Cognitive
Adamax
Longevity
7
Amino acids
Molecular weight
Peptide
Type
Adamax is a synthetic Semax analogue modified with an adamantane moiety, designed to enhance blood-brain barrier penetration and extend neurotrophin activity beyond that of parent Semax analogues. It upregulates brain-derived neurotrophic factor (BDNF) and sensitizes hippocampal TrkB receptors, promoting neurogenesis, synaptic plasticity, and neuroprotection. Used in preclinical research and among biohackers exploring cognitive enhancement, stroke recovery support, and anti-aging neurology.
Top researched benefits
Overview of Adamax
Adamax binds to and activates the TrkB receptor pathway by upregulating endogenous BDNF expression, enhancing hippocampal neurogenesis and synaptic remodeling. The adamantane group increases lipophilicity and metabolic stability, allowing sustained CNS activity and modulation of dopamine and serotonin signaling systems after crossing the blood-brain barrier.
cognitive
- Preliminary research suggests improvements in focus, mental clarity, memory consolidation, and complex task handling.
- BDNF upregulation and TrkB enhancement promote new neural connections and synaptic plasticity for long-term improvements.
- May enhance memory formation, information retention, and learning efficiency through hippocampal BDNF-TrkB pathway activation.
neuroprotective
- Preliminary observations indicate improved neurological outcomes through oxidative stress reduction and neuronal repair.
- Demonstrates antioxidant properties protecting against oxidative damage and inflammation-induced neuronal injury.
- Supports neuronal survival and growth through BDNF enhancement and microtubule stabilization.
mood
- Influences serotonin and dopamine to elevate mood and reduce depressive symptoms through neurotransmitter modulation.
- Anecdotal reports indicate reduced overwhelm and anxiety through balanced neurotransmitter activity.
- HPA axis modulation may improve stress response and emotional well-being.
Typical Dose
300–1000mcg per injection, titrated over cycle
Frequency
once daily
Cycle Duration
8–12 weeks on, equal duration off
Storage
Lyophilized: store at -20°C long-term or 2–8°C short-term. Reconstituted with bacteriostatic water: refrigerate at 2–8°C, use within 28 days.
Chemical Makeup
Key benefits
Upregulates BDNF in hippocampal tissue, directly supporting the growth and maintenance of neurons involved in learning and memory consolidation
Enhances TrkB receptor sensitivity, promoting synaptogenesis and dendritic arborization in preclinical neuronal models
Provides neuroprotection in stroke and ischemic injury models, with research showing improved neurological outcomes when administered post-event
Stimulates neurogenesis, enabling the brain to generate new neurons and potentially restore cognitive function that declines with age
Community interest
This peptide is still gaining traction in the community.
BDNF Upregulator | Cognitive Enhancement & Neuroprotection
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoAdamax Molecular Information
View the scientifc details of Adamax.
7
Amino Acids
Adamax
Met
Met
Position 1
Glu
Glu
Position 2
His
His
Position 3
Phe
Phe
Position 4
Pro
Pro
Position 5
Gly
Gly
Position 6
Pro
Pro
Position 7
Molecular Weight
984.1DaChain Length
7Amino AcidsType
PeptideAdamax Protocols
Subcutaneous injection is the primary delivery route for Adamax, yielding 85–92% bioavailability and producing stable plasma levels over 4–6 hours via steady absorption from abdominal adipose tissue. Morning administration within 60 minutes of waking is recommended to align with the natural cortisol rhythm and avoid insomnia from late-day dosing.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Improve working memory and sustained attention over a 2–3 week onset window | 250 | 1 day range | SubQ |
| Enhance focus and cognitive processing speed in experienced users who have titrated up from a lower starting dose | 500 | 1 day range | SubQ |
| Support BDNF upregulation and long-term neuroplasticity with daily once-daily maintenance dosing | 300 | 1 day range | SubQ |
| Modulate the HPA axis and reduce subjective anxiety scores through morning and afternoon dosing targeting stress-response pathways | 500 | 2 day range | SubQ |
| Support T-cell activity and cytokine signalling over a 21–28 day period using upper-range dosing | 1000 | 1 day range | SubQ |
| Maximize nootropic output during an 8–12 week structured cycle with full titration to peak dose | 1000 | 1 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Remove the lyophilized Adamax vial from -20°C storage and allow it to passively equilibrate to room temperature for 15–20 minutes — do not apply external heat
- Clean the rubber stopper of the Adamax vial and BAC water vial with an alcohol swab and allow to dry
- Draw 2 mL of bacteriostatic water into a reconstitution syringe — this yields a 1 mg/mL (1000 mcg/mL) concentration for a 10 mg vial
- Insert the needle into the Adamax vial at a 45-degree angle so the BAC water runs slowly down the inside wall of the glass — never inject directly onto the lyophilized powder
- Allow gravity to draw the solvent into contact with the powder, then gently swirl the vial in slow circular motions for 60–90 seconds until the solution becomes fully transparent
- Do not shake the vial — shaking introduces air bubbles and can degrade the peptide structure
- Label the vial with the reconstitution date and store at 2–8°C; use within 30 days
- For each dose, draw the calculated volume into a fresh insulin syringe (e.g., 0.05 mL = 50 mcg; 0.25 mL = 250 mcg at 1 mg/mL)
- Clean the injection site (abdomen, outer thigh) with an alcohol swab and allow to dry
- Pinch a fold of skin and inject subcutaneously at a 45–90 degree angle; inject slowly and withdraw without massaging the site
- Rotate injection sites across the abdomen or thigh to prevent localized tissue buildup
Adamax Cycle
The Adamax Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Potential acute cognitive enhancement and improved focus
- Week 1-2
- Enhanced mental clarity, reduced anxiety, improved mood
- Week 2-4
- Neuroplasticity benefits, sustained cognitive improvements
- Week 0-0
- Maximum neuroprotective and structural brain benefits
Dosing tools
Adamax Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Adamax
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Adamax vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Adamax
- Dosing
- 300–1000mcg per injection, titrated over cycle
- Dosing Frequency
- once daily
- Cycle Duration
- 8–12 weeks on, equal duration off
- Storage
- Lyophilized: store at -20°C long-term or 2–8°C short-term. Reconstituted with bacteriostatic water: refrigerate at 2–8°C, use within 28 days.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Adamax interactions with other common peptides and substances.
Healing
bpc
Longevity
BPC-157
COMPATIBLE
Different mechanisms—Adamax targets neurological function; BPC-157 focuses on tissue repair.
Cognitive
p21
Longevity
P21
SYNERGISTIC
Adamax incorporates adamantyl portion from P21; may complement cognitive benefits.
Cognitive
sema
Longevity
Semax
COMPATIBLE
Adamax is an enhanced derivative with improved stability and bioavailability.
Side effects
Contraindications
Pregnancy and breastfeeding
Cardiovascular conditions (without medical supervision)
Severe anxiety disorders
Uncontrolled hypertension
Stop signs
Persistent or severe headaches
Chest pain, heart palpitations, or significant blood pressure increases
Severe anxiety, insomnia, or mood disturbances
Unusual neurological symptoms or mental status changes
Persistent injection site reactions or infection signs
Gastrointestinal distress (nausea, vomiting, diarrhea)
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
AdamaxResearch References
Adamax is a preclinical compound
Adamax
Adamax is a preclinical compound
Semax Cognitive Enhancement in Fatigued Volunteers (Parent Compound)
Single intranasal administration (16 mcg/kg) resulted in 71% accuracy on memory tests versus 41% in controls, with effects lasting 24 hours.
n.d.
Semax in Stroke Recovery - BDNF Elevation (Parent Compound)
110 patients, 6000 mcg/day intranasal showed increased plasma BDNF levels, improved motor performance, enhanced functional independence.
n.d.
Adamax Stroke Recovery Preliminary Reports
Patients treated shortly after stroke showed better neurological outcomes through oxidative stress reduction.
n.d.
BDNF and TrkB Receptor Upregulation Studies
Adamax increases BDNF levels and enhances TrkB receptor sensitivity in hippocampus.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
