Longevity
Pancragen
Metabolic
4
Amino acids
Molecular weight
Peptide
Type
Pancragen is a Khavinson bioregulator tetrapeptide (KEDW) originally isolated from bovine pancreatic cells. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it directly interacts with DNA to regulate pancreatic gene expression. Research in old rhesus monkeys demonstrated that Pancragen corrected impaired glucose tolerance, normalized insulin and C-peptide levels, and improved endocrine pancreatic function. It is considered safe and effective for age-related metabolic disturbances.
Top researched benefits
Overview of Pancragen
Pancragen works through epigenetic regulation by interacting with chromatin complexes and DNA structures to modulate pancreatic gene expression. Research shows it upregulates critical transcription factors for pancreatic cell maturation including Pdx1, Pax6, Ptf1a, Foxa2, Nkx2.2, and Pax4. Its small size (4 amino acids, ~576 Da) allows it to traverse cellular membranes and interact with nuclear components including histones and DNA.
Metabolic Support
- Corrects age-related glucose tolerance disturbances in primate studies.
- Reduces incidence and magnitude of metabolic syndrome.
- Helps control blood sugar through pancreatic function support.
Pancreatic Health
- Impacts differentiation of pancreatic cells during aging.
- Improves endocrine function of the pancreas.
- Addresses age-related imbalance of pancreatic function.
Antiaging
- Directly interacts with DNA to regulate pancreatic gene expression.
Storage
Capsules at room temperature; reconstituted injectable at 2-8°C refrigerated
Frequency
Daily for 10-20 days per cycle
Typical Dose
10-20mg daily
Cycle Duration
10-20 days
Chemical Makeup
Key benefits
Corrects impaired glucose tolerance
Normalizes insulin levels
Normalizes C-peptide levels
Improves endocrine pancreatic function
Supports pancreatic cell differentiation
Regulates melatonin expression
Reduces metabolic syndrome incidence
Upregulates key pancreatic transcription factors
Community interest
This peptide is still gaining traction in the community.
KEDW Tetrapeptide | Pancreas Bioregulator
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesPancragen Molecular Information
View the scientifc details of Pancragen.
4
Amino Acids
Pancragen
Lys
Lys
Position 1
Glu
Glu
Position 2
Asp
Asp
Position 3
Trp
Trp
Position 4
Molecular Weight
575.6DaChain Length
4Amino AcidsType
PeptidePancragen Protocols
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard protocol | 10 | 10 week range | Oral capsules |
| Maintenance | 10 | 2 week range | Oral capsules |
Pancragen Cycle
The Pancragen Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Gene expression modulation begins
- Week 0-0
- Effects persist due to epigenetic changes
- Week 0-0
- Glucose tolerance and pancreatic function improvements
- Week 0-0
- Cumulative benefits with periodic cycles
Dosing tools
Pancragen Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
0.3mL / 30 units
5 units
0.050 mL
1 mL
2 mL
3 mL
5 mL
Custom
Conversion: 1,000 mcg = 1 mg
Injection Results
Based on your vial and dilution inputs.
Safe concentration range
Pancragen
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Pancragen vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
Research Purposes Only
These calculators are provided for educational and research purposes only. Always verify calculations and consult with qualified professionals. The information provided is not medical advice. Peptides should only be used in accordance with applicable laws and regulations.
Reference Guide
Dosing Cycle
- Peptide
- Pancragen
- Dosing
- 10-20mg daily
- Dosing Frequency
- Daily for 10-20 days per cycle
- Cycle Duration
- 10-20 days
- Storage
- Capsules at room temperature; reconstituted injectable at 2-8°C refrigerated
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Pancragen interactions with other common peptides and substances.
Longevity
epi
Immunity
Epitalon
SYNERGISTIC
Often combined in comprehensive anti-aging Khavinson protocols.
Longevity
liv
Immunity
Livagen
COMPATIBLE
Different organ targets; can be used in comprehensive bioregulator protocols.
Longevity
vil
Immunity
Vilon
COMPATIBLE
Part of Khavinson bioregulator family; targets different tissue.
Side effects
Contraindications
Active pancreatic emergencies (seek medical care)
Known hypersensitivity
Pregnancy or breastfeeding
Type 1 diabetes (consult physician)
Stop signs
Allergic reactions
Unusual blood sugar changes
Signs of hypoglycemia
Bad signs
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Frequently asked questions
What benefits can peptides offer in research?
Peptides can support cellular repair, immune function, metabolic health, and tissue regeneration. Research suggests they may help with recovery, sleep quality, skin health, and cognitive function, depending on the specific peptide and its mechanism of action.
What are some exciting applications of peptides in modern science?
Current research explores peptides for longevity, muscle recovery, wound healing, metabolic disorders, and neuroprotection. Scientists are also investigating peptide-based drug delivery and targeted therapies that could offer more precise treatment options.
How do peptides influence health and wellness?
Peptides work by binding to receptors on cells and triggering specific biological responses. Depending on the peptide, they may promote growth hormone release, support collagen production, modulate inflammation, or influence neurotransmitter activity—each with different implications for health and wellness.
Where can I find the latest studies on peptide applications?
Peer-reviewed journals such as Nature, Science, and specialized publications like Peptides and the Journal of Peptide Science publish ongoing research. PubMed and Google Scholar are useful for searching studies by peptide name or condition.
Are there any guidelines for using peptides in research?
Research use of peptides typically follows institutional review board (IRB) protocols and regulatory guidelines. Dosage, administration route, and safety monitoring should align with published literature and applicable regulations in your jurisdiction.
What is the difference between peptides and proteins?
Peptides are short chains of amino acids (typically under 50), while proteins are longer chains that fold into complex structures. Peptides are often more stable, easier to synthesize, and can cross cell membranes more readily, making them attractive for therapeutic applications.
How should peptides be stored?
Most peptides require refrigeration (2–8°C) and protection from light. Reconstituted peptides often have shorter stability and may need to be used within days or weeks. Always follow the manufacturer's or research protocol's storage instructions.
Can peptides be taken orally?
Some peptides are bioavailable orally, but many are broken down by digestive enzymes before reaching the bloodstream. Subcutaneous injection, nasal administration, or other routes are often used in research to improve bioavailability. The optimal route depends on the specific peptide.
PancragenResearch References
Pancragen is a moderate research compound
Pancragen
Pancragen is a moderate research compound
Correction of Impaired Glucose Tolerance Using Tetrapeptide (Pancragen) in Old Female Rhesus Monkeys
Pancragen normalized insulin and C-peptide levels, suggesting recovery of disturbed glucose tolerance in old animals.
n.d.
Tetrapeptide KEDW Interacts with DNA and Regulates Gene Expression
KEDW directly interacts with DNA and regulates pancreatic gene expression.
n.d.
Impacts of Pancragen on Differentiation of Pancreatic Cells During Aging
Pancragen affects pancreatic cell differentiation during aging process.
n.d.
Prospects of Using Pancragen for Metabolic Disorders in Elderly
Pancragen shows promise for correction of metabolic disorders in elderly people.
n.d.