Teriparatide
FDA APPROVED
Fda Approved
Healing
Teriparatide
29
Amino acids
Molecular weight
Peptide
Type
Teriparatide is a recombinant fragment of human parathyroid hormone comprising its first 34 N-terminal amino acids, marketed as Forteo and Bonsity. It acts as an anabolic agent that stimulates new bone formation through intermittent PTH receptor activation, increasing bone mineral density and reducing fracture risk. It is FDA-approved for postmenopausal women, men with primary or hypogonadal osteoporosis, and patients with glucocorticoid-induced osteoporosis at high fracture risk.
Top researched benefits
Overview of Teriparatide
Teriparatide binds to PTH type 1 receptors (PTH1R), G-protein coupled receptors expressed on osteoblasts and osteocytes, triggering downstream upregulation of IGF-1 and FGF-2 and activation of the Wnt/β-catenin signaling pathway. Intermittent daily dosing favors bone formation over resorption by suppressing sclerostin and DKK1, net anabolic inhibitors of the Wnt pathway, unlike continuous PTH exposure which drives resorption.
osteoporosis fdaapproved
- FDA-approved for women with osteoporosis at high risk of fracture.
- FDA-approved for men with primary or hypogonadal osteoporosis at high risk.
- FDA-approved for men and women with osteoporosis from sustained corticosteroid use.
bone health research
- Research interest in accelerating fracture healing and bone repair.
- Investigated for jawbone regeneration in dental applications.
Typical Dose
20mcg per injection
Frequency
once daily subcutaneous injection
Cycle Duration
up to 24 months total lifetime use
Storage
Pre-filled pen: refrigerate at 2–8°C; do not freeze. Discard 28 days after first use. May be kept at room temperature (up to 25°C) for up to 36 hours during travel.
Chemical Makeup
Key benefits
Increases lumbar spine bone mineral density by approximately 9–13% over 18–24 months of treatment
Reduces the risk of new vertebral fractures by 65% compared to placebo in postmenopausal women
Reduces nonvertebral fragility fractures by 53%, including hip and wrist fractures
Stimulates de novo bone formation by activating PTH1R on osteoblasts, producing net anabolic rather than solely antiresorptive effects
Community interest
This peptide is still gaining traction in the community.
PTH(1-34) Analog | Anabolic Bone-Building Agent
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoTeriparatide Molecular Information
View the scientifc details of Teriparatide.
29
Amino Acids
Teriparatide
Asn
Asn
Position 1
Thr
Thr
Position 2
Glu
Glu
Position 3
Arg
Arg
Position 4
Met
Met
Position 5
Ile
Ile
Position 6
Asn
Asn
Position 7
Ala
Ala
Position 8
Leu
Leu
Position 9
Pyl
Pyl
Position 10
Phe
Phe
Position 11
Pro
Pro
Position 12
Ala
Ala
Position 13
Arg
Arg
Position 14
Ala
Ala
Position 15
Thr
Thr
Position 16
His
His
Position 17
Tyr
Tyr
Position 18
Arg
Arg
Position 19
Pyl
Pyl
Position 20
Ile
Ile
Position 21
Asp
Asp
Position 22
His
His
Position 23
Pyl
Pyl
Position 24
Arg
Arg
Position 25
Met
Met
Position 26
Pyl
Pyl
Position 27
Asn
Asn
Position 28
Glu
Glu
Position 29
Molecular Weight
4117.72DaChain Length
29Amino AcidsType
PeptideTeriparatide Protocols
Subcutaneous injection into the thigh or abdominal wall is the only FDA-approved delivery route for teriparatide and the standard of care for osteoporosis management. Teriparatide comes pre-filled in a pen device requiring no reconstitution; inject once daily at the same time each day, preferably with the patient seated in case of orthostatic hypotension.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Postmenopausal Osteoporosis — Standard Daily Dosing | 20 | 1 day range | SubQ (thigh or abdomen) |
| Male Osteoporosis (Primary or Hypogonadal) | 20 | 1 day range | SubQ (thigh or abdomen) |
| Glucocorticoid-Induced Osteoporosis | 20 | 1 day range | SubQ (thigh or abdomen) |
| Stress Fracture Healing | 20 | 1 day range | SubQ (thigh or abdomen) |
| Once-Weekly Low-Dose Protocol (Japan/Korea approval) | 56.5 | 1 week range | SubQ (thigh or abdomen) |
| Twice-Weekly Dosing Protocol | 28.2 | 2 week range | SubQ (thigh or abdomen) |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Remove the teriparatide pen from the refrigerator and allow it to come to room temperature for approximately 30 minutes before injecting
- Wash hands thoroughly with soap and water before handling the pen or needle
- Attach a new, sterile needle to the pen for each injection — never reuse needles
- Prime the pen according to the manufacturer instructions to remove air and ensure accurate dosing
- Clean the injection site (thigh or lower abdomen) with an alcohol swab and allow to dry
- Pinch the skin lightly and insert the needle at a 45–90 degree angle; inject the dose by pressing the pen button
- Withdraw the needle, apply gentle pressure to the site without rubbing
- Remove and safely dispose of the needle in a puncture-resistant sharps container immediately after use
- Replace the pen cap and return the pen (without needle attached) to the refrigerator; store at 2–8°C and discard after 28 days regardless of remaining content
- Sit or lie down for several minutes after injection to guard against dizziness from orthostatic hypotension
Teriparatide Cycle
The Teriparatide Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Month 1-3
- Bone formation begins; spine BMD increases
- Month 3-6
- Continued bone density improvements
- Month 6-12
- 5-9% spine BMD increase; fracture risk reduction
- Week 0-0
- Maximum benefits achieved; transition to maintenance
Dosing tools
Teriparatide Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Teriparatide
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Teriparatide vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Teriparatide
- Dosing
- 20mcg per injection
- Dosing Frequency
- once daily subcutaneous injection
- Cycle Duration
- up to 24 months total lifetime use
- Storage
- Pre-filled pen: refrigerate at 2–8°C; do not freeze. Discard 28 days after first use. May be kept at room temperature (up to 25°C) for up to 36 hours during travel.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Teriparatide interactions with other common peptides and substances.
Side effects
Contraindications
Paget's disease of bone
Prior skeletal radiation therapy
History of skeletal malignancies
Metabolic bone diseases other than osteoporosis
Pre-existing hypercalcemia
Pregnancy
Stop signs
Signs of hypercalcemia (confusion, fatigue, nausea)
Persistent bone pain
Allergic reactions
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
TeriparatideResearch References
Teriparatide is a fda approved compound
Teriparatide
Teriparatide is a fda approved compound
Teriparatide
Intermittent PTH exposure induces bone formation more than resorption; FDA-approved for osteoporosis.
n.d.
The effect of teriparatide therapy on bone density in men with osteoporosis
Spine BMD increased 5.9% (20mcg) and 9.0% (40mcg); femoral neck increased 1.5-2.9%.
n.d.
Teriparatide: 2.5 Years of Experience
Reduced vertebral fractures by 65% and nonvertebral fractures by 35% after 20 months.
n.d.
Parathyroid Hormone (1-84) and Teriparatide in Postmenopausal Osteoporosis
Initial formation without resorption creates 'anabolic window' for rapid bone volume increase.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
