Weight
Tesamorelin
Growth
36
Amino acids
Molecular weight
Peptide
Type
Tesamorelin is an FDA-approved synthetic GHRH analog designed for HIV-associated lipodystrophy treatment. It provides selective visceral fat targeting with 15-20% visceral fat reduction in clinical trials while preserving subcutaneous fat.
Top researched benefits
Overview of Tesamorelin
Subcutaneous injection provides optimal bioavailability for GHRH receptor binding and pulsatile GH release stimulation, selectively targeting visceral adipose tissue while sparing subcutaneous fat.
Weight Loss
- FDA-approved indication showing 15-20% visceral fat reduction in clinical trials.
- Unique mechanism that reduces dangerous visceral fat while sparing subcutaneous fat.
- Maintained weight loss with continuous treatment over 52+ weeks in clinical studies.
Metabolic
- 12.3% reduction in triglyceride levels.
- 7.2% improvement in cholesterol markers.
- 37% liver fat reduction over 12 months.
Body Composition
- Preserves lean muscle mass during fat loss.
- 26% increase in IGF-1 levels.
Storage
Powder: 20-25°C. Egrifta SV: use immediately. Egrifta WR: room temp up to 7 days
Frequency
Once daily (evening preferred for GH rhythm)
Typical Dose
1.4-2mg daily (FDA-approved: 2mg for HIV lipodystrophy)
Cycle Duration
Continuous therapy for maintained benefits
Chemical Makeup
Key benefits
FDA-approved formulation
Selective visceral fat targeting (15-20% reduction)
Proven clinical efficacy
Standardized dosing
37% liver fat reduction in NAFLD
Preserved subcutaneous fat
Community interest
This peptide is still gaining traction in the community.
GHRH Analog | Visceral Fat Reduction
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesTesamorelin Molecular Information
View the scientifc details of Tesamorelin.
36
Amino Acids
Tesamorelin
Tyr
Tyr
Position 1
Pro
Pro
Position 2
Ser
Ser
Position 3
Lys
Lys
Position 4
Pro
Pro
Position 5
Asp
Asp
Position 6
Asn
Asn
Position 7
Pro
Pro
Position 8
Gly
Gly
Position 9
Glu
Glu
Position 10
Asp
Asp
Position 11
Ala
Ala
Position 12
Pro
Pro
Position 13
Ala
Ala
Position 14
Glu
Glu
Position 15
Asp
Asp
Position 16
Leu
Leu
Position 17
Ala
Ala
Position 18
Arg
Arg
Position 19
Tyr
Tyr
Position 20
Tyr
Tyr
Position 21
Ser
Ser
Position 22
Ala
Ala
Position 23
Leu
Leu
Position 24
Arg
Arg
Position 25
His
His
Position 26
Tyr
Tyr
Position 27
Ile
Ile
Position 28
Asn
Asn
Position 29
Leu
Leu
Position 30
Ile
Ile
Position 31
Thr
Thr
Position 32
Arg
Arg
Position 33
Glu
Glu
Position 34
Arg
Arg
Position 35
Tyr
Tyr
Position 36
Molecular Weight
4255DaChain Length
36Amino AcidsType
PeptideTesamorelin Protocols
Subcutaneous injection to abdomen (avoid navel ±2 inches). Evening injection preferred for GH circadian rhythm alignment.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| HIV Lipodystrophy (FDA-approved) | 1.4 | 1 week range | SubQ |
| Visceral Fat Reduction | 2 | 1 week range | SubQ |
| Anti-aging/Body Composition | 1 | 5 week range | SubQ |
| NAFLD Treatment | 2 | 12 week range | SubQ |
| Cognitive Enhancement | 1 | 20 week range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Allow vial to reach room temperature
- Egrifta SV: Add 0.5mL sterile water to 2mg vial - use immediately
- Egrifta WR: Add 1.3mL bacteriostatic water to 11.6mg vial - stable 7 days
- Gently swirl (don't shake vigorously)
- Withdraw appropriate dose (~0.35mL for 1.4mg)
- Inject SubQ, rotating sites
- Store reconstituted WR at room temperature up to 7 days
Tesamorelin Cycle
The Tesamorelin Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 1-2
- IGF-1 levels begin to rise, possible mild water retention or joint discomfort
- Week 4-6
- Early metabolic changes; improved energy/sleep
- Week 8-12
- Visible visceral fat reduction begins, waist circumference may decrease
- Week 12-26
- Peak effects achieved with significant body composition improvements
Dosing tools
Tesamorelin Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
Tesamorelin
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Tesamorelin vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- Tesamorelin
- Dosing
- 1.4-2mg daily (FDA-approved: 2mg for HIV lipodystrophy)
- Dosing Frequency
- Once daily (evening preferred for GH rhythm)
- Cycle Duration
- Continuous therapy for maintained benefits
- Storage
- Powder: 20-25°C. Egrifta SV: use immediately. Egrifta WR: room temp up to 7 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Side effects
Monitor: Be careful when combining Tesamorelin with Ipamorelin, Sermorelin.
Contraindications
Active malignancy
Pituitary disorders
Pregnancy
Stop signs
Development of diabetes or severe glucose intolerance (HbA1c ≥6.5%)
Signs of malignancy
Severe hypersensitivity reactions
Excessive IGF-1 elevation (>2 SD above normal) with acromegaly symptoms
Bad signs
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Frequently asked questions
What benefits can peptides offer in research?
Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.
What are some exciting applications of peptides in modern science?
Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.
How do peptides influence health and wellness?
Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.
Where can I find the latest studies on peptide applications?
Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.
Are there any guidelines for using peptides in research?
Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.
What is the difference between peptides and proteins?
Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.
How should peptides be stored?
Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.
Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
TesamorelinResearch References
Tesamorelin is a fda approved compound
Tesamorelin
Tesamorelin is a fda approved compound
LIPO-010 FDA Pivotal Trial
Significant visceral adipose tissue reduction (-24 ± 41 cm² vs +2 ± 35 cm² placebo, p < 0.001) in HIV patients over 26 weeks.
2010
CTR-1011 Extended Safety Study
69% achieved ≥8% VAT reduction vs 33% placebo at 26-52 weeks.
2011
NAFLD Treatment Trial
37% liver fat reduction over 12 months with fibrosis progression prevention.
2019
Cognitive Enhancement Study
Improved executive function and verbal memory in healthy elderly and mild cognitive impairment cohorts at 1mg daily.
2012