Sexual
HCG
Hormonal
0
Amino acids
Molecular weight
Peptide
Type
HCG is a glycoprotein hormone naturally produced by the placenta during pregnancy that binds LH receptors to stimulate testosterone and estrogen biosynthesis. FDA-approved for cryptorchidism, hypogonadotropic hypogonadism, and ovulation induction.
Top researched benefits
Overview of HCG
Binds to LH receptors on Leydig cells in testes, stimulating testosterone production with a half-life of 24-36 hours, peak levels 6-12 hours post-injection, and 40-50% bioavailability via SubQ or IM routes.
Male Fertility
- Maintains intratesticular testosterone at baseline during testosterone therapy, preventing atrophy and preserving fertility.
- FDA-approved for secondary hypogonadism; combined with FSH for spermatogenesis induction.
- Restores testicular function after anabolic steroid cycles.
Female Fertility
- FDA-approved trigger for follicular maturation; 15-25% pregnancy rate per cycle.
Pediatric
- FDA-approved for prepubertal undescended testes not due to anatomical obstruction; ~25% success rate.
Storage
Lyophilized: Room temperature. Reconstituted: 2-8°C, use within 30-60 days
Frequency
2-3 times weekly, or every other day for lower doses
Typical Dose
250-1500 IU (lower for TRT adjunct, higher for fertility)
Cycle Duration
Ongoing with TRT or 3-6 months for fertility protocols
No visual available
Due to this peptide having no amino acids, there is no molecular chain to display.
Chemical Makeup
Key benefits
Maintains testicular function during TRT
Preserves fertility and prevents testicular atrophy
Stimulates endogenous testosterone production
Induces ovulation in women
FDA-approved for multiple indications
Well-established safety profile
Community interest
This peptide is still gaining traction in the community.
Human Chorionic Gonadotropin | LH Receptor Agonist
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesHCG Molecular Information
View the scientifc details of HCG.
Molecular Weight
36DaChain Length
0Amino AcidsType
PeptideHCG Protocols
Subcutaneous or intramuscular injection. Administer 2-3 times weekly, evenly spaced. For TRT, many inject HCG on days between testosterone injections.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| TRT Adjunct (Low) | 250 | — | SubQ/IM |
| TRT Adjunct (Standard) | 500 | 2 week range | SubQ/IM |
| HCG Monotherapy | 1500 | 2 week range | IM |
| Fertility (with FSH) | 1500 | 2 week range | IM |
| Cryptorchidism (Pediatric) | 1000 | 2 week range | IM |
| Ovulation Trigger (Female) | 5000 | — | IM/SubQ |
| PCT Protocol | 1000 | 2 week range | SubQ/IM |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Remove vial and diluent from packaging
- Clean rubber stoppers with alcohol swabs
- Draw diluent into syringe (typically 1-2mL provided)
- Slowly inject diluent into HCG vial, aiming at vial wall
- Gently swirl to dissolve - do not shake vigorously
- Allow to sit until completely dissolved and clear
- Calculate concentration (e.g., 5000 IU in 2mL = 2500 IU/mL)
- Label with reconstitution date and concentration
- Store reconstituted HCG at 2-8°C
- Use within 30-60 days
HCG Cycle
The HCG Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Day 1-3
- Cellular-level action begins; no immediate noticeable effects
- Week 1-2
- Testosterone increase detectable on labs; possible mood/energy improvement
- Week 2-4
- Testicular fullness/size improvement noticeable; improved well-being
- Week 4-8
- Stable testosterone levels; fertility parameters beginning to improve
- Month 2-3
- Sperm count improvements if used for fertility; sustained testicular function
- Week 0-0
- Maintained testicular size and function with ongoing use
Dosing tools
HCG Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
HCG
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg HCG vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- HCG
- Dosing
- 250-1500 IU (lower for TRT adjunct, higher for fertility)
- Dosing Frequency
- 2-3 times weekly, or every other day for lower doses
- Cycle Duration
- Ongoing with TRT or 3-6 months for fertility protocols
- Storage
- Lyophilized: Room temperature. Reconstituted: 2-8°C, use within 30-60 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of HCG interactions with other common peptides and substances.
Side effects
Contraindications
Hormone-sensitive cancers (prostate, breast)
Pregnancy (except as prescribed)
Precocious puberty risk in children
Stop signs
Signs of gynecomastia (breast tenderness, swelling, nipple sensitivity)
Severe or persistent headaches
Signs of blood clots (leg swelling/pain, shortness of breath, chest pain)
Allergic reactions (rash, hives, difficulty breathing, facial swelling)
Severe abdominal pain or bloating in women (possible OHSS)
Testicular pain or swelling beyond normal
Significant mood changes (depression, aggression, severe irritability)
Vision changes
Bad signs
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Frequently asked questions
What benefits can peptides offer in research?
Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.
What are some exciting applications of peptides in modern science?
Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.
How do peptides influence health and wellness?
Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.
Where can I find the latest studies on peptide applications?
Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.
Are there any guidelines for using peptides in research?
Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.
What is the difference between peptides and proteins?
Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.
How should peptides be stored?
Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.
Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
HCGResearch References
HCG is a fda approved compound
HCG
HCG is a fda approved compound
HCG for Intratesticular Testosterone Maintenance
250 IU HCG every other day during TRT maintains intratesticular testosterone at baseline, preventing atrophy and preserving fertility.
2005
HCG Monotherapy for Hypogonadism
HCG monotherapy (1500-2000 IU twice weekly) effectively increased testosterone and improved symptoms while maintaining fertility.
2013
Spermatogenesis Induction with HCG/FSH
Combined HCG and FSH therapy induces spermatogenesis in 70-90% of men with hypogonadotropic hypogonadism.
2018
Cryptorchidism Treatment Meta-Analysis (Cochrane)
Meta-analysis of 1,231 boys showing ~25% success rate for hormonal treatment of cryptorchidism.
2014
Ovulation Induction Success Rates
HCG trigger achieves pregnancy rates of 15-25% per cycle in clomiphene/letrozole protocols.
2017