Skin
Melanotan II
Sexual
7
Amino acids
Molecular weight
Peptide
Type
Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that activates melanocortin receptors throughout the body. MC1R activation triggers melanin production for tanning, while MC4R affects sexual arousal and appetite control.
Top researched benefits
Overview of Melanotan II
Binds to melanocortin receptors (MC1R for tanning, MC4R for sexual function and appetite) to stimulate melanin production, enhance libido, and suppress appetite through hypothalamic pathways.
skin health
- Stimulates natural melanin production for tanning without requiring UV exposure.
- Increased melanin provides natural SPF protection against sun damage.
- May help address certain pigmentation disorders.
sexual health
- Improves sexual desire in both men and women through MC4R activation.
- 80% response rate in psychogenic erectile dysfunction studies.
- 73% of women reported arousal within 24 hours in clinical trials.
metabolic
- MC4R activation in hypothalamus reduces appetite (15% caloric intake reduction in studies).
- Enhanced fat oxidation through metabolic pathway activation.
Typical Dose
Loading: Start 0.25mg daily, increase to 0.5-1mg; Maintenance: 0.5-1mg 2-3x weekly
Frequency
Loading phase: Daily for first week, then tanning maintenance 2-3x weekly or as needed for sexual enhancement
Cycle Duration
4-8 weeks loading phase for tanning, then ongoing maintenance as needed
Storage
Refrigerate at 2-8°C wrapped in aluminum foil (light-sensitive); use reconstituted solution within 4 weeks
Chemical Makeup
Key benefits
Rapid tanning without UV exposure
Enhanced sexual function and libido
Appetite suppression
Improved mood via melanocortin activation
Photoprotection through increased melanin
Community interest
This peptide is still gaining traction in the community.
Synthetic Melanocortin Peptide | Tanning & Sexual Function
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoMelanotan II Molecular Information
View the scientifc details of Melanotan II.
7
Amino Acids
Melanotan II
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?
Position 1
Asp
Asp
Position 2
His
His
Position 3
Phe
Phe
Position 4
Arg
Arg
Position 5
Trp
Trp
Position 6
Lys
Lys
Position 7
Molecular Weight
1024.2DaChain Length
7Amino AcidsType
PeptideMelanotan II Protocols
Subcutaneous injection is the standard and most effective route. Start with low doses to assess tolerance due to nausea risk.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Initial loading phase | 0.25 | 1 week range | SubQ |
| Tanning maintenance | 0.5 | 2 week range | SubQ |
| Sexual enhancement | 0.5 | — | SubQ |
| Minimal side effects | 0.1 | — | SubQ |
| Photoprotection | 0.5 | 2 week range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clean vial tops with alcohol swab, let dry
- Draw 2mL bacteriostatic water for 10mg vial (creates 5mg/mL)
- Inject water slowly down vial side to avoid foaming
- Gently roll vial - do not shake vigorously
- Solution should be clear to slightly yellow
- Wrap vial in foil (MT-II is light sensitive)
- Store in refrigerator
- Draw dose with insulin syringe (typical: 0.05-0.2mL)
Melanotan II Cycle
The Melanotan II Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- Possible nausea, flushing, fatigue
- Day 3-7
- Increased spontaneous erections (men), enhanced arousal
- Week 1-2
- Noticeable skin darkening, reduced appetite
- Week 2-4
- Significant tanning, stabilized sexual effects
- Week 0-0
- Maintained tan with less frequent dosing
Dosing tools
Melanotan II Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Melanotan II
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Melanotan II vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Melanotan II
- Dosing
- Loading: Start 0.25mg daily, increase to 0.5-1mg; Maintenance: 0.5-1mg 2-3x weekly
- Dosing Frequency
- Loading phase: Daily for first week, then tanning maintenance 2-3x weekly or as needed for sexual enhancement
- Cycle Duration
- 4-8 weeks loading phase for tanning, then ongoing maintenance as needed
- Storage
- Refrigerate at 2-8°C wrapped in aluminum foil (light-sensitive); use reconstituted solution within 4 weeks
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Melanotan II interactions with other common peptides and substances.
Side effects
Contraindications
History of melanoma or dysplastic nevi
Pregnancy or breastfeeding
Cardiovascular conditions
Uncontrolled hypertension
Stop signs
Severe persistent nausea or vomiting
Chest pain or significant blood pressure elevation
Mole changes (size, shape, color) - monitor closely
Prolonged painful erections (priapism)
Severe headaches or vision changes
Allergic reactions (rash, swelling, breathing difficulty)
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
Melanotan IIResearch References
Melanotan II is a well studied compound
Melanotan II
Melanotan II is a well studied compound
Erectile Dysfunction Phase II Trial
0.025mg/kg dose achieved 80% response rate with significant improvement in psychogenic ED over 3 months.
2000
Melanogenesis & UV Protection Study
0.16mg/kg daily for 10 days increased eumelanin and achieved natural tan without UV exposure.
1999
Female Sexual Arousal Disorder Trial
Single dose of 0.025mg/kg resulted in 73% of premenopausal women reporting arousal within 24 hours.
2004
Appetite Reduction Study
15% reduction in caloric intake observed through MC4R activation.
2001