signal also encourages damaged small nerve fibers to regrow.

Binds a repair receptor

Locks onto a signaling receptor found on damaged tissue.

Calms inflammation

Dials down inflammatory alarm systems inside cells.

Helps nerves regrow

Encourages damaged small nerve fibers to regenerate.

Ara 290 Targeted areas

How to reconstitute Ara 290

View guide

The materials you'll need and step-by-step instructions for safely mixing Ara 290 with bacteriostatic water.

Materials needed

Your Ara 290 vial (lyophilized)

Alcohol swabs

Bacteriostatic sterile water

3 mL syringes (Luer Lock tip)

25G or 27G needles (Luer Lock). Other gauges may also be acceptable.

Sharps container (optional)

1

Remove the caps

Remove the caps from both your Ara 290 vial and your bacteriostatic water vial.
2

Sanitize the rubber stoppers

Wipe down the rubber stoppers on both vials with alcohol swabs and let them dry for about 3 minutes.
3

Attach the needle

Take your 3 mL syringe and needle. Twist the needle's plastic hub into the Luer Lock tip on the syringe to secure it.
4

Draw the bac water

Pull back on the plunger to draw your desired volume of bacteriostatic water. If you overfill, just push the excess back in until you reach the right marker on the syringe.

How much bac water? Ara 290 typically comes in a 5 mg vial. We recommend 2 mL of bacteriostatic water, though anywhere between 1 mL and 3 mL is acceptable. For larger vials you can use up to 5 mL — more bac water makes microdosing easier, but insulin needles usually max out at 1 mL per injection. That means a lot of bac water might force you into multiple injections to hit your target dose. Unless you're microdosing, 2 mL per vial is a solid rule of thumb.
5

Insert the needle into the Ara 290 vial

With the bac water in your syringe, insert the needle into the Ara 290 vial at a slight angle to avoid pressure buildup.

Use a thin needle: Stick to 25G or higher to avoid damaging the rubber stopper. Higher gauge means a thinner needle.
6

Release the water gently

Let the water run gently down the side of the vial. Don't inject it forcefully.

Heads up: Sometimes the plunger pushes itself in as soon as the needle enters the vial. Hold the plunger back so you have full control over how fast the bac water enters.
7

Swirl to dissolve

Avoid shaking. Gently swirl, flip, and roll the vial to dissolve the powder.

Be patient: This usually takes 2 to 5 minutes of consistent swirling, mixing in a circular motion, and gently flipping the vial up and down. The water needs to run through the powder many times to fully dissolve it. Don't shake or get aggressive with it.
8

Check for full dissolution

The solution should be clear with no visible particles. If it's cloudy or clumpy, wait a minute and repeat the swirling step.
9

Cap, dispose, and store

Once you're done, cap the needle and dispose of it (ideally in a sharps container). Store the reconstituted Ara 290 vial in the fridge whenever it's not in use. It will stay good for approximately 30 days.

How to Store Ara 290

The dry powder lasts up to two years in the fridge or three years in the freezer, kept away from light. Once mixed with liquid, refrigerate and use within about a month, and never freeze it again.

Lyophilized Storage

2–8°C for up to 2 years, or -20°C for up to 3 years, protected from light.

Reconstituted Storage

2–8°C, use within 28 days; do not freeze.

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What Are the Benefits of Ara 290?

What research says it may help with, and how it works in the body.

neuroprotection

Increased the area of nerve fibers in the cornea (eye surface) by 23%, along with lasting improvement in pain.

Able to pass into the brain (crossing the blood-brain barrier) to help protect brain cells after stroke or traumatic brain injury.

Helped nerves regenerate and improved metabolic measures in people with Type 2 diabetes.

tissue repair

Speeds up skin healing (regrowth of the outer skin layer) and new blood vessel formation by increasing a growth factor called VEGF.

Helped preserve heart function in aging studies.

In heart attack studies, it reduced the amount of heart tissue damaged.

antiinflammatory

Reduced the severity of colon inflammation (colitis) in animal studies.

Helps transplanted tissue survive longer and lowers the chance of the body rejecting it.

Lowers production of several inflammation-triggering substances in the body (TNF-alpha, IL-6, and IL-12).

What Are the Side Effects of Ara 290?

Who should avoid it, warning signs to watch for, and what to know before combining it with other compounds.

Who Should Avoid It

Recent anti-TNF therapy (within 6 months)

EPO use (within 2 months)

Pregnancy

BMI > 34 kg/m²

Stop Right Away If You Notice

Severe injection site reactions

Unexpected blood count changes

Allergic reaction signs

Worsening of underlying condition

New neurological symptoms

Any serious adverse events

Milder Signs to Watch For

Cloudy or discolored solution indicates degradation; should be clear to slightly cloudy
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How Long Should a Ara 290 Cycle Last?

This breaks down how long a typical Ara 290 cycle runs and what research suggests happens at each stage. Research shows that staying on a peptide continuously, without a break, may make it less effective over time.

That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again.

Week 1-2
Initial anti-inflammatory effects and mild pain symptom improvement
Week 2-4
Progressive nerve regeneration, improved tissue healing markers
Week 4-6
Peak therapeutic effects, maximum nerve fiber density improvements
Month 2-6
Long-lasting benefits via molecular switch effect

Cheat Sheets Featuring Ara 290

See how Ara 290 fits into a broader research stack with these free downloadable cheat sheets. Each one includes reference dose ranges, dosing frequency, and half-life for every peptide it covers. For research purposes only.

View all
Cognitive Peptide Cheat Sheet
Cognitive Peptide Cheat Sheet

16 peptides

Healing & Recovery Peptide Cheat Sheet
Healing & Recovery Peptide Cheat Sheet

18 peptides

Master Peptide Cheat Sheet
Master Peptide Cheat Sheet

78 peptides

Ara 290 Research References

It is a phase 2 compound

5Research references

Ara 290

Ara 290 is a phase 2 compound

Sarcoidosis Neuropathy Phase 2b Trial

64 patients, 1-8 mg SC daily for 28 days: 23% increase in corneal nerve fiber area at 4 mg dose.

2017

Diabetic Macular Edema Pilot Study

9 patients, 4 mg SC daily for 12 weeks: Improved quality of life; good safety profile.

2020

Myocardial Infarction Protection Study

Preclinical mouse model, 24 μg/kg IV single dose: Reduced infarct size and improved survival.

2012

Stroke Neuroprotection Research

Rat stroke model, 300 μg/kg IV single dose: Reduced stroke volume; BBB penetration confirmed.

2011

Type 2 Diabetes Neuropathy Phase 2

48 patients, 4 mg SC daily for 28 days: Sustained HbA1c improvement and nerve regeneration.

2015

Frequently Asked Questions About Ara 290

Straight answers on reconstitution, dosing, and safety, everything you need to research with confidence. For research reference only.