Sexual
Kisspeptin
Hormonal
9
Amino acids
Molecular weight
Peptide
Type
Kisspeptin acts as a master regulator of the reproductive system, stimulating GnRH neurons essential for puberty, fertility, and reproductive function.
Top researched benefits
Overview of Kisspeptin
Binds to GPR54/KISS1R receptors on hypothalamic GnRH neurons, triggering pulsatile GnRH release, which stimulates pituitary LH/FSH secretion and gonadal steroid production.
reproductive
- Restores reproductive hormone secretion in functional or congenital cases by stimulating dormant GnRH axis.
- Triggers oocyte maturation with 45% live birth rate and zero severe OHSS cases; safer than hCG.
- Restores reproductive hormone pulsatility in women with hypothalamic amenorrhea.
sexual function
- Modulates sexual brain processing; increases penile tumescence by 56% vs placebo.
- Modulates sexual and attraction brain processing; increases self-reported sexiness.
metabolic
- Preclinical evidence suggests influence on energy expenditure and activity levels.
Typical Dose
100-200 mcg per injection
Frequency
Single dose for testing, or 2-3 times weekly (NEVER daily - causes desensitization)
Cycle Duration
2-4 weeks
Storage
Lyophilized: Room temperature. Reconstituted: 2-8°C. KP-10: use within 7 days. KP-54: use within 14 days
Chemical Makeup
Key benefits
Potent reproductive hormone stimulation (LH/FSH)
Restoration of natural testosterone production
Fertility enhancement
Sexual function support
Hypogonadism treatment potential
Community interest
This peptide is still gaining traction in the community.
KISS1 Gene Product | Reproductive Neuropeptide
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoKisspeptin Molecular Information
View the scientifc details of Kisspeptin.
9
Amino Acids
Kisspeptin
Asn
Asn
Position 1
Trp
Trp
Position 2
Asn
Asn
Position 3
Ser
Ser
Position 4
Phe
Phe
Position 5
Gly
Gly
Position 6
Leu
Leu
Position 7
Arg
Arg
Position 8
Phe
Phe
Position 9
Molecular Weight
1DaChain Length
9Amino AcidsType
PeptideKisspeptin Protocols
Standard administration route; allows precise dosing and rapid hormone stimulation.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Gonadotropin stimulation | 100 | 2 week range | SubQ |
| Fertility support | 0.4 | — | SubQ (KP-54) |
| Sexual function (clinical) | 1 | 75 week range | IV infusion |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Clean work area and hands thoroughly with alcohol
- Calculate required BAC water volume
- Draw calculated water into syringe
- Inject slowly down vial side (not directly onto powder)
- Gently swirl until dissolved (never shake)
- Store in refrigerator at 2-8°C
- Use within 7 days for KP-10; 14 days for KP-54
Kisspeptin Cycle
The Kisspeptin Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- LH surge peaks at 3-5x baseline
- Week 0-0
- LH returns to baseline
- Day 1-2
- Testosterone/estradiol increase in response to LH
- Week 2-4
- Potential improvements in sexual function and libido
Dosing tools
Kisspeptin Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Kisspeptin
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Kisspeptin vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Kisspeptin
- Dosing
- 100-200 mcg per injection
- Dosing Frequency
- Single dose for testing, or 2-3 times weekly (NEVER daily - causes desensitization)
- Cycle Duration
- 2-4 weeks
- Storage
- Lyophilized: Room temperature. Reconstituted: 2-8°C. KP-10: use within 7 days. KP-54: use within 14 days
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Kisspeptin interactions with other common peptides and substances.
Sexual
hcg
Hormonal
HCG
COMPATIBLE
Serves as potentially safer alternative for IVF ovulation triggering.
Side effects
Contraindications
Not recommended during pregnancy or breastfeeding
Caution with cardiovascular disease history
Daily dosing causes receptor desensitization
Stop signs
Ovarian hyperstimulation signs: severe pelvic pain, bloating, nausea
Chest pain or cardiovascular symptoms
Severe headaches or visual disturbances
Persistent injection site reactions
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
KisspeptinResearch References
Kisspeptin is an emerging compound
Kisspeptin
Kisspeptin is an emerging compound
Kisspeptin for Hypoactive Sexual Desire Disorder in Men
Modulated sexual brain activity; increased penile tumescence by 56% vs placebo. JAMA Network Open.
2023
Kisspeptin for HSDD in Women
Modulated sexual and attraction processing; increased self-reported sexiness. JAMA Network Open.
2022
Kisspeptin as IVF Ovulation Trigger
45% live birth rate with zero severe OHSS; safer than hCG trigger. Journal of Clinical Investigation.
2017
Intranasal Kisspeptin Administration
Non-invasive delivery with rapid gonadotropin stimulation; stable 60-day formulation. eBioMedicine.
2025