Abaloparatide
FDA APPROVED
Fda Approved
Healing
Abaloparatide
34
Amino acids
Molecular weight
Peptide
Type
Abaloparatide (Tymlos) is an FDA-approved synthetic 34-amino acid analog of parathyroid hormone-related protein (PTHrP) used to treat osteoporosis in postmenopausal women and men at high risk for fracture. It selectively activates the PTH1 receptor to stimulate anabolic bone formation, increasing bone mineral density and reducing fracture incidence. It is administered as a daily subcutaneous injection and is limited to a maximum cumulative lifetime use of 2 years.
Top researched benefits
Overview of Abaloparatide
Abaloparatide selectively binds the RG conformation of the PTH1 receptor (PTH1R), a G-protein-coupled receptor, producing rapid but transient cAMP signaling via the Gs-protein pathway. This transient activation preferentially drives osteoblast-mediated bone formation over osteoclast resorption, resulting in a net anabolic effect on bone.
osteoporosis fdaapproved
- FDA-approved for postmenopausal women with osteoporosis at high risk for fracture or who have failed other therapies.
- FDA-approved for men with osteoporosis at high risk for fracture or intolerant to other treatments.
bone health research
- Phase III trials demonstrated substantial reduction in vertebral and nonvertebral fractures.
- ACTIVExtend trial showed benefits of abaloparatide followed by alendronate for maintained bone protection.
Typical Dose
80mcg per injection
Frequency
once daily
Cycle Duration
Up to 24 months lifetime cumulative use
Storage
Commercial pen (Tymlos): refrigerated at 2–8°C before first use; after first use, store at room temperature (20–25°C) for up to 30 days. Research powder: store at -20°C long-term; reconstituted solution at 2–8°C short-term.
Chemical Makeup
Key benefits
Reduces incidence of new vertebral fractures by approximately 86% compared to placebo in postmenopausal women with osteoporosis
Significantly reduces nonvertebral fracture risk, demonstrating superiority over placebo in the Phase III ACTIVE trial
Increases bone mineral density at the lumbar spine, total hip, and femoral neck more rapidly than teriparatide at 6, 12, and 18 months
Selectively activates the RG conformation of PTH1R for more transient cAMP signaling, resulting in lower risk of hypercalcemia compared to PTH(1-34)
Community interest
This peptide is still gaining traction in the community.
PTH1R Agonist | Osteoporosis & Bone Density
This overview is informational and based on aggregated descriptions from studies and user reports.
Was it helpful?YesNoAbaloparatide Molecular Information
View the scientifc details of Abaloparatide.
34
Amino Acids
Abaloparatide
Ala
Ala
Position 1
Val
Val
Position 2
Ser
Ser
Position 3
Glu
Glu
Position 4
His
His
Position 5
Gln
Gln
Position 6
Leu
Leu
Position 7
Leu
Leu
Position 8
His
His
Position 9
Asp
Asp
Position 10
Lys
Lys
Position 11
Gly
Gly
Position 12
Lys
Lys
Position 13
Ser
Ser
Position 14
Ile
Ile
Position 15
Gln
Gln
Position 16
Asp
Asp
Position 17
Leu
Leu
Position 18
Arg
Arg
Position 19
Arg
Arg
Position 20
Arg
Arg
Position 21
Glu
Glu
Position 22
Leu
Leu
Position 23
Leu
Leu
Position 24
Glu
Glu
Position 25
Lys
Lys
Position 26
Leu
Leu
Position 27
Leu
Leu
Position 28
?
?
Position 29
Lys
Lys
Position 30
Leu
Leu
Position 31
His
His
Position 32
Thr
Thr
Position 33
Ala
Ala
Position 34
Molecular Weight
3959.65DaChain Length
34Amino AcidsType
PeptideAbaloparatide Protocols
Abaloparatide is administered as a subcutaneous injection into the periumbilical region of the abdomen once daily. The medication comes as a pre-filled liquid solution pen (TYMLOS) requiring no reconstitution — it is ready to inject directly from the pen.
| Goal | Dosage | Frequency | Route |
|---|---|---|---|
| Reduce vertebral and nonvertebral fracture risk in postmenopausal women with osteoporosis, as demonstrated by 86% RRR for vertebral fractures in the ACTIVE trial. | 80 | 1 day range | SubQ periumbilical abdomen |
| Increase bone mineral density at the lumbar spine and hip in men with osteoporosis at high fracture risk. | 80 | 1 day range | SubQ periumbilical abdomen |
| Maximise bone formation during the permitted 2-year lifetime treatment window before transitioning to an antiresorptive agent to consolidate gains. | 80 | 1 day range | SubQ periumbilical abdomen |
| Build new bone with abaloparatide for up to 24 months then follow with alendronate to preserve and extend BMD gains, a strategy shown to outperform teriparatide-to-alendronate sequencing. | 80 | 1 day range | SubQ periumbilical abdomen |
| Restore bone formation in patients who continue to fracture or fail to gain BMD despite prior bisphosphonate therapy, leveraging abaloparatide's anabolic mechanism rather than antiresorptive action. | 80 | 1 day range | SubQ periumbilical abdomen |
Reconstitution Instructions
Materials needed:
Steps to reconstitute
- Wash and dry hands thoroughly before handling the pen.
- Remove the pen cap and visually inspect the cartridge — the solution should be clear, colorless, and free of particles; do not use if cloudy or discolored.
- Attach a new pen needle by removing the protective paper from the outer needle cap and screwing the needle straight onto the pen until fixed.
- Select an injection site in the lower abdomen (periumbilical region), staying at least 2 inches away from the belly button; rotate sites with each injection.
- Clean the selected injection site with an alcohol swab using a circular motion and allow the skin to air-dry completely before injecting.
- Pinch the skin at the selected site, insert the needle at a 90-degree angle, and press the green injection button fully until it will not go further.
- Hold the pen in place for a few seconds after pressing the button to ensure the full 80 mcg dose is delivered, then withdraw the needle.
- Carefully remove the needle from the pen after each use and dispose of it in a sharps container; replace the pen cap for storage.
- Before first use, store the pen refrigerated at 36–46°F (2–8°C); after first use, store at room temperature 68–77°F (20–25°C) for up to 30 days.
Abaloparatide Cycle
The Abaloparatide Cycle section explains how long a typical cycle lasts and what to expect during each phase. Over time, your body can become less responsive with continuous use.
Taking breaks between cycles may help maintain effectiveness and support better overall results.
- Month 1-3
- Bone formation markers increase; initial BMD changes begin
- Month 3-6
- Significant BMD increases at spine, hip, and femur
- Month 6-12
- Continued bone density improvements; fracture risk reduction
- Month 12-18
- Maximum benefits in ACTIVE trial; substantial fracture reduction
- Month 18-24
- Transition to maintenance therapy (e.g., bisphosphonates) recommended
Dosing tools
Abaloparatide Peptide Dosage Calculator
Calculate peptide doses with our visual syringe guide.
mg
Enter the total amount of peptide in the vial in milligrams (as stated on the label).
The dose you want to inject per administration, in mcg or mg.
1,000 mcg = 1 mg
1 mL
2 mL
3 mL
5 mL
Custom
Volume of bacteriostatic water you add to reconstitute the powder. Use BAC water for preservation.
Injection Results
Based on your vial and dilution inputs.
Abaloparatide
SINGLE COMPOUNDVolume per injection
0.05
mL
Concentration
10.00
mg/mL
Doses per vial
20
doses
Total injections per vial
20 injections
How it works
Based on a 10 mg Abaloparatide vial diluted with 1 mL of bacteriostatic water, each 500 mcg injection equals 0.05 mL.
1mL / 100 units
5 units
0.050 mL
Reference Guide
Dosing Cycle
- Peptide
- Abaloparatide
- Dosing
- 80mcg per injection
- Dosing Frequency
- once daily
- Cycle Duration
- Up to 24 months lifetime cumulative use
- Storage
- Commercial pen (Tymlos): refrigerated at 2–8°C before first use; after first use, store at room temperature (20–25°C) for up to 30 days. Research powder: store at -20°C long-term; reconstituted solution at 2–8°C short-term.
Note: Triple agonist; microdose for fewer side effects
Reconstitution Tips
- Use bacteriostatic water (BAC) — contains 0.9% benzyl alcohol for preservation
- Inject water slowly — aim down the vial wall, not directly onto powder
- Never shake — gently swirl or roll the vial until dissolved
- Store properly — refrigerate at 2-8°C after reconstitution
- Use within 28 days — most reconstituted peptides remain stable for about 4 weeks
- Keep sterile — always clean vial tops with alcohol before drawing
Peptide Interactions
Research suggestions of Abaloparatide interactions with other common peptides and substances.
Healing
ter
Teriparatide
AVOID
Do not use concurrently; both are PTH receptor agonists. Choose one or use sequentially.
Side effects
Avoid: Do not take Abaloparatide with Teriparatide.
Contraindications
Paget's disease of bone
Prior external beam or implant radiation therapy to skeleton
Bone metastases or history of skeletal malignancies
Metabolic bone diseases other than osteoporosis
Pre-existing hypercalcemia
Pregnancy or nursing
Cumulative use exceeding 2 years lifetime
Stop signs
Signs of hypercalcemia (confusion, fatigue, excessive thirst)
Persistent bone pain
Severe dizziness or fainting
Allergic reactions
Bad signs
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Frequently asked questions
What is a peptide dosage calculator?
A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringeunits to draw. This calculator works for single peptide compounds and multi-peptide blends.
How do I calculate peptide dosage from a vial?
To calculate your peptide dose, divide the total peptide content of your vial in micrograms by the volume of bacteriostatic water you added in milliliters. This gives you your solution concentration in mcg/mL. Then divide your target dose by that concentration to get your draw volume. For example, a 5mg (5,000 mcg) vial reconstituted with 2mL of BAC water gives a concentration of 2,500 mcg/mL. A 250 mcg dose would require drawing 0.1mL. This calculator automates all of those steps instantly.
How much Bacteriostatic water should I add to a peptide vial?
Most people add 2mL to 3mL of bacteriostatic water per vial, but the right amount depends on the dose you want to draw and the syringe size you are using. Adding 1mL to a 5mg vial gives you a concentration of 5,000 mcg/mL, making each dose very small in volume. Adding 2mL gives you 2,500 mcg/mL, which is easier to measure on a standard insulin syringe. A general guideline is to choose a volume that puts your typical dose somewhere between 10 and 30 units on a U-100 syringe. Use the calculator above to test different water volumes and find what works for your dose.
How are peptides different from proteins?
Both are made of amino acids, but peptides are much smaller than proteins. Because of their tiny size, peptides can act like tiny messengers in the body, sending specific signals to your cells to tell them exactly what to do.
AbaloparatideResearch References
Abaloparatide is a fda approved compound
Abaloparatide
Abaloparatide is a fda approved compound
Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis (ACTIVE Trial)
Abaloparatide showed substantial reduction in vertebral fractures and greater BMD increases at spine, hip, and femur compared to placebo and teriparatide.
n.d.
ACTIVExtend Trial: Abaloparatide Followed by Alendronate
18 months abaloparatide followed by alendronate significantly reduced vertebral and nonvertebral fractures.
n.d.
Phase 2 Dose-finding Study of BA058 in Postmenopausal Women
Significant BMD increases at 40 and 80 mcg doses; abaloparatide showed superior anabolic effects on hips vs teriparatide.
n.d.
Profile of Abaloparatide and Its Potential in Postmenopausal Osteoporosis
Abaloparatide preferentially binds RG conformational state of PTH1R, producing more anabolic bone effects.
n.d.
Calculate peptide dosages
Learning how to calculate a peptide dose? Use our beginner-friendly peptide dosage, blend, and accumulation calculators. Enter vial size, reconstitution volume, and target dose to get exact draw volumes instantly. No guesswork, just clear guidance that helps prevent common mistakes.
