Longevity
Pancragen
Metabolic
4
Amino acids
Molecular weight
Peptide
Type
Pancragen is a Khavinson bioregulator tetrapeptide (KEDW) originally isolated from bovine pancreatic cells. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it directly interacts with DNA to regulate pancreatic gene expression. Research in old rhesus monkeys demonstrated that Pancragen corrected impaired glucose tolerance, normalized insulin and C-peptide levels, and improved endocrine pancreatic function. It is considered safe and effective for age-related metabolic disturbances.
Top researched benefits
Overview of Pancragen
Pancragen works through epigenetic regulation by interacting with chromatin complexes and DNA structures to modulate pancreatic gene expression. Research shows it upregulates critical transcription factors for pancreatic cell maturation including Pdx1, Pax6, Ptf1a, Foxa2, Nkx2.2, and Pax4. Its small size (4 amino acids, ~576 Da) allows it to traverse cellular membranes and interact with nuclear components including histones and DNA.
metabolic support
- Corrects age-related glucose tolerance disturbances in primate studies.
- Reduces incidence and magnitude of metabolic syndrome.
- Helps control blood sugar through pancreatic function support.
pancreatic health
- Impacts differentiation of pancreatic cells during aging.
- Improves endocrine function of the pancreas.
- Addresses age-related imbalance of pancreatic function.
antiaging
- Directly interacts with DNA to regulate pancreatic gene expression.
Typical Dose
10-20mg daily
Frequency
Daily for 10-20 days per cycle
Cycle Duration
10-20 days
Storage
Capsules at room temperature; reconstituted injectable at 2-8°C refrigerated
Chemical Makeup
Key benefits
Corrects impaired glucose tolerance
Normalizes insulin levels
Normalizes C-peptide levels
Improves endocrine pancreatic function
Supports pancreatic cell differentiation
Regulates melatonin expression
Reduces metabolic syndrome incidence
Upregulates key pancreatic transcription factors
Community interest
This peptide is still gaining traction in the community.
KEDW Tetrapeptide | Pancreas Bioregulator
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoPancragen Molecular Information
View the scientifc details of Pancragen.
4
Amino Acids
Pancragen
Lys
Lys
Position 1
Glu
Glu
Position 2
Asp
Asp
Position 3
Trp
Trp
Position 4
Molecular Weight
575.6DaChain Length
4Amino AcidsType
PeptidePancragen Protocols
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Standard protocol | 10 | 10 week range | Oral capsules |
| Maintenance | 10 | 2 week range | Oral capsules |
Pancragen Cycle
The Pancragen Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Week 0-0
- Gene expression modulation begins
- Week 0-0
- Effects persist due to epigenetic changes
- Week 0-0
- Glucose tolerance and pancreatic function improvements
- Week 0-0
- Cumulative benefits with periodic cycles
Dosing tools
Pancragen Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Pancragen
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Pancragen vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Pancragen
- Dosing
- 10-20mg daily
- Dosing Frequency
- Daily for 10-20 days per cycle
- Cycle Duration
- 10-20 days
- Storage
- Capsules at room temperature; reconstituted injectable at 2-8°C refrigerated
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Pancragen interactions with other common peptides and substances.
Longevity
epi
Immunity
Epitalon
SYNERGISTIC
Often combined in comprehensive anti-aging Khavinson protocols.
Longevity
liv
Immunity
Livagen
COMPATIBLE
Different organ targets; can be used in comprehensive bioregulator protocols.
Longevity
vil
Immunity
Vilon
COMPATIBLE
Part of Khavinson bioregulator family; targets different tissue.
Side effects
Contraindications
Active pancreatic emergencies (seek medical care)
Known hypersensitivity
Pregnancy or breastfeeding
Type 1 diabetes (consult physician)
Stop signs
Allergic reactions
Unusual blood sugar changes
Signs of hypoglycemia
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
PancragenResearch References
Pancragen is a moderate research compound
Pancragen
Pancragen is a moderate research compound
Correction of Impaired Glucose Tolerance Using Tetrapeptide (Pancragen) in Old Female Rhesus Monkeys
Pancragen normalized insulin and C-peptide levels, suggesting recovery of disturbed glucose tolerance in old animals.
n.d.
Tetrapeptide KEDW Interacts with DNA and Regulates Gene Expression
KEDW directly interacts with DNA and regulates pancreatic gene expression.
n.d.
Impacts of Pancragen on Differentiation of Pancreatic Cells During Aging
Pancragen affects pancreatic cell differentiation during aging process.
n.d.
Prospects of Using Pancragen for Metabolic Disorders in Elderly
Pancragen shows promise for correction of metabolic disorders in elderly people.
n.d.