Healing
Ara 290
Cognitive
11
Amino acids
Molecular weight
Peptide
Type
Ara 290 is an engineered 11-amino acid peptide activating the Innate Repair Receptor (IRR) to provide tissue-protective effects without red blood cell stimulation. Has FDA Orphan Drug status.
Top researched benefits
Overview of Ara 290
Activates IRR through EPOR/β-common receptor complex, triggering tissue-protective signaling without erythropoietic effects.
Neuroprotection
- 23% increase in corneal nerve fiber area with sustained pain improvement.
- Nerve regeneration and metabolic improvements in Type 2 diabetes patients.
- Crosses blood-brain barrier for stroke and TBI neuroprotection.
Tissue Repair
- Improves epithelialization and angiogenesis via VEGF upregulation.
- Reduces infarct size in myocardial infarction models.
- Maintains cardiac function in aging models.
Antiinflammatory
- Reduces TNF-α, IL-6, and IL-12 production.
- Reduces colitis severity in animal models.
- Improves graft survival and reduces rejection.
Storage
Lyophilized: 2-8°C refrigerated, protect from light. Reconstituted: use immediately or refrigerate up to 24 hours
Frequency
Once daily
Typical Dose
4 mg daily
Cycle Duration
28 days
Chemical Makeup
Key benefits
Proven tissue protection
Nerve regeneration
Anti-inflammatory effects
Excellent safety profile in clinical trials
Community interest
This peptide is still gaining traction in the community.
Tissue-Protective Peptide | Innate Repair Receptor Agonist
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesAra 290 Molecular Information
View the scientifc details of Ara 290.
11
Amino Acids
Ara 290
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?
Position 1
Glu
Glu
Position 2
Gln
Gln
Position 3
Leu
Leu
Position 4
Glu
Glu
Position 5
Arg
Arg
Position 6
Ala
Ala
Position 7
Leu
Leu
Position 8
Asn
Asn
Position 9
Ser
Ser
Position 10
Ser
Ser
Position 11
Molecular Weight
1257.3DaChain Length
11Amino AcidsType
PeptideAra 290 Protocols
Primary clinical administration route with proven efficacy.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Neuropathy Treatment | 4 | 1 week range | SubQ |
| Tissue Protection | 1 | 1 week range | SubQ |
| Acute Intervention | 2 | 3 week range | IV |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Allow vial to reach room temperature (15-20 minutes)
- Clean vial top with alcohol swab
- Slowly inject 1 mL sterile water
- Gently swirl to dissolve (no vigorous shaking)
- Slight cloudiness is normal
- Use immediately or refrigerate up to 24 hours
- Protect from light
- Rotate injection sites
Ara 290 Cycle
The Ara 290 Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- Initial anti-inflammatory effects and mild pain symptom improvement
- Week 2-4
- Progressive nerve regeneration, improved tissue healing markers
- Week 4-6
- Peak therapeutic effects, maximum nerve fiber density improvements
- Month 2-6
- Long-lasting benefits via molecular switch effect
Dosing tools
Ara 290 Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
Ara 290
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Ara 290 vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- Ara 290
- Dosing
- 4 mg daily
- Dosing Frequency
- Once daily
- Cycle Duration
- 28 days
- Storage
- Lyophilized: 2-8°C refrigerated, protect from light. Reconstituted: use immediately or refrigerate up to 24 hours
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Ara 290 interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
SYNERGISTIC
Complementary tissue repair pathways may enhance wound healing.
Longevity
nad
Metabolic
NAD+
MONITOR
Both affect cellular metabolism; monitor for additive effects.
Weight
sem
Metabolic
Semaglutide
COMPATIBLE
No adverse interactions in clinical trials with GLP-1 agonists.
Healing
thymos
Longevity
Thymosin Beta-4
COMPATIBLE
No known interactions; different mechanisms for tissue protection.
Side effects
Monitor: Be careful when combining Ara 290 with NAD+.
Contraindications
Recent anti-TNF therapy (within 6 months)
EPO use (within 2 months)
Pregnancy
BMI > 34 kg/m²
Stop signs
Severe injection site reactions
Unexpected blood count changes
Allergic reaction signs
Worsening of underlying condition
New neurological symptoms
Any serious adverse events
Bad signs
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Frequently asked questions
What benefits can peptides offer in research?
Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.
What are some exciting applications of peptides in modern science?
Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.
How do peptides influence health and wellness?
Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.
Where can I find the latest studies on peptide applications?
Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.
Are there any guidelines for using peptides in research?
Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.
What is the difference between peptides and proteins?
Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.
How should peptides be stored?
Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.
Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
Ara 290Research References
Ara 290 is an extensively studied compound
Ara 290
Ara 290 is an extensively studied compound
Sarcoidosis Neuropathy Phase 2b Trial
64 patients, 1-8 mg SC daily for 28 days: 23% increase in corneal nerve fiber area at 4 mg dose.
2017
Type 2 Diabetes Neuropathy Phase 2
48 patients, 4 mg SC daily for 28 days: Sustained HbA1c improvement and nerve regeneration.
2015
Diabetic Macular Edema Pilot Study
9 patients, 4 mg SC daily for 12 weeks: Improved quality of life; good safety profile.
2020
Myocardial Infarction Protection Study
Preclinical mouse model, 24 μg/kg IV single dose: Reduced infarct size and improved survival.
2012
Stroke Neuroprotection Research
Rat stroke model, 300 μg/kg IV single dose: Reduced stroke volume; BBB penetration confirmed.
2011