Reviewed by the PeptideMind Team · Updated August 5, 2026
Tesamorelin (Egrifta) Dosage Calculator, Benefits & Side Effects
Use our free Tesamorelin (Egrifta) dosage calculator to get your dose, cycle length, and reconstitution amounts. Plus real trial data on visceral and liver fat reduction, and side effects.
As seen on
Tesamorelin Dosage Schedule
An evening injection taken on an empty stomach to stimulate natural growth hormone release, best known for helping reduce stubborn visceral belly fat.
Nightly Visceral Fat and Growth Hormone Protocol
10 weeks, focused on growth hormone support.
5 days per week
Taken Monday through Friday at night, on an empty stomach.
2 mg per injection
2 mg per injection, given just under the skin in the abdomen or thigh.
Tesamorelin stimulates natural growth hormone release and is best known for reducing visceral (belly) fat and can improve overall metabolism. Injected before bed, at least two hours after the last meal.
What is Tesamorelin?
Tesamorelin (Egrifta) is a lab-made version of a natural hormone (GHRH) that tells your pituitary gland to release growth hormone. It's FDA-approved specifically to reduce excess abdominal fat in people with HIV-related fat redistribution, and it's also widely used off-label for general belly fat reduction and body composition goals. It works by restoring more youthful, natural patterns of growth hormone release rather than overriding the body's own hormone system.
Weight
tesa
Growth
Where to buy Tesamorelin
Compare real-time Tesamorelin prices from vendors with third-party lab testing (COA), purity, and legitimacy, so you know exactly who's trustworthy before you buy.
Dose size
Chosen on COA purity, third-party testing, and service, no paid placements.
9 of 13 vendors third-party tested, COA purity 97.736–99.97% across published labs. Prices re-checked 16 days ago.
What Does Tesamorelin Do?
It attaches to the same pituitary receptor as the natural hormone GHRH, prompting the release of growth hormone in its normal pulsing pattern. The resulting rise in growth hormone and the related growth factor IGF-1 helps break down fat, particularly the deeper visceral fat around organs, while preserving muscle.
Binds the GHRH receptor
Attaches to the same pituitary receptor as the natural hormone GHRH.
Triggers GH & IGF-1
Prompts the release of growth hormone and the related growth factor IGF-1.
Targets visceral fat
Helps break down deep visceral fat around organs while preserving muscle.
Tesamorelin Targeted areas
Frequently Asked Questions About Tesamorelin
Straight answers on reconstitution, dosing, and safety, everything you need to research with confidence. For research reference only.
Tesamorelin Reconstitution Guide
Tesamorelin is supplied as a freeze-dried powder that must be mixed into a injectable solution before use. Available in 2mg, 5mg, 10mg sizes.
10 mg lyophilized vial
Tesamorelin is supplied as a freeze-dried powder that must be mixed into a injectable solution before use. Available in 2mg, 5mg, 10mg sizes.
3 mL bacteriostatic water
Adding 3 mL of bac water to a 10 mg vial gives a workable concentration for syringe dosing. More water makes microdosing easier; less concentrates each draw.
Storage after mixing
Keep the dry powder in the fridge, away from light. Once mixed with bacteriostatic water, refrigerate and use within about a month; the FDA-approved version (EGRIFTA WR) can be kept at room temperature and should be discarded after a week. After reconstitution, keep the vial refrigerated and use within 30 days.
Reconstitution steps
Remove caps & sanitize stoppers
Attach needle to syringe
Draw 3 mL bacteriostatic water
Insert needle into Tesamorelin vial
Release water gently down the side
Swirl to dissolve — don't shake
Check for full dissolution
Refrigerate Tesamorelin — good for 30 days
Chemical Makeup
36
Amino Acids
Tesamorelin
Tyr
YPosition 1
Pro
PPosition 2
Ser
SPosition 3
Lys
KPosition 4
Pro
PPosition 5
Asp
DPosition 6
Asn
NPosition 7
Pro
PPosition 8
Gly
GPosition 9
Glu
EPosition 10
Asp
DPosition 11
Ala
APosition 12
Pro
PPosition 13
Ala
APosition 14
Glu
EPosition 15
Asp
DPosition 16
Leu
LPosition 17
Ala
APosition 18
Arg
RPosition 19
Tyr
YPosition 20
Tyr
YPosition 21
Ser
SPosition 22
Ala
APosition 23
Leu
LPosition 24
Arg
RPosition 25
His
HPosition 26
Tyr
YPosition 27
Ile
IPosition 28
Asn
NPosition 29
Leu
LPosition 30
Ile
IPosition 31
Thr
TPosition 32
Arg
RPosition 33
Glu
EPosition 34
Arg
RPosition 35
Tyr
YPosition 36
What Are the Benefits of Tesamorelin?
What research says it may help with, and how it works in the body.
weight loss
This is an FDA-approved use, and clinical trials showed it reduced deep visceral fat by 15-20%.
In clinical studies, people kept the weight off as long as they stayed on treatment for over a year.
It works in a distinctive way, targeting the harmful deep belly fat around organs while leaving the fat just under the skin largely untouched.
metabolic
Triglycerides, a type of fat in the blood, dropped by 12.3%.
Cholesterol levels improved by 7.2%.
Fat stored in the liver dropped by 37% after a year of use.
body composition
It helps keep lean muscle intact even while the body is losing fat.
Levels of IGF-1, a hormone tied to growth and tissue repair, rose by 26%.
What Are the Side Effects of Tesamorelin?
Who should avoid it, warning signs to watch for, and what to know before combining it with other compounds.
Who Should Avoid It
Active malignancy
Pituitary disorders
Pregnancy
Stop Right Away If You Notice
Development of diabetes or severe glucose intolerance (HbA1c ≥6.5%)
Signs of malignancy
Severe hypersensitivity reactions
Excessive IGF-1 elevation (>2 SD above normal) with acromegaly symptoms
Milder Signs to Watch For
Is Tesamorelin FDA approved?
Tesamorelin is FDA approved.
FDA Approved
Tesamorelin has been reviewed and approved by the FDA for safety and efficacy in its approved indications.
Regulated Manufacturing
Manufactured under FDA-regulated quality standards, ensuring consistent purity and dosing.
Prescription Use
Legally available by prescription for its approved medical indications.
Tesamorelin Cycle Length: How Long Should It Last?
This breaks down how long a typical Tesamorelin cycle runs and what research suggests happens at each stage. Research shows that staying on a peptide continuously, without a break, may make it less effective over time.
That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again.
- Week 1-2
- IGF-1 levels begin to rise, possible mild water retention or joint discomfort
- Week 4-6
- Early metabolic changes; improved energy/sleep
- Week 8-12
- Visible visceral fat reduction begins, waist circumference may decrease
- Week 12-26
- Peak effects achieved with significant body composition improvements
Tesamorelin Research References
It is a fda approved compound
Tesamorelin
Tesamorelin is a fda approved compound
Significant visceral adipose tissue reduction (-24 ± 41 cm² vs +2 ± 35 cm² placebo, p < 0.001) in HIV patients over 26 weeks.
2010
69% achieved ≥8% VAT reduction vs 33% placebo at 26-52 weeks.
2011
37% liver fat reduction over 12 months with fibrosis progression prevention.
2019
Improved executive function and verbal memory in healthy elderly and mild cognitive impairment cohorts at 1mg daily.
2012
Browse user-created protocols
Real protocols from the community that include Tesamorelin
Weight
tesa
Weight
tesa
Healing
wol
Weight
tesa
Weight
GLP-3
Growth
ipa
Tesamorelin Comparisons
Weight
Tesa
Growth
Growth
Ser
Weight
Tesamorelin vs Sermorelin: Key differences comparison
Tesamorelin is FDA-approved for visceral fat reduction and is injected once daily. Sermorelin is no longer sold as an FDA-approved drug and is used off-label at bedtime for sleep, recovery, and anti-aging support. Here's how tesamorelin and sermorelin compare.
Weight
Tesa
Growth
Growth
CJC
Weight
Tesamorelin vs CJC-1295: Key differences comparison
Tesamorelin is FDA-approved for visceral fat reduction and is injected daily. CJC-1295 (with DAC) is an unapproved research peptide that binds a blood protein, allowing once- or twice-weekly dosing for sustained GH release. Here's how tesamorelin and CJC-1295 compare.