Weight
Hexarelin
Growth
6
Amino acids
Molecular weight
Peptide
Type
Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone secretagogue and one of the most potent GHRPs known, capable of stimulating significant pulsatile GH release from the pituitary. It acts as a ghrelin receptor agonist and additionally binds CD36 scavenger receptors in cardiac tissue, producing cardioprotective effects independent of GH release. It has been studied in clinical trials for growth disorders in children and is widely used in research exploring GH axis modulation, cardiovascular protection, and body composition.
Top researched benefits
Overview of Hexarelin
Hexarelin binds and activates the GHS-R1a (ghrelin receptor), a Gαq/11-coupled GPCR in pituitary somatotrophs, triggering phospholipase C activation, intracellular calcium release, and pulsatile GH secretion synergistic with endogenous GHRH. It also binds CD36 scavenger receptors in myocardial tissue, mediating cardioprotective signaling independently of the GH axis.
growth hormone enhancement
- Most potent GHRP for stimulating endogenous growth hormone release from the pituitary.
- Produces synergistic GH release when combined with GHRH, greater than sum of individual effects.
- Significant increases in IGF-1 levels through enhanced GH secretion.
cardiovascular
- Protective effects on cardiac tissue mediated through CD36 receptor activation.
- Reduces apoptosis of cardiomyocytes and controls cardiac action potential.
- Cardiotropic effects mediated by elevation of Ca2+ influx through voltage-gated calcium channels.
metabolic
- Beneficial effects on lipid metabolism via CD36 receptor in non-obese insulin-resistant models.
- Improved lean mass to fat ratio through GH and IGF-1 elevation.
Typical Dose
100mcg per injection
Frequency
2-3 times daily
Cycle Duration
12 weeks on, 4 weeks off
Storage
Lyophilized: store below -18°C, desiccated, away from light; stable at room temperature for 3-4 weeks. Reconstituted: refrigerate at 2-8°C, use within 10-14 days; avoid repeated freeze-thaw cycles.
Chemical Makeup
Key benefits
Stimulates robust pulsatile GH release from the pituitary, producing one of the highest GH pulses among synthetic GHRPs at equivalent doses
Supports lean muscle hypertrophy and strength gains through elevated GH and downstream IGF-1 production
Cardioprotective effects via CD36 receptor binding in myocardial tissue, independent of GH release — shown to improve cardiac function in preclinical models of heart failure
Accelerates recovery from soft-tissue injuries by increasing collagen synthesis and IGF-1-mediated tissue repair in tendons and ligaments
Community interest
This peptide is still gaining traction in the community.
GHS-R1a Agonist | GH Release & Cardioprotection
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoHexarelin Molecular Information
View the scientifc details of Hexarelin.
6
Amino Acids
Hexarelin
His
His
Position 1
?
?
Position 2
Ala
Ala
Position 3
Trp
Trp
Position 4
Phe
Phe
Position 5
Lys
Lys
Position 6
Molecular Weight
887.06DaChain Length
6Amino AcidsType
PeptideHexarelin Protocols
Subcutaneous injection is the primary delivery route for Hexarelin, offering the highest practical bioavailability (approximately 77%) and reliable GH pulse stimulation. Injections should be administered on an empty stomach — either fasted in the morning or 2–3 hours after the last meal before bed — to prevent food from blunting the GH response.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Anti-aging and GH optimization | 100 | 1 day range | SubQ |
| Body recomposition and fat loss | 200 | 1 day range | SubQ |
| Muscle growth and training recovery | 100 | 3 day range | SubQ |
| Cardiovascular and cardioprotection | 100 | 1 day range | SubQ |
| Maximum short-term GH pulse (blast phase) | 200 | 3 day range | SubQ |
| Conservative starter protocol | 100 | 1 day range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Allow the Hexarelin vial to reach room temperature before reconstitution
- Clean the rubber stopper of both the Hexarelin vial and the BAC water vial with an alcohol swab and allow to dry
- Draw 2 mL of bacteriostatic water into a syringe for a 2 mg vial, yielding 1000 mcg/mL, or 2.5 mL for a 5 mg vial to yield 2000 mcg/mL
- Insert the needle through the rubber stopper and slowly inject the BAC water down the inner wall of the vial — never directly onto the lyophilized powder
- Gently swirl the vial to dissolve the powder — do not shake, as shaking degrades the peptide
- Store reconstituted Hexarelin in the refrigerator at 2–8°C and use within 28 days
- Before injection, clean the chosen injection site (abdomen 2 inches from the navel, or the outer thigh) with an alcohol swab and allow to dry
- Pinch the skin, insert the insulin syringe at a 45–90 degree angle, inject slowly, then withdraw and apply gentle pressure
- Rotate injection sites between the left and right sides of the abdomen or alternate thighs to prevent lipodystrophy
Hexarelin Cycle
The Hexarelin Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- GH spike within 15-30 minutes of injection
- Week 1-2
- Improved sleep quality and recovery
- Week 2-4
- Enhanced energy and well-being
- Week 4-8
- Noticeable improvements in body composition
- Week 8-12
- Maximum benefits; consider cycling to prevent desensitization
Dosing tools
Hexarelin Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Hexarelin
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Hexarelin vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Hexarelin
- Dosing
- 100mcg per injection
- Dosing Frequency
- 2-3 times daily
- Cycle Duration
- 12 weeks on, 4 weeks off
- Storage
- Lyophilized: store below -18°C, desiccated, away from light; stable at room temperature for 3-4 weeks. Reconstituted: refrigerate at 2-8°C, use within 10-14 days; avoid repeated freeze-thaw cycles.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Hexarelin interactions with other common peptides and substances.
Weight
ghr
Growth
GHRP-2
COMPATIBLE
Similar mechanism; typically not stacked together but can be alternated.
Weight
ghrp
Growth
GHRP-6
COMPATIBLE
Same receptor target; Hexarelin is more potent with less appetite stimulation.
Weight
ipa
Growth
Ipamorelin
COMPATIBLE
Both are GHRPs; Hexarelin is more potent but may have more side effects.
Side effects
Contraindications
Active cancer or history of cancer
Pregnancy or breastfeeding
Pituitary disorders
WADA prohibited for competitive athletes
Stop signs
Severe or persistent headaches
Unusual swelling
Signs of carpal tunnel syndrome
Allergic reactions
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
HexarelinResearch References
Hexarelin is a phase 2 compound
Hexarelin
Hexarelin is a phase 2 compound
Hexarelin Improves Lipid Metabolic Aberrations in Insulin-Resistant Mice
Hexarelin treatment improved lipid metabolism via CD36 receptor in non-obese insulin-resistant MKR mice.
n.d.
Effect of Repeated Hexarelin Administration on GH Responsivity
Demonstrated synergistic GH response when hexarelin co-administered with GHRH, greater than arithmetic sum.
n.d.
Hexarelin Modulates GHS-R1a Expression
Hexarelin significantly increased pituitary and hypothalamic GHS-R1a mRNA levels.
n.d.
Kinetics and Disposition of Hexarelin in Rats
Half-life of 75.9 min; rapidly absorbed subcutaneously; stable against proteolytic enzymes.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
