Longevity
Epitalon
Immunity
4
Amino acids
Molecular weight
Peptide
Type
Epitalon is a synthetic tetrapeptide developed by Russian scientist Vladimir Khavinson with 35+ years of research. It activates telomerase at extremely low concentrations to maintain telomere length, stimulates melatonin production, and modulates gene expression through epigenetic mechanisms.
Top researched benefits
Overview of Epitalon
Activates telomerase at extremely low concentrations (10⁻¹⁷ to 10⁻¹⁵ M) to maintain telomere length, stimulates melatonin production from the pineal gland, and modulates gene expression through epigenetic mechanisms.
Antiaging
- Activates telomerase at microgram doses to extend telomeres and cellular replicative lifespan.
- Reverses aging markers and improves mitochondrial function at the cellular level.
- Animal studies show 25-33% lifespan increases using 30-40mcg/kg doses.
Neuroprotection
- Restores pineal gland function and circadian melatonin rhythm in elderly.
- Supports new neuron formation at nanogram concentrations.
- 90% response rate for retinal degeneration at 5mcg per eye dosing.
Immunity
- Supports thymus gland regeneration for improved immune function.
- Enhanced immune surveillance and countering of immunosenescence.
Storage
Lyophilized: 2-8°C refrigerated; Reconstituted: 2-8°C refrigerated, use within 30 days
Frequency
Once daily for 10-20 consecutive days
Typical Dose
100-500mcg per injection
Cycle Duration
10-20 days per cycle
Chemical Makeup
Key benefits
Telomere extension and cellular replicative lifespan extension
Enhanced melatonin production
Improved immune function
Potential lifespan extension (25-33% in animal studies)
Systemic anti-aging through cellular rejuvenation
Short cycle duration with long-lasting effects
Community interest
This peptide is still gaining traction in the community.
Synthetic Pineal Tetrapeptide | Telomerase Activator
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesEpitalon Molecular Information
View the scientifc details of Epitalon.
4
Amino Acids
Epitalon
Ala
Ala
Position 1
Glu
Glu
Position 2
Asp
Asp
Position 3
Gly
Gly
Position 4
Molecular Weight
390.35DaChain Length
4Amino AcidsType
PeptideEpitalon Protocols
Subcutaneous injection is the primary and most researched route. Short cycles of 10-20 days with 4-6 month breaks between cycles.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard anti-aging | 200 | 1 week range | SubQ |
| Conservative start | 100 | 1 week range | SubQ |
| Russian clinical equivalent | 300 | 1 week range | SubQ |
| Ultra-low dose | 50 | 1 week range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clean vial tops with alcohol swabs
- Add 5mL bacteriostatic water to 10mg vial (creates 2mg/mL)
- Inject water slowly at vial side wall
- Gently swirl - do not shake vigorously
- Solution should be clear and colorless
- Refrigerate immediately
- Use 0.3mL insulin syringes for accurate microgram dosing
- Use within 30 days of reconstitution
Epitalon Cycle
The Epitalon Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- Subtle energy improvement possible
- Day 3-7
- Better sleep quality, vivid dreams (melatonin effect)
- Week 0-0
- Enhanced morning energy, mood stability
- Week 3-4
- Skin quality improvements, enhanced wound healing
- Month 2-3
- Laboratory markers may show telomere changes
- Week 0-0
- Cumulative anti-aging benefits with repeated cycles
Dosing tools
Epitalon Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
Epitalon
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Epitalon vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- Epitalon
- Dosing
- 100-500mcg per injection
- Dosing Frequency
- Once daily for 10-20 consecutive days
- Cycle Duration
- 10-20 days per cycle
- Storage
- Lyophilized: 2-8°C refrigerated; Reconstituted: 2-8°C refrigerated, use within 30 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Epitalon interactions with other common peptides and substances.
Longevity
thy
Immunity
Thymalin
SYNERGISTIC
Enhanced immunomodulation - commonly combined in Russian protocols.
Side effects
Contraindications
Active malignancy (telomerase activation concern)
Chronic sinusitis (nasal route)
Known peptide allergies
Pregnancy or breastfeeding
Stop signs
Signs of allergic reaction
Persistent injection site inflammation
New or changing moles (monitor skin)
Cancer diagnosis (discontinue immediately)
Unusual fatigue or weakness
Bad signs
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Frequently asked questions
What benefits can peptides offer in research?
Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.
What are some exciting applications of peptides in modern science?
Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.
How do peptides influence health and wellness?
Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.
Where can I find the latest studies on peptide applications?
Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.
Are there any guidelines for using peptides in research?
Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.
What is the difference between peptides and proteins?
Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.
How should peptides be stored?
Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.
Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
EpitalonResearch References
Epitalon is a well studied compound
Epitalon
Epitalon is a well studied compound
Telomerase Activation Study
Human fibroblasts showed extended replicative lifespan (34→44+ passages) at 0.1μM concentration while maintaining telomere length comparable to young cells.
2003
Russian Clinical Trials
Long-term observations showed significantly lower all-cause mortality in elderly subjects receiving periodic epithalamin courses with improved cardiovascular and immune parameters.
1992
Pineal Function Study
Elderly patients showed restoration of circadian melatonin rhythm and improved sleep/emotional stability using low-dose synthetic treatment.
2001
Retinal Degeneration Study
AMD patients achieved 90% positive response with only 5mcg per eye daily dosing.
2019
Lifespan Extension Study
Aging mice using 30-40mcg/kg showed 25% lifespan increase and reduced chromosomal aberrations.
2003
Neurogenesis Study
Human stem cells showed 1.6-1.8 fold upregulation of neurogenic markers at extremely low concentrations (0.01mcg/mL).
2020