Bronchogen
FDA APPROVAL PENDING
Preclinical
Immunity
Bronchogen
4
Amino acids
Molecular weight
Peptide
Type
Bronchogen (Ala-Glu-Asp-Leu, AEDL) is a synthetic tetrapeptide bioregulator developed by Vladimir Khavinson targeting bronchial epithelial tissue. It modulates gene expression in lung cells through epigenetic mechanisms, reducing inflammation and promoting structural repair of airway tissue. It is used in research for chronic obstructive pulmonary disease, chronic bronchitis, and respiratory recovery.
Top researched benefits
Overview of Bronchogen
Bronchogen interacts with core histones (H1, H2B, H3, H4) to modulate endonuclease activity and restore transcriptional activity in hypermethylated bronchial cell gene promoters. It reduces pro-inflammatory cytokines (TNF-α, IL-6) and neutrophilic inflammation while upregulating surfactant protein B and secretory IgA in bronchial epithelium.
respiratory support
- Supports bronchial tissue through gene expression regulation.
- Helps maintain respiratory epithelium health.
- Regulates protein synthesis in lung tissue.
antiaging
- Addresses age-related changes in bronchial tissue.
- Modulates gene expression in respiratory cells.
Typical Dose
500mcg per injection
Frequency
once daily
Cycle Duration
4-6 week cycle with 4-6 month break between cycles
Storage
Lyophilized: store at 2–8°C or -20°C for long-term preservation. Reconstituted with bacteriostatic water: refrigerate at 2–8°C and use within 28 days.
Chemical Makeup
Key benefits
Reduces goblet cell hyperplasia and squamous metaplasia in bronchial epithelium, restoring normal ciliated cell architecture in COPD models
Decreases neutrophilic airway inflammation by suppressing TNF-α and IL-6, reducing exacerbation frequency in chronic bronchitis
Improves spirometric measures including FEV1 and FVC in clinical observations of COPD and chronic bronchitis patients
Upregulates surfactant protein B and secretory IgA, enhancing mucosal immune defense and mucociliary clearance
Community interest
This peptide is still gaining traction in the community.
Bronchial Bioregulator | Respiratory Health & COPD
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoBronchogen Molecular Information
View the scientifc details of Bronchogen.
4
Amino Acids
Bronchogen
Ala
Ala
Position 1
Glu
Glu
Position 2
Asp
Asp
Position 3
Leu
Leu
Position 4
Molecular Weight
446.45DaChain Length
4Amino AcidsType
PeptideBronchogen Protocols
Subcutaneous injection is the primary route for Bronchogen, offering higher and more consistent bioavailability than oral administration for bronchial tissue repair. Injections are administered in the evening, several hours after eating, rotating between abdomen, thigh, and upper arm.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Initiate bronchial tissue repair and establish tolerance in new users | 0.5 | 1 day range | SubQ |
| Support lung health and accelerate bronchial tissue repair | 1 | 1 day range | SubQ |
| Maximize respiratory support and accelerate recovery of damaged bronchial epithelium | 1 | 1 day range | SubQ |
| Support gene regulation and DNA stability in bronchial tissue | 1 | 1 day range | SubQ |
| Address persistent or chronic respiratory conditions with intensive bronchial regeneration | 2 | 1 day range | SubQ |
| Sustain long-term bronchial health with periodic cycling to prevent tolerance | 1 | 3 month range | SubQ |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Draw 2 mL of bacteriostatic water (BAC water) into an insulin syringe
- Insert the needle through the rubber stopper of the Bronchogen vial at an angle
- Inject the BAC water slowly down the inner wall of the vial — do not aim the stream directly at the powder
- Remove the syringe and gently swirl the vial until the powder is fully dissolved — do not shake
- Allow the solution to sit for 1–2 minutes if any cloudiness remains before drawing a dose
- Store the reconstituted vial in the refrigerator at 2–8°C, protected from light, and use within 30 days
- For each dose, draw the calculated volume into a fresh insulin syringe and inject subcutaneously at a 45-degree angle, rotating injection sites daily
Bronchogen Cycle
The Bronchogen Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Gene expression modulation begins
- Week 0-0
- Effects persist due to epigenetic changes
- Week 0-0
- Respiratory function improvements
- Week 0-0
- Cumulative benefits with periodic cycles
Dosing tools
Bronchogen Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Bronchogen
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Bronchogen vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Bronchogen
- Dosing
- 500mcg per injection
- Dosing Frequency
- once daily
- Cycle Duration
- 4-6 week cycle with 4-6 month break between cycles
- Storage
- Lyophilized: store at 2–8°C or -20°C for long-term preservation. Reconstituted with bacteriostatic water: refrigerate at 2–8°C and use within 28 days.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Bronchogen interactions with other common peptides and substances.
Longevity
cho
Immunity
Chonluten
SYNERGISTIC
Related respiratory bioregulators; complementary mechanisms.
Longevity
cry
Immunity
Crystagen
COMPATIBLE
Both have immune-modulating properties; different tissue targets.
Longevity
epi
Immunity
Epitalon
SYNERGISTIC
Often combined in comprehensive anti-aging Khavinson protocols.
Longevity
vil
Immunity
Vilon
COMPATIBLE
Part of Khavinson bioregulator family; targets different tissue.
Side effects
Contraindications
Active respiratory emergencies (seek medical care)
Known hypersensitivity
Pregnancy or breastfeeding
Stop signs
Allergic reactions
Unusual respiratory symptoms
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
BronchogenResearch References
Bronchogen is a preclinical compound
Bronchogen
Bronchogen is a preclinical compound
Khavinson Peptide Bioregulators
Comprehensive review of bioregulator peptides including respiratory bioregulators.
n.d.
Short Peptides and Bronchial Function
Tetrapeptides derived from bronchial tissue regulate protein synthesis in respiratory cells.
n.d.
Bioregulator Peptides and Respiratory Health
Short peptides support bronchopulmonary system through epigenetic mechanisms.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
