Metabolic Peptide Cheat Sheet

Survodutide is an experimental weekly injection being studied for weight loss. It works by curbing appetite and boosting the number of calories your body burns, and early studies show it also helps with a liver condition called MASH.

L-Carnitine is a natural compound that helps your cells burn fat for energy and can support recovery after exercise. Injectable forms are popular because the body absorbs them better than carnitine taken by mouth.

BAM-15 is an experimental compound that helps the body burn fat without raising body temperature, which makes it safer than similar older compounds. Most of what we know comes from animal studies, not humans.

Mazdutide is an experimental injection being studied for weight loss and blood sugar control in type 2 diabetes. It works by curbing appetite and helping your body burn more energy.

Cagrilintide mimics a natural hormone called amylin to help curb your appetite.

MOTS-c is a mitochondrial peptide studied for metabolic health and exercise capacity. Weekly totals of 5–10 mg are typical, split into two or three injections.

SS-31 supports the mitochondria, the energy-producing parts of your cells.

This is Tirzepatide, a medication that activates two gut hormone pathways (GIP and GLP-1) to help with weight loss and blood sugar. Dosing starts at 2.5 mg once weekly for four weeks, then moves to 5 mg, and can rise in 2.5 mg steps every four weeks up to a maximum of 15 mg. Maintenance doses are 5, 10, or 15 mg weekly. Some people use very small 'microdoses' of 0.5 mg or less, or split the weekly dose into two injections, to reduce side effects. Splitting doses has shown to lower the peak blood level by roughly 28%, which is the usual explanation for less nausea.

NAD+ is a molecule your cells need to produce energy. Most protocols start around 20 mg and build up toward 100 mg over several injections, since injecting too much too fast commonly causes flushing, nausea, or a wave-like sensation. Starting lower and titrating up reduces this.

This is Semaglutide, a long-acting medication that helps control appetite and blood sugar. Dosing starts at 0.25 mg once weekly and steps up every four weeks: 0.25 → 0.5 → 1 → 1.7 → 2.4 mg, with most people settling at 1.7 or 2.4 mg. It's also available as a ready-to-use pen that doesn't require mixing with water, and as a once-daily pill.

This is Retatrutide, an experimental medication that activates three different gut hormone pathways at once. Doses are raised slowly over time, a process called titration, with each step held for four weeks. In the Phase 3 TRIUMPH trials, everyone starts at 2 mg per week and steps up from there: 2 → 4 → 6 → 9 → 12 mg. Earlier trials found that starting at 2 mg rather than 4 mg caused fewer stomach side effects while producing the same weight loss at 48 weeks. Some people take much smaller 'microdoses,' often around 0.5 mg per week, to reduce side effects further. Going up gradually matters because most side effects, especially nausea and other stomach issues, appear right after a dose increase rather than at a steady dose.

5-Amino-1MQ supports mitochondrial function and can help with fat loss.

AOD-9604 is a small fragment of growth hormone that helps promote fat burning. It's injected in the morning on an empty stomach. It won't dissolve properly in plain bacteriostatic water and will cloud, flake, or gel at the bottom of the vial instead. Add a small amount of 0.6% acetic acid first and swirl until the solution turns clear, then top it up with bacteriostatic water, around 2 mL. If it has already gelled, adding the acid a few drops at a time will usually bring it back.

SLU-PP-332 is a lab-made compound (not technically a peptide) that helps boost mitochondrial function and endurance, and is used for fat loss. All the dosing data we have comes from mouse studies — there's no human safety data yet.